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The Response of Matrix Metalloproteinase-9 and -2 to Exercise

  • Systematic Review
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Abstract

Background

Matrix metalloproteinases (MMPs) are a major group of enzymes that play essential roles in normal functioning of diverse tissues during growth, development, and aging. However, among the MMPs little is known regarding the role of exercise in MMP-9 and MMP-2 function in humans.

Objective

The aim of this study was to provide a systematic comprehensive review of the literature examining the effect of different exercise interventions on MMP-9 and MMP-2 in human investigations.

Data Sources

A comprehensive systematic database search was performed, including PubMed/MEDLINE, Scopus, ScienceDirect, and Web of Science.

Study Selection

Both the acute and chronic effects of exercise were included for evaluation in this systematic review. Inclusion criteria included the use of any type of planned, structured, and repetitive movement and its effects on the MMP-2 and MMP-9 response (obtained from plasma samples), participants (humans only) of any age with or without diseases, sedentary participants and those involved in light, moderate, and vigorous activity, randomized controlled trials (RCTs) and clinical trials (CTs), full text article citations with no restrictions in terms of language, and scored at least 5/11 on the Physiotherapy Evidence Database (PEDro) quality scale.

Study Appraisal and Synthesis Methods

The PEDro scale was used to appraise study quality of RCTs and CTs. Two reviewers independently reviewed the full texts of all potentially relevant articles for eligibility and disagreements were discussed and resolved.

Results

Seven studies met the previously determined quality indicators and were reviewed; three were RCTs and four were CTs. In general, the quality of the studies ranged from 5 to 9 out of a maximum of 11 on the PEDro quality criteria scale. Results revealed that chronic aerobic training induces a decrease in MMP-9 and MMP-2 levels, possibly indicating a cardioprotective effect, while resistance exercise training displayed conflicting results.

Conclusion

Alterations in MMP-9 and MMP-2 plasma concentrations may be valuable biomarkers to reflect the influence of exercise on the inflammatory state. Nevertheless, the limited evidence available regarding the effects of exercise on the MMP-9 and MMP-2 response in human participants suggests that further studies are needed to fully define the connection between the role of exercise on the MMP-9 and MMP-2 response.

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References

  1. Carmeli E, Moas M, Reznick AZ, et al. Matrix metalloproteinases and skeletal muscle: a brief review. Muscle Nerve. 2004;29(2):191–7.

    Article  CAS  PubMed  Google Scholar 

  2. Parks WC, Mecham RP. Extracellular matrix degradation. New York: Springer; 2011.

    Book  Google Scholar 

  3. Madden MC, Byrnes WC, Lebin JA, et al. Plasma matrix metalloproteinase-9 response to eccentric exercise of the elbow flexors. Eur J Appl Physiol. 2011;111(8):1795–805.

    Article  CAS  PubMed  Google Scholar 

  4. Hopps E, Caimi G. Matrix metalloproteinases in metabolic syndrome. Eur J Intern Med. 2012;23(2):99–104.

    Article  CAS  PubMed  Google Scholar 

  5. Lindsey M, Wedin K, Brown MD, et al. Matrix-dependent mechanism of neutrophil-mediated release and activation of matrix metalloproteinase 9 in myocardial ischemia/reperfusion. Circulation. 2001;103(17):2181–7.

    Article  CAS  PubMed  Google Scholar 

  6. Dominguez-Rodriguez A, Abreu-Gonzalez P, Garcia-Gonzalez MJ, et al. High serum matrix metalloproteinase-9 level predict increased risk of in-hospital cardiac events in patients with type 2 diabetes and ST segment elevation myocardial infarction. Atherosclerosis. 2008;196(1):365–71.

    Article  CAS  PubMed  Google Scholar 

  7. Hsu TW, Kuo KL, Hung SC, et al. Progression of kidney disease in non-diabetic patients with coronary artery disease: predictive role of circulating matrix metalloproteinase-2, -3, and -9. PLoS One. 2013;8(7):e70132.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  8. Urso ML, Pierce JR, Alemany JA, et al. Effects of exercise training on the matrix metalloprotease response to acute exercise. Eur J Appl Physiol. 2009;106(5):655–63.

