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Association of heparan sulfate proteoglycans SDC1 and SDC4 polymorphisms with breast cancer in an Australian Caucasian population

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Tumor Biology

Abstract

Breast cancer is a common disease in both developing and developed countries with early identification and treatment improving prognosis and survival. Heparan sulfate proteoglycans (HSPGs) are key components of the extracellular matrix (ECM) that mediate cell adhesion, motility, proliferation, invasion and cell signalling. Members of the syndecan family of HSPGs have been identified to be involved in breast cancer progression through their varied interactions with a number of growth factors, ligands and receptors. Specifically, high expression levels of syndecan-1 (SDC1) have been demonstrated in more invasive breast tumours while elevated syndecan-4 (SDC4) levels have been identified to correspond with improved prognosis. With genetic changes in the syndecans and their association with breast cancers plausible, we examined two single nucleotide polymorphisms in SDC1 (rs1131351) and SDC4 (rs67068737) within an Australian Caucasian breast cancer case/control population. No association was found with SDC4 and breast cancer in our population. However, a significant association between SDC1 and breast cancer was identified in both our case/control population and in a replication cohort. When both populations were combined for analysis, this association became more significant (genotype, p = 0.0003; allele, p = 0.0001). This data suggests an increased risk of developing breast cancer associated with the presence of the C allele of the SDC1 rs1131351 single nucleotide polymorphism (SNP) and may provide a marker toward early breast cancer detection.

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Financial support

RKO is supported by an Australian Postgraduate Award stipend, and the authors wish to acknowledge the support of the Estate of the late Clem Jones AO, Cancer Council Queensland, Cancer Australia Grant (100639) and the Griffith Health Institute, Griffith University. SKC is an Australian Research Council Future Fellow. PHY is an NHMRC Early Career Fellow.

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Author information

Authors and Affiliations

  1. Genomics Research Centre, Institute for Health and Biomedical Innovation, Queensland University of Technology, Musk Avenue, Kelvin Grove, Brisbane, QLD, 4059, Australia

    Rachel K. Okolicsanyi, Anne Buffiere, Jose M. E. Jacinto, Diego Chacon-Cortes, Larisa M. Haupt & Lyn R. Griffiths

  2. AgroSup Dijon, 26 Boulevard Docteur Petitjean, 21000, Dijon, France

    Anne Buffiere

  3. Griffith Health Institute, Griffith University, Southport, QLD, Australia

    Suzanne K. Chambers & Philippa H. Youl

  4. Cancer Council Queensland, Brisbane, Australia

    Suzanne K. Chambers & Philippa H. Youl

  5. Health and Wellness Institute, Edith Cowan University, Perth, Australia

    Suzanne K. Chambers

  6. Centre for Clinical Research, University of Queensland, Brisbane, Australia

    Suzanne K. Chambers

  7. School of Public Health, Queensland University of Technology, Brisbane, Australia

    Philippa H. Youl

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  1. Rachel K. Okolicsanyi
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  2. Anne Buffiere
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  3. Jose M. E. Jacinto
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Correspondence to Lyn R. Griffiths.

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Rachel K. Okolicsanyi and Anne Buffiere are co-first authors.

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Okolicsanyi, R.K., Buffiere, A., Jacinto, J.M.E. et al. Association of heparan sulfate proteoglycans SDC1 and SDC4 polymorphisms with breast cancer in an Australian Caucasian population. Tumor Biol. 36, 1731–1738 (2015). https://doi.org/10.1007/s13277-014-2774-3

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  • DOI: https://doi.org/10.1007/s13277-014-2774-3

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