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Synthesis and pharmacodynamics of ibuprofen-1-acetoxyethyl ester

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Chemical Research in Chinese Universities Aims and scope

Abstract

Ibuprofen(IBU) and its derivatives are widely used in treating many diseases, such as depression, glomerulonephritis, fever caused by common cold or influenza, and rheumatoid arthritis. While in clinical trials, IBU was found to have many side effects. To weaken and prevent these side effects, a derivative called ibuprofen-1-acetoxyethyl ester was synthesized in this paper. The maximum concentration(c max) in a shorter time was compared with IBU at the same dose.

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References

  1. Zhao Y. M., Xia D., Ai C. P., Xiang G. Y., Chin. J. Med. Chem., 2005, 15(6), 360

    CAS  Google Scholar 

  2. Zhu J., Huang F., Chin. J. New Drugs, 2009, 18(6), 497

    CAS  Google Scholar 

  3. Zheng T. C., Fine Chem. Inter., 2010, 40(3), 1

    Google Scholar 

  4. Chen S. Y., Hang Q., Ao G. Z., Hou B. B., Xu G. L., Chin. J. Syn. Chem., 2014, 22(6), 781

    Google Scholar 

  5. Sun D., Lyu M., Lyu Z., Li Q., Yi B. X., China Pharmaceuticals, 2016, 25(8), 20

    CAS  Google Scholar 

  6. Guo C. B., Chen X. H., Yi X., Guo Z. R., Chu F. M., Cheng G. F., Acta Chimica Sinica, 2005, 63(9), 841

    CAS  Google Scholar 

  7. Song N., Li Y. X., Sun X., Qu F., Acta Pharmaceutica Sinica, 2004, 39(2), 105

    CAS  Google Scholar 

  8. Zhao X. L., Chen D. W., Formulation and Preparation Method of Eugenol Ibuprofen, CN1597656A, 2005

    Google Scholar 

  9. Liu Y. F., Zhang H., Peng D. M., Liao D. F., Preparation and Its Useway of 9-O-ibuprofen Berberine Ester, CN104817556A, 2015

    Google Scholar 

  10. Fan H. Y., Fu L., Wang S., Synthesis and Applicantion of Phillygenin Ibuprofen Ester, CN 105461731A, 2016

    Google Scholar 

  11. Wang J., Zhang X. R., Li Y., Chen L., Synthesis and Formulation of Ibuprofen Polyethylene Glycol Ester, CN 106008955A, 2016

    Google Scholar 

  12. Abraham N., Ada R., Edward N., Bernard L., Metabolically Stabi-lized Oxyalkylene Esters and Uses Thereof, WO 9840066A1, 1998

    Google Scholar 

  13. Ma T. H., Modern Medicine Health, 2011, 27(21), 3279

    Google Scholar 

  14. Yuan H. L., Hu J. M., Wei. Y. H., Zhang J. P., Zhou Y., Wu X. A., Chin. J. New Drugs, 2013, 22(3), 351

    CAS  Google Scholar 

  15. Song S. F., Luan Y. X., Lu F. S., Chem. Res. Chinese Universities, 2007, 23(6), 749

    Article  CAS  Google Scholar 

  16. Zhang L. Z., Ren Z. J., Lu A. M., Zhao Z., Xu W. Q., Bao Q. Q., Ding W. J., Yang C. L., Chem. Res. Chinese Universities, 2015, 31(2), 228

    Article  CAS  Google Scholar 

  17. Liu J. M., Xu J. H., Liu Y. Y., Xu X. S., Yuan Q. S., Chem. Res. Chi-nese Universities, 1998, 19(12), 1965

    Google Scholar 

  18. Sun Y. T., Zhang Y. P., Bi S. Y., Sun Y., Liu H., Zhai Y. J., Zhang H. Q., Chem. J. Chinese Universities, 2009, 30(6), 1095

    CAS  Google Scholar 

  19. Sun Y., Wang B., Chem. J. Chinese Universities, 2012, 33(4), 838

    CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. The Second Hospital, Jilin University, Changchun, 130022, P. R. China

    Bowei Wang

  2. Department of Organic Chemistry, College of Chemistry, Jilin University, Changchun, 130021, P. R. China

    Wanshi Hou, Yingnan Wang, Shaoheng Li & Zhiguang Song

  3. Department of Prosthodontics, Stomatology Hospital of Jilin University, Changchun, 130021, P. R. China

    Zhihui Liu

Authors
  1. Bowei Wang
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  2. Wanshi Hou
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  3. Yingnan Wang
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  4. Shaoheng Li
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  5. Zhihui Liu
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  6. Zhiguang Song
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Corresponding author

Correspondence to Zhiguang Song.

Additional information

Supported by the Development Project of the Pharmaceutical Industry of Jilin Province, China(Nos.20140311088YY, 20150311070YY, 20170307024YY), the Significant Science and Technology Project of Changchun City, China(No.2015054), the Key Science and Technology Project of Jilin Province, China(No.20140204066SF) and the Significant Science and Technology Item of ―Double Ten Project‖ of Changchun City, China(No.16SS12).

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Wang, B., Hou, W., Wang, Y. et al. Synthesis and pharmacodynamics of ibuprofen-1-acetoxyethyl ester. Chem. Res. Chin. Univ. 33, 569–573 (2017). https://doi.org/10.1007/s40242-017-7103-0

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  • DOI: https://doi.org/10.1007/s40242-017-7103-0

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