Abstract
Women infected with the human immunodeficiency virus face a higher risk of developing squamous cell carcinoma of the uterine cervix, but the association with glandular cervical lesions is not well known. A 39-year-old woman infected with human immunodeficiency virus was treated with conization for carcinoma in situ and adenocarcinoma in situ with complete resection. Fourteen years later at the age of 53, the squamous lesions had not progressed, but the glandular lesion developed into cervical adenocarcinoma. Increased risk of squamous cervical lesions in women with human immunodeficiency virus is related to immunosuppression. Local immunosuppression in cervical lesions may interact with persistent human papillomavirus infection. The interplay between human papilloma virus type 18 and local immunosuppression may be associated with development of cervical adenocarcinoma.
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Acknowledgments
We thank Yoshiaki Imamura, MD, whose comments and suggestions regarding cervical adenocarcinoma, particularly for diagnosis, were invaluable. The authors also thank the patient for permission to report her case.
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The authors declare that they have no conflict of interest.
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Tsuyoshi, H., Shinagawa, A., Kurokawa, T. et al. Cervical adenocarcinoma associated with persistent human papilloma and human immunodeficiency viral infections. Int Canc Conf J 3, 195–199 (2014). https://doi.org/10.1007/s13691-013-0147-1
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DOI: https://doi.org/10.1007/s13691-013-0147-1