    Article  CAS  PubMed  Google Scholar 

  9. Lucotti P, Monti LD, Setola E, et al. Aerobic and resistance training effects compared to aerobic training alone in obese type 2 diabetic patients on diet treatment. Diabetes Res Clin Pract. 2011;94(3):395–403.

    Article  PubMed  Google Scholar 

  10. Büyükyazı G, Ulman C, Taneli F, et al. The effects of an 8-week walking program on serum lipids, circulation matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 in post-menopausal women. Turk J Biochem. 2008;33(4):154–72.

    Google Scholar 

  11. Niessner A, Richter B, Penka M, et al. Endurance training reduces circulating inflammatory markers in persons at risk of coronary events: impact on plaque stabilization? Atherosclerosis. 2006;186(1):160–5.

    Article  CAS  PubMed  Google Scholar 

  12. Kadoglou NP, Vrabas IS, Sailer N, et al. Exercise ameliorates serum MMP-9 and TIMP-2 levels in patients with type 2 diabetes. Diabetes Metab. 2010;36(2):144–51.

    Article  CAS  PubMed  Google Scholar 

  13. Fiotti N, Deiuri E, Altamura N, et al. Body composition and muscular strength changes after moderate activity: association with matrix metalloproteinase polymorphisms. Arch Gerontol Geriatr. 2009;49(Suppl 1):83–94.

    Article  CAS  PubMed  Google Scholar 

  14. Koskinen SO, Heinemeier KM, Olesen JL, et al. Physical exercise can influence local levels of matrix metalloproteinases and their inhibitors in tendon-related connective tissue. J Appl Physiol (1985). 2004;96:861–4.

    Article  CAS  Google Scholar 

  15. Saenz AJ, Lee-Lewandrowski E, Wood MJ, et al. Measurement of a plasma stroke biomarker panel and cardiac troponin T in marathon runners before and after the 2005 Boston marathon. Am J Clin Pathol. 2006;126(2):185–9.

    Article  CAS  PubMed  Google Scholar 

  16. Liberati A, Altman DG, Tetzlaff J, et al. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. J Clin Epidemiol. 2009;62(10):e1–34.

    Article  PubMed  Google Scholar 

  17. Sampson M, McGowan J, Cogo E, et al. An evidence-based practice guideline for the peer review of electronic search strategies. J Clin Epidemiol. 2009;62(9):944–52.

    Article  PubMed  Google Scholar 

  18. Major MP, Major PW, Flores-Mir C. An evaluation of search and selection methods used in dental systematic reviews published in English. J Am Dent Assoc. 2006;137(9):1252–7.

    Article  PubMed  Google Scholar 

  19. Moseley AM, Herbert RD, Sherrington C, et al. Evidence for physiotherapy practice: a survey of the Physiotherapy Evidence Database (PEDro). Aust J Physiother. 2002;48(1):43–9.

    Article  PubMed  Google Scholar 

  20. Maher CG, Sherrington C, Herbert RD, et al. Reliability of the PEDro scale for rating quality of randomized controlled trials. Phys Ther. 2003;83(8):713–21.

    PubMed  Google Scholar 

  21. Maher CG. A systematic review of workplace interventions to prevent low back pain. Aust J Physiother. 2000;46(4):259–69.

    Article  PubMed  Google Scholar 

  22. International Clinical Trials Registry Platform (ICTRP). Geneva: WHO. http://www.who.int/ictrp/about/details/en/index.html. Accessed 16 July 2014.

  23. Bonnema DD, Webb CS, Pennington WR, et al. Effects of age on plasma matrix metalloproteinases (MMPs) and tissue inhibitor of metalloproteinases (TIMPs). J Card Fail. 2007;13(7):530–40.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  24. Koskinen SO, Hoyhtya M, Turpeenniemi-Hujanen T, et al. Serum concentrations of collagen degrading enzymes and their inhibitors after downhill running. Scand J Med Sci Sports. 2001;11(1):9–15.

