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Clostridium septicum gas gangrene in the orbit: a case report

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Abstract

Our report presents a case of Clostridium septicum gas gangrene in an unusual, orbital localization. The predisposing factors are typical: colon tumour and lymphatic malignancy. Most probably bacteria from the intestinal flora entered the bloodstream through the compromised intestinal wall and settled in the orbit resulting in the development of an abscess containing gas. At the site of the gas gangrene, an indolent B cell lymphoma was present. After surgery and antibiotic treatment, the patient healed from the C. septicum infection; but subsequently died as a consequence of the tumour.

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References

  1. Stevens DL, Musher DM, Watson DA, et al. Spontaneous, nontraumatic gangrene due to Clostridium septicum. Rev Infect Dis. 1990;12:286–96.

    Article  PubMed  CAS  Google Scholar 

  2. Kessler S, Schmid E, Pagon S. Gas gangrene panophthalmitis. Klin Monbl Augenheilkd. 1976;168:134–7.

    PubMed  CAS  Google Scholar 

  3. Jabaly-Habib HY, Muallm MS, Garzozi HJ. An intraorbital injury from an occult wooden foreign body. J Pediatr Ophthalmol Strabismus. 2002;39:300–2.

    PubMed  Google Scholar 

  4. Speiser P, Sutter R. Gas gangrene of the orbit. Klin Monbl Augenheilkd. 1988;192:141–2.

    Article  PubMed  CAS  Google Scholar 

  5. Kornbluth AA, Danzig JB, Bernstein LH. Clostridium septicum infection and associated malignancy. Report of 2 cases and review of the literature. Medicine (Baltimore). 1989;68:30–7.

    CAS  Google Scholar 

  6. Prinssen HM, Hoekman K, Burger CW. Clostridium septicum myonecrosis and ovarian cancer: a case report and review of literature. Gynecol Oncol. 1999;72:116–9.

    Article  PubMed  CAS  Google Scholar 

  7. Cannistra AJ, Albert DM, Frambach DA, Dreher RJ, Roberts L. Sudden visual loss associated with clostridial bacteraemia. Br J Ophthalmol. 1988;72:380–5.

    Article  PubMed  CAS  Google Scholar 

  8. Green MT, Font RL, Campbell JV, Marines HM. Endogenous Clostridium panophthalmitis. Ophthalmology. 1987;94:435–8.

    PubMed  CAS  Google Scholar 

  9. Insler MS, Karcioglu ZA, Naugle T Jr. Clostridium septicum panophthalmitis with systemic complications. Br J Ophthalmol. 1985;69:774–7.

    Article  PubMed  CAS  Google Scholar 

  10. Lindland A, Slagsvold JE. Binocular endogenous Clostridium septicum endophthalmitis. Acta Ophthalmol Scand. 2007;85:232–4.

    Article  PubMed  Google Scholar 

  11. Schickner DC, Yarkoni A, Langer P, Frohman L, Chen X, Folberg R, Del Priore LV. Panophthalmitis due to clostridium septicum. Am J Ophthalmol. 2004;137:942–4.

    Article  PubMed  Google Scholar 

  12. McHugh D, Moseley RP, Uttley D. Clostridium perfringens brain infection following a penetration wound of the orbit. J Neurol Neurosurg Psychiatry. 1987;50:241.

    Article  PubMed  CAS  Google Scholar 

  13. Crock GW, Heriot WJ, Janakiraman P, Weiner JM. Gas gangrene infection of the eyes and orbits. Br J Ophthalmol. 1985;69:143–8.

    Article  PubMed  CAS  Google Scholar 

  14. Fielden MP, Martinovic E, Ells AL. Hyperbaric oxygen therapy in the treatment of orbital gas gangrene. J AAPOS. 2002;6:252–4.

    Article  PubMed  Google Scholar 

  15. Schaaf RE, Jacobs N, Kelvin FM, et al. Clostridium septicum infection associated with colonic carcinoma and hematologic abnormality. Radiology. 1980;137:625–7.

    PubMed  CAS  Google Scholar 

  16. Ballard J, Bryant A, Stevens D, Tweten RK. Purification and characterization of the lethal toxin (alpha-toxin) of Clostridium septicum. Infect Immun. 1992;60:784–90.

    PubMed  CAS  Google Scholar 

  17. Kennedy CL, Krejany EO, Young LF, et al. The alpha-toxin of Clostridium septicum is essential for virulence. Mol Microbiol. 2005;57:1357–66.

    Article  PubMed  CAS  Google Scholar 

  18. Bodey GP, Rodriguez S, Fainstein V, Elting LS. Clostridial bacteremia in cancer patients. A 12-year experience. Cancer. 1991;67:1928–42.

    Article  PubMed  CAS  Google Scholar 

  19. Sjølin SU, Hansen AK. Clostridium septicum gas gangrene and an intestinal malignant lesion. A case report. J Bone Joint Surg Am. 1991;73:772–3.

    PubMed  Google Scholar 

  20. Koransky JR, Stargel MD, Dowell VR Jr. Clostridium septicum bacteremia. Its clinical significance. Am J Med. 1979;66:63–6.

    Article  PubMed  CAS  Google Scholar 

  21. King A, Rampling A, Wight DG, Warren RE. Neutropenic enterocolitis due to Clostridium septicum infection. J Clin Pathol. 1984;37:335–43.

    Article  PubMed  CAS  Google Scholar 

  22. Krautter U, Mory M, Mogler C, et al. Fatal Clostridium septicum infection in a patient with non-Hodgkin’s lymphoma undergoing multimodal oncologic therapy. Onkologie. 2009;32:115–8.

    Article  PubMed  Google Scholar 

  23. Ray D, Cohle SD, Lamb P. Spontaneous clostridial myonecrosis. J Forensic Sci. 1992;37:1428–32.

    PubMed  CAS  Google Scholar 

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Acknowledgments

We wish to thank our colleagues from the pathology, radiology and microbiology units for their work in the diagnostic process. We also acknowledge the help of our colleagues at the István Bugyi Hospital, Szentes, especially László Berente in the treatment of the patient and for letting us access the post-operative documentation.

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The authors certify that there is no actual or potential conflict of interest in relation to this article.

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Correspondence to I. Fejes.

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Fejes, I., Dégi, R. & Végh, M. Clostridium septicum gas gangrene in the orbit: a case report. Infection 41, 267–270 (2013). https://doi.org/10.1007/s15010-012-0366-y

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  • DOI: https://doi.org/10.1007/s15010-012-0366-y

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