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Involvement of Tight Junction Plaque Proteins in Cancer

  • Leaky Junctions in Cancer (Chris Capaldo, Section Editor)
  • Published:
Current Pathobiology Reports

Abstract

Purpose of Review

Here we review the molecular organization and protein–protein interactions of the following plaque proteins of tight junction (TJ): MAGI-1, -2 and -3, the polarity complex Par3/Par6/aPKC, afadin, MUPP1, PATJ, Pals1, cingulin, paracingulin, and JEAP. We analyze the status of these proteins in cancer tissue and their association to tumor suppressor proteins, kinases, and viral oncoproteins. Zonula occludens plaque proteins of the TJ are discussed separately in the preceding review within this issue.

Recent Findings

The expression of the above-mentioned TJ plaque proteins is frequently altered in cancer. However, while the loss of some of these proteins correlates with cancer development and low sensitivity to apoptosis, the overexpression of others is associated with poor patient survival rates. Some of these proteins are associated with tumor suppressor proteins like PTEN or to kinases activated in cancer like Src, while others are the target of oncoviral proteins or interact with signaling pathways involved in cell proliferation and transformation.

Summary

TJ present at the apical junctional complex of epithelial cells control the passage of ions and molecules through the paracellular route and block the movement of proteins and lipids within the plasma membrane from the apical to the basolateral surfaces. TJ are constituted by integral proteins linked to a vast group of plaque proteins, which form a scaffold associated with the actomyosin cytoskeleton. In cancerous tissues some of these plaque proteins are silenced while others are overexpressed.

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Acknowledgments

This work was supported by grant 237241 from the National Council for Science and Technology of Mexico (Conacyt). J. M., J. M. O. O., H. G. G., A. R. S., and O. V. S. are recipients of doctoral fellowships from Conacyt (262817, 233210, 282075, 233193, and 243103).

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  1. Department of Physiology, Biophysics and Neuroscience, Center for Research and Advanced Studies (Cinvestav), Ave IPN 2508, Mexico City, 07360, Mexico

    Lorenza Gonzalez-Mariscal, Jael Miranda, Jose Mario Ortega-Olvera, Helios Gallego-Gutierrez, Arturo Raya-Sandino & Orlando Vargas-Sierra

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  1. Lorenza Gonzalez-Mariscal
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Correspondence to Lorenza Gonzalez-Mariscal.

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Lorenza Gonzalez-Mariscal, Jael Miranda, Mario Ortega-Olvera, Helios Gallego-Gutierrez, Arturo Raya-Sandino, and Orlando Vargas-Sierra declare that they have no conflicts of interest.

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This article is part of the Topical Collection on Leaky Junctions in Cancer.

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Gonzalez-Mariscal, L., Miranda, J., Ortega-Olvera, J.M. et al. Involvement of Tight Junction Plaque Proteins in Cancer. Curr Pathobiol Rep 4, 117–133 (2016). https://doi.org/10.1007/s40139-016-0108-4

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