    Article  CAS  PubMed  Google Scholar 

  25. Steenport M, Khan KM, Du B, et al. Matrix metalloproteinase (MMP)-1 and MMP-3 induce macrophage MMP-9: evidence for the role of TNF-alpha and cyclooxygenase-2. J Immunol. 2009;183(12):8119–27.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  26. Kwak HB. Aging, exercise, and extracellular matrix in the heart. J Exerc Rehabil. 2013;9(3):338–47.

    Article  PubMed Central  PubMed  Google Scholar 

  27. Gleeson M, Bishop NC, Stensel DJ, et al. The anti-inflammatory effects of exercise: mechanisms and implications for the prevention and treatment of disease. Nat Rev Immunol. 2011;11(9):607–15.

    Article  CAS  PubMed  Google Scholar 

  28. Buford TW, Roberts MD, Church TS. Toward exercise as personalized medicine. Sports Med. 2013;43(3):157–65.

    Article  PubMed Central  PubMed  Google Scholar 

  29. Rullman E, Olsson K, Wagsater D, et al. Circulating MMP-9 during exercise in humans. Eur J Appl Physiol. 2013;113(5):1249–55.

    Article  CAS  PubMed  Google Scholar 

  30. Hoier B, Nordsborg N, Andersen S, et al. Pro- and anti-angiogenic factors in human skeletal muscle in response to acute exercise and training. J Physiol. 2012;590(Pt 3):595–606.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  31. Dennis RA, Zhu H, Kortebein PM, et al. Muscle expression of genes associated with inflammation, growth, and remodeling is strongly correlated in older adults with resistance training outcomes. Physiol Genomics. 2009;38(2):169–75.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  32. Rullman E, Norrbom J, Stromberg A, et al. Endurance exercise activates matrix metalloproteinases in human skeletal muscle. J Appl Physiol (1985). 2009;106(3):804–12.

    Article  CAS  Google Scholar 

  33. Hellsten Y, Rufener N, Nielsen JJ, et al. Passive leg movement enhances interstitial VEGF protein, endothelial cell proliferation, and eNOS mRNA content in human skeletal muscle. Am J Physiol Regul Integr Comp Physiol. 2008;294(3):R975–82.

    Article  CAS  PubMed  Google Scholar 

  34. Dennis RA, Przybyla B, Gurley C, et al. Aging alters gene expression of growth and remodeling factors in human skeletal muscle both at rest and in response to acute resistance exercise. Physiol Genomics. 2008;32(3):393–400.

    Article  CAS  PubMed  Google Scholar 

  35. Rullman E, Rundqvist H, Wagsater D, et al. A single bout of exercise activates matrix metalloproteinase in human skeletal muscle. J Appl Physiol. 2007;102(6):2346–51.

    Article  CAS  PubMed  Google Scholar 

  36. Mackey AL, Donnelly AE, Turpeenniemi-Hujanen T, et al. Skeletal muscle collagen content in humans after high-force eccentric contractions. J Appl Physiol. 2004;97(1):197–203.

    Article  CAS  PubMed  Google Scholar 

  37. Reihmane D, Jurka A, Tretjakovs P, et al. Increase in IL-6, TNF-alpha, and MMP-9, but not sICAM-1, concentrations depends on exercise duration. Eur J Appl Physiol. 2013;113(4):851–8.

    Article  CAS  PubMed  Google Scholar 

  38. Nourshahi M, Hedayati M, Ranjbar K. The correlation between resting serum leptin and serum angiogenic indices at rest and after submaximal exercise. Regul Pept. 2012;173(1–3):6–12.

    Article  CAS  PubMed  Google Scholar 

  39. Mackey AL, Donnelly AE, Roper HP. Muscle connective tissue content of endurance-trained and inactive individuals. Scand J Med Sci Sports. 2005;15(6):402–8.

    Article  CAS  PubMed  Google Scholar 

  40. Sullivan BE, Carroll CC, Jemiolo B, et al. Effect of acute resistance exercise and sex on human patellar tendon structural and regulatory mRNA expression. J Appl Physiol. 2009;106(2):468–75.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  41. Gatta L, Armani A, Iellamo F, et al. Effects of a short-term exercise training on serum factors involved in ventricular remodelling in chronic heart failure patients. Int J Cardiol. 2012;155(3):409–13.

