Skip to main content
SpringerLink
Log in

An Overview on Fertility Outcome in Renal Transplant Recipients

  • Original Article
  • Published:
The Journal of Obstetrics and Gynecology of India Aims and scope Submit manuscript

Abstract

Background

The number of patients undergoing renal transplant are increasing with time. Most of these patients fall in the reproductive age group, who are going to conceive sooner or later. But there are few recipients who either are infertile before transplant or became infertile due to underlying renal pathology responsible for transplantation.

Objective

To study fertility outcome in female renal transplant recipients.

Materials and Methods

Study design: This is a retrospective study conducted at tertiary health center in Ahmedabad, from 2004 to 2014. Inclusion criteria: Renal transplant recipients in the reproductive age group (20–40 years of age) were followed up in gynecology outdoor patient department. Sample size: There were 211 female renal transplant recipients, out of which 113 (53.5 %) patients had complete family, 3 (1.41 %) patients were infertile, 16 (7.58 %) patients have conceived, 33 (15.63 %) patients were lost to follow-up and remaining 46 (21.8 %) did not try for pregnancy. Exclusion criteria: Unmarried patients, divorced and widow patients were excluded.

Results

Out of 19 patients, 16 patients conceived and 3 were infertile. The main cause of infertility in these patients was ovarian factor in 2 patients and tubal factor in 1 patient. Among 16 patients, 8 patients had missed abortion, 2 patients had preterm deliveries and 6 patients had term deliveries.

Conclusion

Peritransplant and preconceptional counseling plays an important role for renal transplant recipients to help them understand the effect of renal pathology and transplantation on their fertility. They can have good fertility and pregnancy outcome with optimum functioning graft.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

Similar content being viewed by others

References

  1. Anantharaman P, Schmidt RJ. Sexual function in chronic kidney disease. Adv Chronic Kidney Dis. 2007;14:119–25.

    Article  PubMed  Google Scholar 

  2. Raiz L, Davies EA, Ferguson RM. Sexual functioning following renal transplantation. Health Soc Work. 2003;28:264–72.

    Article  PubMed  Google Scholar 

  3. Fischer MJ, Lehnerz SD, Hebert JR, et al. Kidney disease is an independent risk factor for adverse fetal and maternal outcomes in pregnancy. Am J Kidney Dis. 2004;43:415–23.

    Article  PubMed  Google Scholar 

  4. Saha MT, Saha HH, Niskanen LK, et al. Time course of serum prolactin and sex hormones following successful renal transplantation. Nephron. 2002;92:735–7.

    Article  CAS  PubMed  Google Scholar 

  5. Rathi M, Ramachandran R. Sexual and gonadal dysfunction in chronic kidney disease: pathophysiology. Indian J Endocrinol Metab. 2012;16(2):214–9.

    Article  PubMed  PubMed Central  Google Scholar 

  6. Holley JL, Schmidt RJ, Bender FH, et al. Gynecologic and reproductive issues in women on dialysis. Am J Kidney Dis. 1997;29:685–90.

    Article  CAS  PubMed  Google Scholar 

  7. McKay D, Josephson M. Reproduction and transplantation: report on the AST consensus conference on reproductive issues and transplantation. Am J Transplant. 2005;5:1–8.

    Article  Google Scholar 

  8. Pezeshki M, Taherian AA, Gharavy M, et al. Menstrual characteristics and pregnancy in women after renal transplantation. Int J Gynaecol Obstet. 2004;85(2):119–25.

    Article  CAS  PubMed  Google Scholar 

  9. Lessan-Pezeshki M. Pregnancy after renal transplantation: points to consider. Nephrol Dial Transplant. 2002;17:703–7.

    Article  PubMed  Google Scholar 

  10. Leroy C, Rigot J-M, Leroy M, et al. Immunosuppressive drugs and fertility Orphanet. J Rare Dis. 2015;10:136.

    Article  Google Scholar 

  11. Josephson MA, McKay DB. Considerations in the medical management of pregnancy in transplant recipients. Adv Chronic Kidney Dis. 2007;14:156–67.

