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Synthesis of resveratrol analogs/stilbene derivatives and their nitric oxide inhibitory and radical scavenging activities

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Abstract

Sixteen resveratrol analogs(stilbene derivatives) including resveratrol were synthesized, in which hydroxystilbenes, naturally occurring polyphenols, showed protective effects against reactive oxygen and nitrogen species(ROS/RNS) and hexahydroxystilbene(16) displayed the strongest activities against NO and 1,1-diphenyl-2-picrylhydrazyl(DPPH) with IC50 values of 7.8 and 5.7 μmol/L, respectively.

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Authors and Affiliations

  1. Shenzhen Institute for Drug Control, Shenzhen, 518057, P. R. China

    Jue Wang & Tiejie Wang

  2. Shenzhen Key Laboratory of Microbial Genetic Engineering, College of Life Sciences, Shenzhen University, Shenzhen, 518060, P. R. China

    Xiaofan Li

  3. Shenzhen Key Laboratory of Chemical Biology, Graduate School at Shenzhen, Tsinghua University, Shenzhen, 518055, P. R. China

    Cunlong Zhang

Authors
  1. Jue Wang
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  2. Cunlong Zhang
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  3. Tiejie Wang
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  4. Xiaofan Li
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Corresponding author

Correspondence to Xiaofan Li.

Additional information

Supported by the Shenzhen Science and Technology Program, China(No.JCYJ20120830153011458), the Project of the Educational Commission of Guangdong Province of China(No.2013KJCX0164) and the Natural Science Foundation of Shenzhen Universitiy, China(No.00036159).

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Wang, J., Zhang, C., Wang, T. et al. Synthesis of resveratrol analogs/stilbene derivatives and their nitric oxide inhibitory and radical scavenging activities. Chem. Res. Chin. Univ. 30, 941–946 (2014). https://doi.org/10.1007/s40242-014-4120-0

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  • DOI: https://doi.org/10.1007/s40242-014-4120-0

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