Abstract
Magnetic titanium dioxide core-shell nanoparticles(Fe3O4@TiO2 NPs) were synthesized as particles with appropriate size for intravenous injection. They subsequently were functionalized with p-aminothiophenol(PATP) to facilitate the covalent attachment of target drugs through azo coupling reaction, which can be universally observed in a variety of drugs containing phenols, anilines, and imidazoles. The proposed drug nanocarrier was designed to possess the ability to release drugs upon UV irradiation because of the photocatalytic property of the TiO2 shells. All the results indicate the potential application of the Fe3O4@TiO2 NPs in targeted drug delivery with greater chemical sta-bility and universality.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Saltzman W. M., Torchilin V. P., Drug Delivery Systems, Access Sciene, McGraw-Hill Education, 2014
Mishra B., Patel B. B., Tiwari S., Nanomedicine, 2010, 6, 9
Gao J., Gu H., Xu B., Acc. Chem. Res., 2009, 42, 1097
Dobson J., Drug Dev. Res., 2006, 67, 55
Roy P., Berger S., Schmuki P., Angew. Chem. Int. Ed., 2011, 50, 2904
Konstantinou I. K., Albanis T. A., Appl. Catal. B: Environ., 2004, 49, 1
Ma W. F., Zhang Y., Li L. L., You L. J., Zhang P., Zhang Y. T., Li J. M., Yu M., Guo J., Lu H. J., Wang C. C., ACS Nano, 2012, 6, 3179
Wan J., Li H., Chen K., Mater. Chem. Phys., 2009, 114, 30
Behrad F., Farimani M., Shahtahmasebi N., Rezaee Roknabadi M., Karimipour M., Eur. Phys. J. Plus, 2015, 130, 1
Cai L., Chen L., Zhang L., Lu G., He X., Zhang S., Sun H., Liu Z., Zhao B., ChemPlusChem, 2013, 78, 1437
Heath J. R., Davis M. E., Annu. Rev. Med., 2008, 59, 251
Perrault S. D., Walkey C., Jennings T., Fischer H. C., Chan W. C. W., Nano Lett., 2009, 9, 1909
Wang A. Z., Langer R., Farokhzad O. C., Annu. Rev. Med., 2012, 63, 185
Shen S., Wu L., Liu J., Xie M., Shen H., Qi X., Yan Y., Ge Y., Jin Y., Int. J. Pharm., 2015, 486, 380
Hua M. Y., Yang H. W., Liu H. L., Tsai R.Y., Pang S. T., Chuang K. L., Chang Y. S., Hwang T. L., Chang Y. H., Chuang H. C., Chuang C. K., Biomaterials, 2011, 32, 8999
Iida H., Takayanagi K., Nakanishi T., Osaka T., J. Colloid Interface Sci., 2007, 314, 274
Lee P. C., Meisel D., J. Phys. Chem., 1982, 86, 3391
Lata K., Mukherjee T. K., Biochim. Biophys. Acta, 2014, 1840, 1083
Yang L., Jiang X., Ruan W., Zhao B., Xu W., Lombardi J. R., J. Phys. Chem. C, 2008, 112, 20095
Han X. X., Pienpinijtham P., Zhao B., Ozaki Y., Anal. Chem., 2011, 83, 8582
Kneipp K., Moskovits M., Kneipp H., Surface-enhanced Raman Scattering: Physics and Applications, Springer, Berlin, 2006
Chen L., Han X. X., Yang J. X., Zhou J., Lu Z. C., Song W., Zhao B., Xu W. Q., Ozaki Y., Chem. Res. Chinese Universities, 2011, 27(4), 683
Huang Y. F., Zhu H. P., Liu G. K., Wu D. Y., Ren B., Tian Z. Q., J. Am. Chem. Soc., 2010, 132, 9244
Smith M. B., March J., Advanced Organic Chemistry: Reactions, Mechanisms, and Structure, 6th Ed., Wiley-Interscience, New York, 2007
Author information
Authors and Affiliations
Corresponding author
Additional information
Supported by the National Natural Science Foundationof China(No.81401717), the Scientific Research Foundation for Returned Overseas Scholars, Ministry of Education of China and the Development Program of the Science and Technology of Jilin Province, China(No.20130206011YY).
Electronic supplementary material
Rights and permissions
About this article
Cite this article
Cai, L., Li, J., Wang, S. et al. Functionalization of magnetic titanium dioxide for targeted drug delivery and UV-induced release. Chem. Res. Chin. Univ. 33, 294–297 (2017). https://doi.org/10.1007/s40242-017-6406-5
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s40242-017-6406-5