    Article  PubMed  Google Scholar 

  12. Yildirim Y, Uslu A. Pregnancy in patients with previous successful renal transplantation. Int J Gynaecol Obstet. 2005;90(3):198–202.

    Article  CAS  PubMed  Google Scholar 

  13. Tamaki M, Ami M, Kimata N, et al. Successful singleton pregnancy outcome resulting from in vitro fertilization after renal transplantation. Transplantation. 2003;75:1082–3.

    Article  PubMed  Google Scholar 

  14. Nouri K, Bader Y, Helmy S, et al. Live birth after in vitro fertilization and single embryo transfer in a kidney transplant patient: a case report and review of the literature. J Assist Reprod Genet. 2011;28(4):351–3.

    Article  PubMed  Google Scholar 

  15. Lockwood GM, Ledger WL, Barlow DH. Successful pregnancy outcome in a renal transplant patient following in vitro fertilization. Hum Reprod. 1995;10:1528–30.

    Article  CAS  PubMed  Google Scholar 

  16. Wang JX, Norman RJ, Kristiansson P. The effect of various infertility treatments on the risk of preterm birth. Hum Reprod. 2002;17:945–9.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Obstetrics and Gynaecology, Room No: 31, Institute of Kidney Diseases and Research Centre, Institute of Transplantation Sciences (IKDRC - ITS), B.J. Medical College, Civil Hospital Campus, Ahmedabad, 380016, India

    Vineet V. Mishra, Sakshi S. Nanda, Kavita Mistry, Sumesh Choudhary, Rohina Aggarwal & Bhumika M. Vyas

Authors
  1. Vineet V. Mishra
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Sakshi S. Nanda
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Kavita Mistry
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Sumesh Choudhary
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Rohina Aggarwal
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Bhumika M. Vyas
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Vineet V. Mishra.

Ethics declarations

Conflict of interest

None.

Ethical Approval

It is an observational study carried out at IKDRC, Ahmedabad. The study does not involve experiment on any animal or human being.

Informed Consent

Informed consent was obtained from all individual participants included in the study.

Additional information

Vineet V. Mishra, MBBS, MD, PhD, is a Professor and Head of Department, Obstetrics and Gynecology, Institute of Kidney Diseases and Research Centre, Institute of Transplantation Sciences (IKDRC-ITS), B.J. Medical College, Ahmedabad; Sakshi S. Nanda, MBBS, MS, is a Clinical Fellow, Obstetrics and Gynecology, Institute of Kidney Diseases and Research Centre, Institute of Transplantation Sciences (IKDRC-ITS), B.J. Medical College, Ahmedabad; Kavita Mistry, MBBS, MS, is a Clinical Fellow, Obstetrics and Gynecology, Institute of Kidney Diseases and Research Centre, Institute of Transplantation Sciences (IKDRC-ITS), B.J. Medical College, Ahmedabad; Sumesh Choudhary, MBBS, MS, is an Assistant Professor, Obstetric and Gynecology, Institute of Kidney Diseases and Research Centre, Institute of Transplantation Sciences (IKDRC-ITS), B.J. Medical College, Ahmedabad; Rohina Aggarwal, MBBS, MS, is an Associate Professor, Obstetric and Gynecology, Institute of Kidney Diseases and Research Centre, Institute of Transplantation Sciences (IKDRC-ITS), B.J. Medical College, Ahmedabad; Bhumika M. Vyas, MBBS, MS, is an Assistant Professor, Obstetric and Gynecology, Institute of Kidney Diseases and Research Centre, Institute of Transplantation Sciences (IKDRC-ITS), B.J. Medical College, Ahmedabad.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Mishra, V.V., Nanda, S.S., Mistry, K. et al. An Overview on Fertility Outcome in Renal Transplant Recipients. J Obstet Gynecol India 66 (Suppl 1), 330–334 (2016). https://doi.org/10.1007/s13224-016-0919-6

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s13224-016-0919-6

Keywords

Search

Navigation