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Distribution of EGFR Mutations in 10,607 Russian Patients with Lung Cancer

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Abstract

Introduction

This study was aimed to evaluate distribution of epidermal growth factor receptor (EGFR) mutations in a large series of Russian lung cancer (LC) patients.

Methods

10,607 LC samples were considered for EGFR analysis; EGFR status was successfully determined in 10,426 cases (98.3 %), indicating relatively low failure rate.

Results

EGFR mutations (ex19del and L858R) were detected in 1759/8716 (20.2 %) adenocarcinomas, 28/669 (4.2 %) squamous cell carcinomas (SCC) and 8/119 (6.7 %) large cell carcinomas. The occurrence of EGFR mutations in adenocarcinomas gradually increased with age, being attributed mainly to the increment of the L858R frequency in non-smokers (patients aged 18–30 years: 1/27 (3.7 %); 31–40 years: 5/98 (5.1 %); 41–50 years: 18/276 (6.5 %); 51–60 years: 102/944 (10.8 %); 61–70 years: 138/1011 (13.7 %); 71–80 years: 85/496 (17.1 %); 81–100 years: 5/27 (18.5 %); p < 0.0001). The EGFR mutation was detected in 804/2107 (38.2 %) non-smoking women versus 125/806 (15.5 %) non-smoking men (p < 0.0001), while the corresponding figures for smokers were 60/273 (22.0 %) versus 147/2214 (6.6 %) (p < 0.0001). The obtained gender-related data differ from the estimates obtained in Asian studies; they indicate that increased prevalence of EGFR mutations in white females may not be entirely attributed to the low prevalence of smoking, but is likely to be related to gender factors per se.

Conclusion

Biological causes of distinct age- and gender-related distribution of EGFR mutations in LC deserve further investigation.

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Author information

Authors and Affiliations

  1. N.N. Petrov Institute of Oncology, St.-Petersburg, 197758, Russia

    Evgeny N. Imyanitov, Aglaya G. Iyevleva, Natalia V. Mitiushkina, Ekatherina Sh. Kuligina & Svetlana N. Aleksakhina

  2. St.-Petersburg Pediatric Medical University, St.-Petersburg, 194100, Russia

    Evgeny N. Imyanitov & Aglaya G. Iyevleva

  3. I.I. Mechnikov North-Western Medical University, St.-Petersburg, 191015, Russia

    Evgeny N. Imyanitov

  4. St.-Petersburg State University, St.-Petersburg, 199034, Russia

    Evgeny N. Imyanitov & Svetlana N. Aleksakhina

  5. City Oncological Hospital No 62, Moscow, 143423, Russia

    Irina A. Demidova & Alexey A. Barinov

  6. Tatarstan Cancer Center, Kazan, 420029, Russia

    Marat G. Gordiev & Meriiam S. Mommaeva

  7. Institute of Chemical Biology and Fundamental Medicine, Novosibirsk, 630090, Russia

    Maxim L. Filipenko

  8. Research Center of Medical Genetics, Moscow, 115478, Russia

    Tatyana V. Kekeyeva

  9. Regional Oncological Hospital, Krasnodar, 350051, Russia

    Yuri K. Moliaka

  10. Tomsk Cancer Research Institute, Tomsk, 634028, Russia

    Polina A. Gervas

  11. Pacific Institute of Bioorganic Chemistry, Vladivostok, 690022, Russia

    Valeriy B. Kozhemyako

  12. Institute of Oncology, Rostov, 344037, Russia

    Dmitriy I. Vodolazhskiy

  13. Regional Oncological Hospital, Ekaterinburg, 620000, Russia

    Liubov A. Sergeyeva

  14. Oncological Hospital of the Republic of Bashkortostan, Ufa, 450054, Russia

    Dinara U. Fattakhova

  15. Russian Society of Clinical Oncology (RUSSCO), Moscow, 127051, Russia

    Ilya V. Tsimafeyeu

  16. N.N. Blokhin Cancer Center, Moscow, 115478, Russia

    Sergey A. Tjulandin

Authors
  1. Evgeny N. Imyanitov
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  2. Irina A. Demidova
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  3. Marat G. Gordiev
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  4. Maxim L. Filipenko
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  5. Tatyana V. Kekeyeva
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  6. Yuri K. Moliaka
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  7. Polina A. Gervas
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  8. Valeriy B. Kozhemyako
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  9. Dmitriy I. Vodolazhskiy
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  10. Liubov A. Sergeyeva
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  11. Dinara U. Fattakhova
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  12. Aglaya G. Iyevleva
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  13. Natalia V. Mitiushkina
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  14. Ekatherina Sh. Kuligina
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  15. Alexey A. Barinov
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  16. Meriiam S. Mommaeva
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  17. Svetlana N. Aleksakhina
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  18. Ilya V. Tsimafeyeu
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  19. Sergey A. Tjulandin
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Corresponding author

Correspondence to Evgeny N. Imyanitov.

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Conflict of interest

E. Imyanitov, I. Demidova, M. Gordiev, M. Filipenko, T. Kekeyeva, Y. Moliaka, P. Gervas, V. Kozhemyako, D. Vodolazhskiy, L. Sergeyeva, D. Fattakhova, A. Iyevleva, N. Mitiushkina, E. Kuligina, A. Barinov, M. Mommaeva, S. Aleksakhina, I. Tsimafeyeu and S. Tjulandin declare that they have no competing interests.

Funding

This study has been supported by the Russian Society of Clinical Oncology (RUSSCO). A. Iyevleva, N. Mitiushkina and S. Aleksakhina are supported by the Russian Federation for Basic Research (Grants 14-04-00460, 16-04-00154 and 14-04-01869, respectively).

Ethical approval and informed consent

All patients participating in the study provided written informed consent. The study was approved by the RUSSCO Ethical committee (approval number 12/3).

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Imyanitov, E.N., Demidova, I.A., Gordiev, M.G. et al. Distribution of EGFR Mutations in 10,607 Russian Patients with Lung Cancer. Mol Diagn Ther 20, 401–406 (2016). https://doi.org/10.1007/s40291-016-0213-4

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  • DOI: https://doi.org/10.1007/s40291-016-0213-4

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