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Diagnostic et traitement des mucormycoses en 2014

Diagnosis and Treatment of Mucormycosis in 2014

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Réanimation

Résumé

Les mucormycoses sont des infections fongiques invasives émergentes. Elles surviennent principalement chez des patients fortement immunodéprimés, mais aussi chez les diabétiques ou les patients traumatisés. Difficiles à diagnostiquer autant qu’à traiter, ces infections engagent rapidement le pronostic vital des patients. La chirurgie, l’amphotéricine B liposomale (AmBL) et la correction des facteurs de risque sont les trois piliers du traitement. Cette revue de la littérature développe le diagnostic et le traitement de ces infections à la lumière de leur physiopathologie.

Abstract

Mucormycosis is an emerging invasive fungal disease which occurs in immunocompromised patients and patients suffering from diabetes or trauma. Being difficult to diagnose and treat, these infections are rapidly lifethreatening. Surgery, liposomal amphotericin B, and reversal of risk factors are the cornerstones of mucormycosis treatments. This literature review focuses on diagnosis and treatment of mucormycosis based on its pathophysiology.

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Authors and Affiliations

  1. Unité de mycologie moléculaire, CNRS URA 3012, institut Pasteur, 28, rue du Docteur-Roux, F-75015, Paris, France

    B. Rammaert

  2. Service de maladies infectieuses et tropicales, hôpital Necker-Enfants-malades, AP-HP, centre d’infectiologie Necker-Pasteur, F-75015, Paris, France

    B. Rammaert

  3. Sorbonne Paris-Cité, Université Paris-Descartes, F-75006, Paris, France

    O. Lortholary

  4. IHU Imagine, F-75015, Paris, France

    O. Lortholary

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Correspondence to B. Rammaert.

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Rammaert, B., Lortholary, O. Diagnostic et traitement des mucormycoses en 2014. Réanimation 23, 309–316 (2014). https://doi.org/10.1007/s13546-014-0864-2

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