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Vascular Prostheses Based on Nanofibers from Aliphatic Copolyamide

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Abstract

Tubular grafts based on nanofibers of copolymer of ε-caprolactam and hexamethylendiaminadipate were obtained by the electrospinning method. The strength of materials based on the dry nanofibers was 6.2 MPa with elongation at break of 133%, or 7.5 MPa and 299% in saline, respectively. The pressure value at which liquid started seeping through the tube wall was P = 10 kPa. Absence of cytotoxicity was proved, as well as adhesion and proliferation of mesenchymal stem cells on the surface. Tubes with inner diameter of 1 mm were tested in vivo in rat abdominal aorta. A layer of endothelial cells was shown to form on the inner side of the prosthesis after 30 days. There was no evidence of stenosis or dilatation of the prosthesis after 14 months with observation of endothelial and subendothelial layers.

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Acknowledgments

The authors are grateful to the Russian Science Foundation under contract grant #14-03-00003. The authors would like to thank Prof. Textor Marcus for discussions and assistance in preparing the manuscript.

Conflict of interest

We declare that there is no conflict of interest with any organization regarding the material discussed in this manuscript.

Statement of Human Studies

No human studies in this study.

Statement of Animal Studies

We declare that the study submitted to Cardiovascular Engineering and Technology complies with the principles laid down in the Declaration of Helsinki. Animal research approved by the Animal Care and Use Committee (IACUC) of Gateway Medical Innovation Center (Shanghai, China).

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Authors and Affiliations

  1. Institute of Macromolecular Compounds, Russian Academy of Sciences, Saint Petersburg, Russia

    P. V. Popryadukhin, I. P. Dobrovolskaya, V. E. Yudin & E. M. Ivan’kova

  2. Saint-Petersburg State I.P. Pavlov Medical University, Saint Petersburg, Russia

    G. I. Popov, V. N. Vavilov & G. Yu. Yukina

  3. Saint-Petersburg State Polytechnical University, Saint Petersburg, Russia

    P. V. Popryadukhin, I. P. Dobrovolskaya, V. E. Yudin, E. M. Ivan’kova & I. O. Lebedeva

Authors
  1. P. V. Popryadukhin
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  2. G. I. Popov
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  3. I. P. Dobrovolskaya
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  4. V. E. Yudin
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  5. V. N. Vavilov
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  6. G. Yu. Yukina
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  7. E. M. Ivan’kova
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  8. I. O. Lebedeva
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Corresponding author

Correspondence to I. P. Dobrovolskaya.

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Associate Editor Ajit P. Yoganathan oversaw the review of this article.

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Popryadukhin, P.V., Popov, G.I., Dobrovolskaya, I.P. et al. Vascular Prostheses Based on Nanofibers from Aliphatic Copolyamide. Cardiovasc Eng Tech 7, 78–86 (2016). https://doi.org/10.1007/s13239-015-0234-x

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  • DOI: https://doi.org/10.1007/s13239-015-0234-x

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