    Article  PubMed  Google Scholar 

  42. Shon SM, Park JH, Nahrendorf M, et al. Exercise attenuates matrix metalloproteinase activity in preexisting atherosclerotic plaque. Atherosclerosis. 2011;216(1):67–73.

    Article  CAS  PubMed  Google Scholar 

  43. Hailes WS, Slivka D, Cuddy J, et al. Human plasma inflammatory response during 5 days of exercise training in the heat. J Therm Biol. 2011;36(5):277–82.

    Article  Google Scholar 

  44. Suhr F, Rosenwick C, Vassiliadis A, et al. Regulation of extracellular matrix compounds involved in angiogenic processes in short- and long-track elite runners. Scand J Med Sci Sports. 2010;20(3):441–8.

    Article  CAS  PubMed  Google Scholar 

  45. Hu FB, Sigal RJ, Rich-Edwards JW, et al. Walking compared with vigorous physical activity and risk of type 2 diabetes in women: a prospective study. JAMA. 1999;282(15):1433–9.

    Article  CAS  PubMed  Google Scholar 

  46. Roberts CK, Won D, Pruthi S, et al. Effect of a short-term diet and exercise intervention on oxidative stress, inflammation, MMP-9, and monocyte chemotactic activity in men with metabolic syndrome factors. J Appl Physiol. 2006;100(5):1657–65.

    Article  CAS  PubMed  Google Scholar 

  47. Roberts CK, Chen AK, Barnard RJ. Effect of a short-term diet and exercise intervention in youth on atherosclerotic risk factors. Atherosclerosis. 2007;191(1):98–106.

    Article  CAS  PubMed  Google Scholar 

  48. Mackey AL, Donnelly AE, Swanton A, et al. The effects of impact and non-impact exercise on circulating markers of collagen remodelling in humans. J Sports Sci. 2006;24(8):843–8.

    Article  PubMed  Google Scholar 

  49. Hoier B, Rufener N, Bojsen-Moller J, et al. The effect of passive movement training on angiogenic factors and capillary growth in human skeletal muscle. J Physiol. 2010;588(Pt 19):3833–45.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  50. Danzig V, Mikova B, Kuchynka P, et al. Levels of circulating biomarkers at rest and after exercise in coronary artery disease patients. Physiol Res. 2010;59(3):385–92.

    CAS  PubMed  Google Scholar 

  51. Suhr F, Brixius K, de Marees M, et al. Effects of short-term vibration and hypoxia during high-intensity cycling exercise on circulating levels of angiogenic regulators in humans. J Appl Physiol. 2007;103(2):474–83.

    Article  CAS  PubMed  Google Scholar 

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Acknowledgments

No sources of funding were used to assist in the preparation of this review. The authors have no conflicts of interest that are directly relevant to the content of this review. The first author would like to thank his family, and in particular his mother Rita Cunha and his son Nicolas Cunha.

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Authors and Affiliations

  1. Graduation Program on Physical Education, Catholic University of Brasilia, Q.S. 07, Lote 01, EPTC-Bloco G, Brasilia, DF, 71966-700, Brazil

    Dahan da Cunha Nascimento, Ramires Alsamir Tibana & Jonato Prestes

  2. Physical Therapy, University of Brasilia, Ceilandia, Brazil

    Rita de Cassia Marqueti Durigan & João Luiz Quagliotti Durigan

  3. Department of Kinesiology and Nutrition Sciences of the University of Nevada, Las Vegas, NV, USA

    James Wilfred Navalta

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  1. Dahan da Cunha Nascimento
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  2. Rita de Cassia Marqueti Durigan
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  3. Ramires Alsamir Tibana
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  6. Jonato Prestes
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Correspondence to Dahan da Cunha Nascimento.

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da Cunha Nascimento, D., de Cassia Marqueti Durigan, R., Tibana, R.A. et al. The Response of Matrix Metalloproteinase-9 and -2 to Exercise. Sports Med 45, 269–278 (2015). https://doi.org/10.1007/s40279-014-0265-8

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