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Mechanical endovascular thrombectomy for acute ischemic stroke: a retrospective multicenter study in Belgium

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An Erratum to this article was published on 04 November 2015

Abstract

Clinical trials have shown a beneficial effect of mechanical thrombectomy in acute ischemic stroke patients treated within six up to even 12 h after symptom onset. This treatment was already performed in selected hospitals in Belgium before completion of the randomized controlled trials. Outcome data on these procedures in Belgium have not been published. We performed a retrospective multicenter study of all patients with acute ischemic stroke treated with mechanical endovascular therapy in four hospitals in Belgium. Clinical outcomes, as measured by the modified Rankin Scale (mRS), site of arterial occlusion, reperfusion and the association between these variables were studied. The study included 80 patients: 65 patients with an occlusion in the anterior circulation and 15 with an occlusion in the posterior circulation. Good functional outcome (GFO) rates, defined as mRS 0–2 at 90 days, were 42 % in all patients, 44 % in anterior circulation stroke and 34 % in posterior circulation stroke. Reperfusion was achieved in 78 % of patients; more (100 %) in patients with posterior compared to patients with anterior circulation stroke (72 %; p = 0.02). The rate of GFO was greater in patients with reperfusion versus patients in whom reperfusion was not achieved (adjusted OR 8.2, 95 % CI 2.0–34.2). Symptomatic intracerebral hemorrhage was documented in 5 % of all patients. Endovascular treatment with mechanical devices for acute ischemic stroke in Belgium results in GFO and reperfusion rates similar to recently published results in the endovascular-treated arms of randomized clinical trials. Rates of symptomatic intracranial hemorrhage are low and comparable to other cohort studies and clinical trials.

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Acknowledgments

We would like to thank our colleagues of the neurology and neuroradiology department at the University Hospital Gent, Centre Hôpitalier Chrétien de Liege and Cliniques universitaires Saint-Luc in Brussels to provide clinical and radiological data. VT and RL are Senior Clinical Investigators of the FWO Flanders.

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Authors and Affiliations

  1. Department of Neurology, University Hospitals Leuven, 3000, Leuven, Belgium

    Niels Fockaert, Vincent Thijs & Robin Lemmens

  2. Department of Neurology, University Hospitals Gent, 9000, Ghent, Belgium

    Marieke Coninckx & Dimitri Hemelsoet

  3. Department of Radiology, University Hospitals Leuven, 3000, Leuven, Belgium

    Sam Heye

  4. Department of Vascular and Interventional Radiology, University Hospitals Gent, 9000, Ghent, Belgium

    Luc Defreyne

  5. Department of Interventional Neuroradiology, Centre Hospitalier Chrétien, 4000, Liège, Belgium

    Denis Brisbois

  6. Department of Neuroradiology, Cliniques Universitaires Saint-Luc, Université catholique de Louvain, Brussels, Belgium

    Pierre Goffette

  7. Department of Diagnostic and Interventional Neuroradiology, University Hospital Bern, Bern, Switzerland

    Jan Gralla & Pasquale Mordasini

  8. Department of Neurology, Cliniques Universitaires Saint-Luc, Université catholique de Louvain, 1200, Brussels, Belgium

    Andre Peeters

  9. Department of Neurology, Centre Hospitalier Chrétien, 4000, Liège, Belgium

    Philippe Desfontaines

  10. Department of Neurosciences, Experimental Neurology and Leuven Research Institute for Neuroscience and Disease (LIND), KU Leuven, University of Leuven, 3000, Leuven, Belgium

    Vincent Thijs & Robin Lemmens

  11. VIB, Vesalius Research Center, Laboratory of Neurobiology, 3000, Leuven, Belgium

    Vincent Thijs & Robin Lemmens

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  1. Niels Fockaert
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  2. Marieke Coninckx
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  3. Sam Heye
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  4. Luc Defreyne
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  6. Pierre Goffette
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  7. Jan Gralla
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  8. Pasquale Mordasini
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  9. Andre Peeters
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  12. Vincent Thijs
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  13. Robin Lemmens
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Corresponding author

Correspondence to Robin Lemmens.

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Conflict of interest

Jan Gralla reports grants from Covidien. All other authors have no disclosures.

Ethical approval

This study was performed in accordance with the ethical standards of the institutional research committees and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Fockaert, N., Coninckx, M., Heye, S. et al. Mechanical endovascular thrombectomy for acute ischemic stroke: a retrospective multicenter study in Belgium. Acta Neurol Belg 116, 7–14 (2016). https://doi.org/10.1007/s13760-015-0552-7

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  • DOI: https://doi.org/10.1007/s13760-015-0552-7

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