Dear Reader,

As we approach the end of 2015, and publish our final issue of Drugs for the year, the editors and production staff at Adis wish to reflect on another successful year’s achievements and pay thanks to all those who have contributed their time and effort to guarantee the exceptional quality of our content.

We are delighted to have seen the conclusion of formalities surrounding the joint venture of Springer Science+Business Media with Nature Publishing Group, Palgrave Macmillan, Macmillan Education in early May. Substantial ground has already been made in the integration of business within the resulting Springer Nature company and we at Adis look eagerly toward the future, as the benefits of the collective expertise and capabilities of this company carry us forward.

The majority of our journals saw a rise in ISI impact factor against the previous year, including Drugs. Most notably, BioDrugs increased by 41 % to 2.989; the European Journal of Drug Metabolism and Pharmacokinetics increased 19 % to 1.563; CNS Drugs increased by 17 % to 5.113; Targeted Oncology increased 16 % to 4.000; Pediatric Drugs increased 15 % to 1.975; Drugs & Aging increased 13 % to 2.838; and Molecular Diagnosis & Therapy increased a further 12 % to 2.891, having already jumped 53 % in the preceding year. We hope to build upon these gains, once more, in 2016.

We offer our sincere thanks to all authors who have contributed articles to Drugs over the course of 2015. Their skill and dedication are critical to the continued publication of the journal. The world-class quality of published articles is, similarly, testament to the significant efforts of the peer reviewers, whose commitment ensures that our content is held to the highest possible standard. We would like to take this opportunity to sincerely thank retiring Honorary Editorial Board members Professors Gabriele Bianchi Porro, Frederick Fraunfelder, Malcolm Lader OBE, Charles Nightingale and Allister Vale, and to welcome new members Professors Susan R. Davis and Andreas H. Groll and thank them for their willingness to contribute to the success of Drugs. In addition to the members of our highly respected and valued Honorary Editorial Board, we would like to thank the following individuals who acted as reviewers for articles published in Drugs in 2015:

