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The association between urodynamic findings and micro-vascular complications in type 2 diabetic patients with or without voiding symptoms

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Abstract

The aim of the present study was to evaluate the association between diabetic micro-vascular complications with the varied urodynamic manifestations of diabetic cystopathy in both asymptomatic and symptomatic subgroup of patients as shown in previous studies. A total of 63 type 2 diabetic patients are stratified into those with and without voiding dysfunction according to International Prostate Symptom Score (IPSS) score. Urine for albumin/creatinine ratio, direct ophthalmoscopy, and nerve conduction study (NCS) along with multichannel urodynamic study (UDS) were performed to detect diabetic micro-vascular complications. Correlation between urodynamic and micro-vascular complications was evaluated in patients with and without voiding symptoms and compared. Among the 63 patients (34 patients asymptomatic and 29 patients symptomatic), diabetic nephropathy, diabetic retinopathy, motor conduction study (MCS) abnormality, sensory conduction study (SCS) abnormality, and combined NCS abnormality were seen in 74.6, 49.2, 66.7, 65.1, and 65.1 % patients, respectively. On urodynamic study, diabetic cystopathy motor (DCM), diabetic cystopathy sensory (DCS), detrusor overactivity (DO), and bladder outlet obstruction (BOO) were found in 58.7, 54, 34.9, and 36.5 % cases, respectively. Among the micro-vascular complications, sensory nerve conduction studies (SCS), motor nerve conduction studies (MCS), and combined NCS abnormality had significant association with UDS abnormalities in diabetic patients. The association was stronger in symptomatic patients. A large proportion of type 2 diabetic patients have shown clinical and electrophysiologic evidence of neurologic dysfunction which can predict the presence or absence of DCS and DCM even in the asymptomatic stage. The correlation is stronger in the symptomatic group.

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Acknowledgments

We thank Dr. Ramesh Bhattacharya, Department of Neuromedicine, Calcutta National Medical College, for allowing us to do nerve conduction studies and help to interpret the same.

Ethical standards

This study was approved by the Institutional Ethics Committee of Calcutta National Medical College, Kolkata, India [Dated 3rd December, 2012].

Funding

This study was not funded.

Conflict of interest

Partha Pal, Sayantan Ray, Nabankur Ghosh, Sujoy Ghosh, Kaushik Biswas, Krishnendu Roy, Debabrata Mukherjee, and Dilip Karmakar declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Authors and Affiliations

  1. Department of General Medicine, Calcutta National Medical College and Hospital, Kolkata, 700014, West Bengal, India

    P. Pal & D. Mukherjee

  2. Department of Endocrinology and Metabolism, IPGMER and SSKM Hospital, Kolkata, 700020, West Bengal, India

    S. Ray, S. Ghosh & K. Biswas

  3. Department of Urology, Calcutta National Medical College and Hospital, Kolkata, 700014, West Bengal, India

    N. Ghosh & D. Karmakar

  4. Department of General Medicine, Medical College and Hospital, Kolkata, 700073, West Bengal, India

    K. Roy

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  1. P. Pal
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Correspondence to S. Ray.

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Pal, P., Ray, S., Ghosh, N. et al. The association between urodynamic findings and micro-vascular complications in type 2 diabetic patients with or without voiding symptoms. Int J Diabetes Dev Ctries 36, 103–112 (2016). https://doi.org/10.1007/s13410-015-0446-5

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  • DOI: https://doi.org/10.1007/s13410-015-0446-5

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