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Brodalumab: First Global Approval

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An Erratum to this article was published on 22 September 2016

Abstract

Brodalumab (Lumicef®) is a human monoclonal immunoglobulin G antibody that is being developed by Kyowa Hakko Kirin in Japan, where it has been approved for the treatment of psoriasis vulgaris, psoriatic arthritis, pustular psoriasis and psoriatic erythroderma. Brodalumab binds with high affinity to interleukin (IL)-17 receptor A, thereby inhibiting several pro-inflammatory cytokines from the IL-17 family. Regulatory applications for brodalumab in plaque psoriasis are also under review in the USA, EU and Canada. This article summarizes the milestones in the development of brodalumab leading to this first approval for the treatment of psoriasis.

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  1. Springer, Private Bag 65901, Mairangi Bay, Auckland, 0754, New Zealand

    Sarah L. Greig

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  1. Sarah L. Greig
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Correspondence to Sarah L. Greig.

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Disclosure

The preparation of this review was not supported by any external funding. During the peer review process the manufacturer of the agent under review was offered an opportunity to comment on the article. Changes resulting from any comments received were made by the author on the basis of scientific completeness and accuracy. Sarah Greig is a salaried employee of Adis, Springer SBM.

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This profile has been extracted and modified from the AdisInsight database. AdisInsight tracks drug development worldwide through the entire development process, from discovery, through pre-clinical and clinical studies to market launch and beyond.

An erratum to this article can be found at http://dx.doi.org/10.1007/s40265-016-0647-3.

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Greig, S.L. Brodalumab: First Global Approval. Drugs 76, 1403–1412 (2016). https://doi.org/10.1007/s40265-016-0634-8

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