Muhammad Abdul-Ghani, USA

Maurizio G. Abrignani, Italy

Edward Acosta, USA

Joachim G. Aerts, The Netherlands

Tove Agner, Denmark

Carlos A. Aguilar-Salinas, Mexico

Timothy Albertson, USA

S. Alfandari, France

Yasser M. Amr, Egypt

Gattadahalli M. Anantharamaiah, USA

Emmanuel Andres, France

Paul L. Andrews, UK

Javier Cuesta Angulo, Spain

Sabina A. Antoniu, Romania

Andrea Antonuzzo, Italy

A. Apostolidis, Greece

Giuseppe Aprile, Italy

Alireza Atri, USA

A. Awada, Belgium

Farrukh Awan, USA

Hatem A. Azim, Belgium

Emmanuel Bachy, France

Emilio Badoer, Australia

Natasha Bagdasarian, USA

Robert A. Baiocchi, USA

Yung-Jue Bang, Republic of Korea

Robert L. Barkin, USA

F. C. Barreto, Brazil

David S. H. Bell, USA

Marc A. Benninga, The Netherlands

James R. Berenson, USA

Gregory K. Bergey, USA

Gaetano Bertino, Italy

Qi Bi, China

Maria Luisa Bianchi, Italy

Andreas Binder, Germany

T. Bisgaard, Denmark

Corrado Blandizzi, Italy

Francesco Blasi, Italy

Stijn I. Blot, Belgium

Jill Blumenthal, USA

Helen W. Boucher, USA

P. F. Boudes, USA

Thierry Boulain, France

David Boyer, USA

Robert A. Bray, USA

Harald Breivik, Norway

David C. Broadway, UK

Etienne Brochot, France

Christina Brock, Denmark

Martin J. Brodie, UK

Adam M. Brufsky, USA

Patrik Brundin, USA

Klemens Budde, Germany

Hildegard Buening, Germany

P. Sherwood Burge, UK

Maria Buti, Spain

Angelo Cagnacci, Italy

Tommaso Cai, Italy

Peter A. Calabresi, USA

R. Keith Campbell, USA

Richard Carlson, USA

Teresa L. Carman, USA

John T. Carpenter, USA

Kirstin Carswell, UK

Elena Cassinerio, Italy

Christian R. Cavé, France

Luigi Celio, Italy

Laura Cerchia, Italy

Asim N. Cheema, Canada

Laurent Chiche, France

Christos Chouaïd, France

Laura Q. M. Chow, USA

Pratima Chowdary, UK

Philip Clements, USA

Nathan Clumeck, Belgium

David R. Coghill, UK

Mark S. Cohen, USA

Kirsten Colpaert, Belgium

Michael Colucciello, USA

Samuele Cortese, UK

Patrice Courvalin, France

Lucio Crinò, Italy

Antonio Cuneo, Italy

Ronald Dahl, Denmark

Ann K. Daly, UK

Paresh Dandona, USA

S. Lindsey Davis, USA

Mellar Davis, USA

David Dawe, Canada

W. W. de Herder, The Netherlands

Alejandro de la Sierra, Spain

Sven de Vos, USA

Julio Delgado, Spain

Eric Derom, Belgium

Giuseppe Derosa, Italy

Daan Dierickx, Belgium

George Dimitriadis, Greece

Paola Divieti-Pajevic, USA

Yohei Doi, USA

P. Dorozynski, Poland

Jonathan Douxfils, Belgium

Martin Dreyling, Germany

George L. Drusano, USA

Eric Druyts, Canada

Rafael F. Duarte, Spain

Paul L. Durham, USA

Anthony D. D’Urzo, Canada

Janice P. Dutcher, USA

Martin J. S. Dyer, UK

Mervyn J. Eadie, Australia

M. R. Ehlers, USA

Mattias Ekstedt, Sweden

Laurie Elit, Canada

Johan G. Eriksson, Finland

L. R. Espinoza, USA

A. Fassoulaki, Greece

Nicola Fazio, Italy

Steven Feldman, USA

Peter Ferenci, Austria

J. M. Fernández-Gómez, Spain

Dominic Fitzgerald, Australia

John M. Flack, USA

Christina J. Flaxel, USA

Harris E. Foster Jr, USA

Mark S. Freedman, Canada

Masahiro M. Fukuoka, Japan

Huldrych F. Günthard, Switzerland

Monica Gadelha, Brazil

Justin F. Gainor, USA

Aristea S. Galanopoulou, USA

Joel E. Gallant, USA

L. Gandhi, USA

V. G. R. Gangireddy, USA

Lie Gao, USA

Pilar Garcia, Spain

Christopher R. Garrett, USA

Serge Gauthier, Canada

Arthur F. Gelb, USA

Christopher Gilmore, USA

J. González-Barboteo, Spain

Ajay K. Gopal, USA

David A. Gorelick, USA

Luis Graca, Portugal

Ludovica Grasso, Switzerland

J. Greiner, USA

John G. Gums, USA

Felix Gutierrez, Spain

Ashraf Samir Habib, USA

Zohar Habot-Wilner, Israel

