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Tryptase-positive mast cells and angiogenesis in keloids: a new possible post-surgical target for prevention

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Abstract

Literature data indicate that mast cells (MCs) are involved in angiogenesis through the release of several pro-angiogenetic factors among which tryptase, a serine protease stored in MC granules, is one of the most active. However, no data are available concerning the role of MCs during keloids’ angiogenesis. In this study, we evaluated the correlations of the number of MCs positive to tryptase (MCDPT) and microvascular density (MVD) within a series of 15 keloids and 10 normotrophic scars, by means of immunohistochemistry and image analysis methods. Data demonstrated a significant difference of MVD and MCDPT between keloids and normotrophic scars and a significant correlation between MVD and MCDPT in keloids. Our results suggest that tryptase-positive MCs might play a key role in keloids’ angiogenesis. In this context, several tryptase inhibitors might be clinically evaluated as a possible new anti-angiogenetic approach to prevent keloid formation after surgery.

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Acknowledgments

The authors would like to thank Prof. Giuseppe Donato for his support and technical help.

Conflict of interest

The authors declared no conflicts of interests.

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Authors and Affiliations

  1. Chair of Clinical Surgery, University of Catanzaro “Magna Graecia” Medical School, Viale Europa, Germaneto 88100, Catanzaro, Italy

    Michele Ammendola, Giuseppina Vescio, Giuseppe Sammarco & Rosario Sacco

  2. Department of Pathology, University of Catanzaro Medical School, Catanzaro, Italy

    Valeria Zuccalà & Andrea Amorosi

  3. Surgery Unit, National Cancer Institute Giovanni Paolo II, Bari, Italy

    Rosa Patruno & Severino Montemurro

  4. Chair of Pharmacology, Department of Health Science, University of Catanzaro Medical School, Catanzaro, Italy

    Emilio Russo & Giovambattista De Sarro

  5. Chair of Cardiovascular Disease, University of Catanzaro Medical School, Catanzaro, Italy

    Maria Luposella

  6. Interventional Radiology Unit with Integrated Section of Medical Oncology, National Cancer Institute, Giovanni Paolo II, Bari, Italy

    Girolamo Ranieri

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  1. Michele Ammendola
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Correspondence to Michele Ammendola.

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Ammendola, M., Zuccalà, V., Patruno, R. et al. Tryptase-positive mast cells and angiogenesis in keloids: a new possible post-surgical target for prevention. Updates Surg 65, 53–57 (2013). https://doi.org/10.1007/s13304-012-0183-y

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  • DOI: https://doi.org/10.1007/s13304-012-0183-y

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