Abstract
Investigation of the culture of basidiomycete Polyporus ellisii led to the isolation of a novel compound 3β,9α,15α-trihydroxy-(22E,24R)-10(5→4)-abeo-ergosta-6,8(14),22-trien-5-one (1) with a new 5/7/6/5 ring system of ergosterol skeleton. In addition, five new steroids, 5β,6β-epoxy-3β,7α,9α-trihydroxy-(22E,24R)-ergosta-8(14),22-dien-15-one (2), 5β,6β-epoxy-3β,7α-dihydroxy-(22E,24R)-ergosta-8(14),22-dien-15-one (3), 5α,6α-epoxy-3β,9α,15α-trihydroxy-(22E,24R)-ergosta-8(14),22-dien-7-one (4), 15α-acetoxy-(22E,24R)-ergosta-4,6,8(14),22-tetraen-3-one (5), 15β-methoxy-(22E,24R)-ergosta-4,6,8(14),22-tetraen-3-one (6), along with four known ergosterols (7–10), were obtained. All structures were elucidated based on 1D and 2D NMR spectral data. New compounds were evaluated for cytotoxicity against five human cancer cell lines, only compound 4 was found to exhibit a favorable cytotoxicity profile toward all tested tumor cell lines.
Graphical abstract
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
References
Gao, J. M.; Zhang, A. L.; Yao, H. Y. Zhongguo Zhongyao Zazhi2003, 28, 953–945.
Gao, J. M.; Hu, L.; Dong, Z. J.; Liu, J. K. Lipids2001, 36, 521–527.
Liu, J. K. Heterocycles2002, 57, 157–167.
Wang, F. Z.; Fang, Y. C.; Zhang, M.; Gu, Q. Q.; Zhu, W. M. Steroids2008, 73, 19–26.
Taro, A.; Makoto, T.; Atsushi, N. J. Nat. Prod.2007, 70, 1731–1740.
Ponce, M. A.; Ramirez, J. A.; Erra-Balsells, R. Photochem. Photobiol. Sci.2002, 1, 749–756.
Adler, J. H.; Young, M.; Nes, W, R. Lipids1977, 12, 364–366.
Wright J. L. C.; McInnes, A. G.; Shimizu, S. Can. J. Chem.1978, 56, 1898–1903.
John Wiley & Sons: Chichester, West Sussex, England, 2002, p 232.
Tayyab. A. M.; Lee, Y. M.; Jung, J. H. J. Nat. Prod.2006, 69, 131–134.
Bridgeman, J. E.; Cherry, P. C.; Woodgate, P. D. J. Chem. Soc.1970, 250–257.
Schulte, K. E.; Buecker, G.; Fachmann, H. Tetrahedron Lett.1968, 46, 4763–4764.
Author information
Authors and Affiliations
Corresponding author
Additional information
This article is published with open access at Springerlink.com
Electronic supplementary material
Rights and permissions
Open Access This article is distributed under the terms of the Creative Commons Attribution 2.0 International License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
About this article
Cite this article
Wang, S., Zhang, L., Liu, LY. et al. Six novel steroids from culture of basidiomycete Polyporus ellisii. Nat. Prod. Bioprospect. 2, 240–244 (2012). https://doi.org/10.1007/s13659-012-0058-4
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s13659-012-0058-4