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Synthesis and antimicrobial activity of some new 4H-pyrrolo[1,2-a]benzimidazoles

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Abstract

Some new 4H-pyrrolo[1,2-a]benzimidazoles(2a–2f) have been synthesized. The structures of these compounds were confirmed by IR, 1H NMR, mass spectroscopy and elemental analysis. Compound 2a was further confirmed by X-ray diffraction. The in vitro antimicrobial activities of these compounds were determined against some gram-positive bacteria, gram-negative bacteria and fungi and their drug-resistant isolates in comparison with standard drugs. Antimicrobial results indicate that compounds 2c, 2d and 2e show moderately active antibacterial properties, their minimum inhibitory concentrations are from 12.5 μg/mL to 125 μg/mL. In the series, the most active compound against C. albicans is compound 2f with an MIC value of 31.25 μg/mL.

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Authors and Affiliations

  1. Jiangsu Key Laboratory of Biofunctional Materials, School of Chemistry and Materials Science, Nanjing Normal University, Nanjing, 210097, P. R. China

    Yuliang Jiang, Qiaorong Han, Ronghua Shen, Xinxin Zang & Bingxiang Wang

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  1. Yuliang Jiang
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  2. Qiaorong Han
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  3. Ronghua Shen
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  4. Xinxin Zang
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  5. Bingxiang Wang
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Corresponding author

Correspondence to Bingxiang Wang.

Additional information

Supported by the Natural Science Foundation of Jiangsu Education Committee, China(No.12KJD15008) and the National Natural Science Foundation of China(No.21202101).

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Jiang, Y., Han, Q., Shen, R. et al. Synthesis and antimicrobial activity of some new 4H-pyrrolo[1,2-a]benzimidazoles. Chem. Res. Chin. Univ. 30, 755–758 (2014). https://doi.org/10.1007/s40242-014-4147-2

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  • DOI: https://doi.org/10.1007/s40242-014-4147-2

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