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The rationale for third trimester testing of vertical HIV transmission in neonates with CMV infection

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Abstract

We report on a late-preterm neonate with severe congenital cytomegalovirus (CMV) infection, refractory to antiviral therapy with ganciclovir. Subsequent immune diagnostics led to the finding of HIV infection at day 69, even though the mother tested negative for HIV in early pregnancy. Thus, in congenital CMV infection, HIV testing should be performed to elucidate maternal HIV seroconversion during late pregnancy. Our case strongly supports third trimester screening of HIV infection acquired during pregnancy, yet recommended only for women with traditional risk factors for HIV or living in an area of high HIV prevalence.

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Authors and Affiliations

  1. Department of Neonatology, Charité–Universitätsmedizin Berlin, Augustenburger Platz 1, 13353, Berlin, Germany

    Vinzenz Boos, Lars Garten, Malte Cremer, Christoph Bührer & Christof Dame

  2. Department of Pediatric Pneumology and Immunology, Charité–Universitätsmedizin Berlin, Berlin, Germany

    Cornelia Feiterna-Sperling

  3. Department of Neuropediatrics, Charité–Universitätsmedizin Berlin, Berlin, Germany

    Akosua Sarpong

  4. Department of Obstetrics, Charité–Universitätsmedizin Berlin, Berlin, Germany

    Katharina von Weizsäcker

Authors
  1. Vinzenz Boos
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  2. Cornelia Feiterna-Sperling
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  3. Akosua Sarpong
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  4. Lars Garten
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  5. Malte Cremer
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  6. Katharina von Weizsäcker
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  7. Christoph Bührer
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  8. Christof Dame
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Corresponding author

Correspondence to Vinzenz Boos.

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Boos, V., Feiterna-Sperling, C., Sarpong, A. et al. The rationale for third trimester testing of vertical HIV transmission in neonates with CMV infection. Infection 44, 555–557 (2016). https://doi.org/10.1007/s15010-016-0876-0

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  • DOI: https://doi.org/10.1007/s15010-016-0876-0

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