Lars Hagmeyer, Germany

Uli Hahn, Germany

George Han, USA

Guy Hans, Belgium

Shuko Harada, USA

Karen L. Hardinger, USA

Ozgurmd Harmanci, Turkey

Robert A. Hegele, Canada

Wayne J. G. Hellstrom, USA

K. Henriksen, Denmark

Patries M. Herst, New Zealand

Vera Hirsh, Canada

Laurent Hocqueloux, France

Herbert Hof, Germany

Christine Hofmann, Germany

Nicholas H. G. Holford, New Zealand

Gábor Holló, Hungary

Natasha Holmes, Australia

Michael Horberg, USA

Nobuyuki Horita, Japan

Philippe Huot, Canada

Tahir Hussain, USA

Murat Inanc, Turkey

Cristoforo Incorvaia, Italy

Lars Ittner, Australia

Markus Jager, Germany

Amteshwar Jaggi, India

Rakesh Jain, USA

Marko Jakopovic, Croatia

Ahmad Jalili, Austria

T. L. Jansen, The Netherlands

Kurt Jellinger, Austria

Gregor B. Jemec, Denmark

Derek D. P. Jewell, UK

Andrew S. Jeyaruban, Australia

Mats Johnson, Sweden

Gordon Johnston, USA

Ronald N. Jones, USA

Evan C. Jones, USA

H. G. Joost, Germany

Vladimir Jurisic, Serbia

Kohei Kaku, Japan

Yuko Kaneko, Japan

Amrinder J. Kanwar, India

E. Kapiteijn, The Netherlands

C. Karapetis, Australia

Stylianos Karatapanis, Greece

Morten A. Karsdal, Denmark

Vikram Kate, India

Andreas Katsanos, Greece

Michael D. Kaufman, USA

Andrew M. Kaunitz, USA

Michael P. Keane, Ireland

Michael J. Keating, USA

Richard F. Kefford, Australia

Edward M. Kerwin, USA

Markus Ketteler, Germany

Puja Khanna, USA

Karl Kieburtz, USA

T. I. Kim, Republic of Korea

Richard Kim, USA

Dong-Wan Kim, Republic of Korea

June-Hong Kim, Republic of Korea

Allen B. King, USA

David G. I. Kingston, USA

Harriet M. Kluger, USA

Dieter Koeberle, Switzerland

Evert L. Koldewijn, The Netherlands

Adriaan Kooy, The Netherlands

Anthony L. Kovac, USA

Gregory Krauss, USA

Ernst J. Kuipers, The Netherlands

H. Kuo, Taiwan, Republic of China

John S. Kuo, USA

Wolfgang Löscher, Germany

Raymond W. Lam, Canada

Lorenza Landi, Italy

Stephen H. Landy, USA

Majella Lane, UK

Alexandra J. Lansky, USA

Mar Larrosa, Spain

Sergio Leonardi, Italy

Rupert Leong, Australia

Sharon Lewin, Australia

Jing Li, USA

Brian J. Linder, USA

Sultan Linjawi, Australia

M. Lishner, Israel

Linda Liu, USA

Eldon Loh, Canada

Ben M. Lomaestro, USA

Anthony Lopez, France

Jose Luis Lopez-Sendon, Spain

Jason J. Luke, USA

Elena Lukina, Russian Federation

M. P. Lutz, Germany

Giovanni Maconi, Italy

Franco Maggiolo, France

Bernhard Maisch, Germany

Marcio C. Mancini, Brazil

Alessandra Mangia, Italy

David M. Mannino, USA

Pier M. Mannucci, Italy

Oto Martinez Masa, USA

Céu Mateus, UK

Koji Matsuo, USA

Norma N. Maugeri, Italy

Julien Mazières, France

Denis M. McCarthy, USA

William McCloskey, USA

Susanna A. McColley, USA

Sheena McCormack, UK

David F. McDermott, USA

Atul A. B. Mehta, UK

Sebastiano Mercadante, Italy

Ruben A. Mesa, USA

Urs A. Meyer, Switzerland

Jörg Mezger, Germany

Manuele Michelessi, Italy

Juan A. Mico, Spain

Luis Miguel, Portugal

Emili E. Montserrat, Spain

John P. Mordes, USA

Bart Morlion, Belgium

Thomas Muller, Germany

Stephen Mulligan, Australia

Manuel Muro, Spain

Andrea Murru, Spain

Sylvie Négrier, France

Sharon A. Nachman, USA

Ramez Nairooz, USA

Jadwiga Najib, USA

Eliano Pio Navarese, Italy

Rudolph M. Navari, USA

Scott D. Nei, USA

G. T. Nepom, USA

Markus F. Neurath, Germany

Lindsay E. Nicolle, Canada

Milka W. Njoroge, USA

Dag Nyholm, Sweden

Donal O’Donoghue, UK

Carrie Oliphant, USA

Ignazio I. Olivieri, Italy

Matthew J. Olnes, USA

Saida Ortolano, Spain

Andrew Ostor, UK

Clive P. Page, UK

Anna Maria Paoletti, Italy

