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Genetic variation of the porcine NR5A1 is associated with meat color

  • Animal Genetics • Original Paper
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Abstract

Because of the central role of Steroidogenic factor 1 in the regulation of the development and function of steroidogenic tissues, including the adrenal gland, we chose the encoding gene NR5A1 as a candidate for stress response, meat quality and carcass composition in the domestic pig. To identify polymorphisms of the porcine NR5A1 we comparatively sequenced the coding, untranslated and regulatory regions in four commercial pig lines. Single nucleotide polymorphisms could be found in the 3′ UTR and in an intronic enhancer, whereas no polymorphisms were detected in the proximal promoter and coding region. A subset of the detected polymorphisms was genotyped in Piétrain x (German Large White x German Landrace) and German Landrace pigs. For the same animals, carcass composition traits, meat quality characteristics and parameters of adrenal function were recorded. Associations with meat color were found for two of the discovered SNPs in Piétrain x (German Large White x German Landrace) and German Landrace pigs but no connections to parameters of adrenal function could be established. We conclude that NR5A1 variations influence meat color in a hypothalamus-pituitary-adrenal axis independent manner and that further regulatory regions need to be analyzed for genetic variations to understand the discovered effects.

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Acknowledgments

The authors thank Angela Garve and Marlies Fuchs for excellent technical help.

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Authors and Affiliations

  1. Leibniz Institute for Farm Animal Biology (FBN), Institute for Genome Biology, Wilhelm-Stahl-Allee 2, 18196, Dummerstorf, Germany

    Andreas Görres, Siriluck Ponsuksili, Klaus Wimmers & Eduard Muráni

Authors
  1. Andreas Görres
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  2. Siriluck Ponsuksili
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  3. Klaus Wimmers
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  4. Eduard Muráni
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Corresponding author

Correspondence to Eduard Muráni.

Additional information

Communicated by: Maciej Szydlowski

Electronic supplementary material

Below is the link to the electronic supplementary material.

Online Resource 1

Information on identified single nucleotide polymorphisms of the porcine NR5A1 (PDF 101 kb)

Online Resource 2

Association between the analyzed SNPs and parameters of meat quality and carcass composition (PDF 97 kb)

Online Resource 3

Estimated allele substitution effects of the analyzed SNPs (PDF 95 kb)

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Görres, A., Ponsuksili, S., Wimmers, K. et al. Genetic variation of the porcine NR5A1 is associated with meat color. J Appl Genetics 57, 81–89 (2016). https://doi.org/10.1007/s13353-015-0289-2

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  • DOI: https://doi.org/10.1007/s13353-015-0289-2

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