Abstract
Uterine cervical cancer is increasingly prevalent among young Japanese women who are eager to preserve their fertility, and abdominal radical trachelectomy (ART) is often performed in patients with early-stage invasive lesions. Herein we present details of a 27-year-old woman with stage IB1 cervical cancer. Although the patient received ART, histopathological findings revealed a parametrial invasion. Hence, 3 courses of adjuvant chemotherapy with paclitaxel and carboplatin (TC) were administered, and the patient conceived spontaneously 44 months later. Rupture of the membrane occurred at 32 weeks and 4 days, and a 1822 g female baby was delivered by emergency cesarean section. The patient is alive without disease and her child is growing favorably. This case demonstrates the balance between preservation of fertility and curative adjuvant chemotherapy after ART.
Similar content being viewed by others
References
Ramirez PT, Schmeler KM, Soliman PT et al (2008) Fertility preservation in patients with early cervical cancer: radical trachelectomy. Gynecol Oncol 110:S25–S28
Sato S, Aoki D, Kobayashi H, Saito T et al (2011) Questionnaire survey of the current status of radical trachelectomy in Japan. Int J Clin Oncol 16:141–144
National Comprehensive Cancer Network Clinical Practice Guidelines for treatment of cancer (NCCN Clinical Practice Guidelines in Oncology™), Cervical Cancer. http://www.nccn.org/professionals/physician_gls/pdf/cervical.pdf
Baker TG (1971) Radiosensitivity of mammalian oocytes with particular reference to the human female. Am J Obstet Gynecol 110:746–761
Lee TY, Jeung YJ, Lee CJ et al (2013) Promising treatment results of adjuvant chemotherapy following radical hysterectomy for intermediate risk stage IB cervical cancer. Obstet Gynecol Sci 56:15–21
Hosaka M, Watari H, Kato T et al (2012) Clinical efficacy of paclitaxel/cisplatin as an adjuvant chemotherapy for patients with cervical cancer who underwent radical hysterectomy and systematic lymphadenectomy. J Surg Oncol 105:612–616
Hortobagyi GN, Buzdar AU, Marcus CE et al (1986) Immediate and long-term toxicity of adjuvant chemotherapy regimens containing doxorubicin in trials at M.D. Anderson Hospital and Tumor Institute. NCI Monogr 1986:105–109
Wallace WH, Shalet SM, Crowne EC et al (1989) Gonadal dysfunction due to cis-platinum. Med Pediatr Oncol 17:409–413
Maneschi F, Benedetti-Panici P, Scambia G et al (1994) Menstrual and hormone patterns in women treated with high-dose cisplatin and bleomycin. Gynecol Oncol 54:345–348
Tangir J, Zelterman D, Ma W et al (2003) Reproductive function after conservative surgery and chemotherapy for malignant germ cell tumors of the ovary. Obstet Gynecol 101:251–257
Tarumi W, Suzuki N, Takahashi N et al (2009) Ovarian toxicity of paclitaxel and effect on fertility in the rat. J Obstet Gynaecol Res 35:414–420
Pareja R, Rendón GJ, Sanz-Lomana CM et al (2013) Surgical, oncological, and obstetrical outcomes after abdominal radical trachelectomy—a systematic literature review. Gynecol Oncol 131:77–82
Nishio H, Fujii T, Sugiyama J et al (2013) Reproductive and obstetric outcomes after radical abdominal trachelectomy for early-stage cervical cancer in a series of 31 pregnancies. Hum Reprod 28:1793–1798
Acknowledgment
We would like to thank Enago (www.enago.jp) for the English language review.
Conflict of interest
The authors declare that they have no conflict of interest.
Author information
Authors and Affiliations
Corresponding author
About this article
Cite this article
Hanada, T., Tsuji, N., Miyata, H. et al. Successful delivery after abdominal radical trachelectomy followed by adjuvant chemotherapy for advanced invasive uterine cervical cancer: a case report and literature review. Int Canc Conf J 5, 9–12 (2016). https://doi.org/10.1007/s13691-015-0215-9
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s13691-015-0215-9