Vasilios Papademetriou, USA

Athanasios G. Papavassiliou, Greece

Marina Papoutsaki, Greece

John Pasi, UK

A. W. Pastuszak, USA

Jose Perez-Castrillon, Spain

Vasilios Pergialiotis, Greece

Joseph V. Pergolizzi, USA

Mauro Pettorruso, Italy

Adam Pluzanski, Poland

Charles V. Pollack Jr, USA

Garyphallia Poulakou, Greece

J. S. Powell, USA

Paolo Prandoni, Italy

Timothy Price, Australia

Massimo Puoti, Italy

Richard Quek, Singapore

Eamonn M. Quigley, USA

Daniel J. Quinlan, UK

Oliver Radke, Germany

Saifee Rashiq, Canada

Itamar Raz, Israel

Nishitha Reddy, USA

Noemi Reguart, Spain

Zeljko Reiner, Croatia

Lori Reisner, USA

Marc Rendell, USA

A. G Richetta, Italy

Leo V. Riella, USA

Anja Rinke, Germany

Olivier Rixe, USA

Tina Rizack, USA

Tadeusz Robak, Poland

David Robinson, Sweden

Keith A. Rodvold, USA

Claus G. Roehrborn, USA

James L. Roerig, USA

Christian Rolfo, Belgium

Manuel Romero-Gómez, Spain

Felix Rosenow, Germany

Andrea Rossi, Italy

David T. Rubin, USA

Matthew V. Rudorfer, USA

Piotr Rutkowski, Poland

Thomas Ruzicka, Germany

Donna H. Ryan, USA

Emilio Sacco, USA

Mohamed E. Salem, USA

Nathan Sandbo, USA

Uriel Sandkovsky, USA

Raul D. Santos, Brazil

Paul Sator, Austria

Michael P. Savage, USA

Michael R. Savona, USA

Gregory S. Sawicki, USA

R. G. Sawyer, USA

Jana J. Sawynok, Canada

Carmelo Scarpignato, Italy

André J. Scheen, Belgium

Philip Scheinberg, USA

Guntram Schernthaner, Austria

Manuela Schmidinger, Austria

Dieter Schmidt, Germany

Hans-Joachim Schmoll, Germany

David J. Schneider, USA

Karen Schreiber, UK

Nicola Scichilone, Italy

Beatrice M. Seddon, UK

Yutaka Seino, Japan

Rima B. Shah, India

Sandhu Shahneen, Australia

Amit Sharma, USA

Neil Shear, Canada

Yahya Shehabi, Australia

Alpana P. Shukla, USA

Tanja Sikjaer, Denmark

Robert Silbergleit, USA

Oguz Resat Sipahi, Turkey

Brandon G. Smaglo, USA

Joseph S. Solomkin, USA

Maria Souli, Greece

Stavros Spiliopoulos, Greece

Ramprasad Sripada, USA

Christopher Richar, Steer, UK

Michael Stewart, USA

Simone I. Strasser, Australia

Julia Marsh Sung, USA

Jacek C. Szepietowski, Poland

Hidetoshi Takedatsu, Japan

C. Tam, Australia

Frederik B. Thomsen, Denmark

Jerome E. Thurman, USA

Burkhard Toenshoff, Germany

Brian Tomlinson, Hong Kong

Roser Torra, Spain

Antoni Torres, Spain

Ian Tsang, Canada

Paul M. Tulkens, Belgium

Themistoklis Tzotzas, Greece

Muthiah Vaduganathan, USA

Willy M. Valencia, USA

Françoise Van Bambeke, Belgium

R. B. Vender, Canada

Srdan Verstovsek, USA

Andreas Viardot, Germany

Jean-Louis Vincent, Belgium

Francesco Viola, Italy

Massimo Volpe, Italy

Garry M. Walsh, UK

Justin Waters, UK

Bianca Weinstock-Guttman, USA

Robert Weiss, USA

B. B Weksler, USA

Eric Wenzler, USA

Victoria P. Werth, USA

Amber L. Wheeler, USA

Harry T. Whelan, USA

Andreas Wicki, Switzerland

Anthony S. Wierzbicki, UK

Fiona Wightman, Australia

Cynthia Willey, USA

Roger L. Williams, USA

James S. Wolffsohn, UK

Vincent C. Woo, Canada

Antoinette A. Wozniak, USA

M. Xing, USA

Kazuhiko Yamada, Japan

Takayuki Yamamoto, Japan

A. Yoshimura, Japan

Markus Zeitlinger, Austria

George G. Zhanel, Canada

Cheng-Jian Zheng, China

Focke Ziemssen, Germany

Pier L. Zinzani, Italy

We hope that you have found the articles published throughout 2015 to be both interesting and informative. The editors have appreciated the high quality of content contributed to the journal this year and look forward to keeping you up to date with topical issues in drug treatment in 2016.

With best wishes from the staff of Drugs and all at Adis Publications.