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[C6(MIm)2]2W10O32 catalyzed efficient one-pot pseudo-four component synthesis of AT-130 analogues under microwave irradiations

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Abstract

Di[1,6-bis(3-methylimidazolium-1-yl)hexane] decatangstate ([C6(MIm)2]2W10O32) was found to be a novel, powerful and effective catalyst for the preparation of N-benzoylglycine carbamides as derivatives of AT-130 via one-pot multicomponent reaction performed under microwave irradiations. The products were obtained in high to excellent yields, thus providing a unique strategy to the large-scale synthesis of these compounds.

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Acknowledgments

The authors are grateful to the ‘Center of Excellence of Chemistry of University of Isfahan (CECUI) and also the Research Council of the University of Isfahan for financial support of this work.

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Authors and Affiliations

  1. Department of Chemistry, University of Isfahan, Esfahān, 81746-73441, Iran

    Mahboubeh Rostami, Ahmad R. Khosropour, Valiollah Mirkhani, Iraj Mohammadpoor-Baltork, Majid Moghadam & Shahram Tangestaninejad

  2. Department of Medicinal Chemistry, School of Pharmacy, Isfahan University of Medical Sciences, Esfahān, 81745-359, Iran

    Mahboubeh Rostami

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  1. Mahboubeh Rostami
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  2. Ahmad R. Khosropour
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  3. Valiollah Mirkhani
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  6. Shahram Tangestaninejad
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Correspondence to Ahmad R. Khosropour.

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Rostami, M., Khosropour, A.R., Mirkhani, V. et al. [C6(MIm)2]2W10O32 catalyzed efficient one-pot pseudo-four component synthesis of AT-130 analogues under microwave irradiations. J IRAN CHEM SOC 11, 1493–1501 (2014). https://doi.org/10.1007/s13738-014-0420-z

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  • DOI: https://doi.org/10.1007/s13738-014-0420-z

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