Skip to main content
SpringerLink
Log in

Clinicopathological Factors of Cervical Nodal Metastasis and the Concept of Selective Lateral Neck Dissection in the Surgical Management of Carcinoma Larynx and Hypopharynx and Its Outcome

  • Original Article
  • Published:
Indian Journal of Surgical Oncology Aims and scope Submit manuscript

Abstract

To study the clinicopathological and molecular factors which correlate with nodal metastasis in laryngeal and hypopharyngeal carcinoma, a retrospective analysis of 170 patients who underwent surgery for laryngeal and hypopharyngeal carcinoma at RCC, Trivandrum from 2006 to 2010 was done. The pathological nodal stage and levels of involvement were correlated with the clinicopathologic features of the primary disease. Neck node positivity was significantly more for lesions of pyriform sinus lesion (61%), with thyroid cartilage erosion (56%) and with base tongue involvement (88%). Other clinicopathological factors have no impact on the disease-free survival and overall survival for patients with pathologically N0 status. Elective lateral neck dissection is advisable in cases with laryngeal cartilage erosion, pyriform sinus, supraglottis and base tongue involvement.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

Similar content being viewed by others

References

  1. Bray F, Ferlay J, Parkin DM, Pisani P (2001) International Agency for Research on Cancer. GLOBOCAN 2000: cancer incidence, mortality and prevalence worldwide. International Agency for Research on Cancer, Lyon

  2. Parkin DM, Pisani P, Ferlay J (1999) Estimates of the worldwide incidence of 25 major cancers in 1990. Int J Cancer 80:827–841

    Article  CAS  PubMed  Google Scholar 

  3. Cann IC, Fried MP, Rothman KJ (1985) Epidemiology of squamous cell cancer of the head and neck. Otolaryngol Clin N Am 18:367–388

    CAS  Google Scholar 

  4. Cattaruzza MS, Maisonneuve P, Boyle P (1996) Epidemiology of laryngeal cancer. Eur J Cancer B Oral Oncol 32:293–305

    Article  Google Scholar 

  5. Soussi T, Legros Y, Lubin R, Ory K, Schlichtholz B (1994) Multifactorial analysis of p53 alteration in human cancer: a review. Int J Cancer 57:1–9

    Article  CAS  PubMed  Google Scholar 

  6. Bartkova J, Lukas J, Mόller H, Strauss M, Gusterson B, Bartek J (1995) Abnormal patterns of D-type cyclin expression and G1 regulation in human head and neck cancer. Cancer Res 55:949–956

    CAS  PubMed  Google Scholar 

  7. American Joint Committee on Cancer (1992) Manual for staging of cancer, 4th edn. J.B. Lippincott, Philadelphia, pp 27–44

    Google Scholar 

  8. Esposito ED, Motta S, Cassiano B et al (2001) Occult lymph node metastases in supraglottic cancers of the larynx. Otolaryngol Head Neck Surg 124:253–257

    Article  CAS  PubMed  Google Scholar 

  9. Kuriakose MA, Trivedi NP (2009) Sentinel node biopsy in head and neck squamous cell carcinoma. Curr Opin Otolaryngol Head Neck Surg 17:100–110

    Article  PubMed  Google Scholar 

  10. Robbins KT, Clayman G, Levine PA (2002) Neck dissection classification update. Revisions proposed by the American Head and Neck Society and the American Academy of Otolaryngology-Head and Neck Surgery. Arch Otolaryngol Head Neck Surg 128:751–758

    Article  PubMed  Google Scholar 

  11. Shah JP (1990) Patterns of cervical lymph node metastasis from squamous carcinomas of the upper aerodigestive tract. Am J Surg 160:405–409

    Article  CAS  PubMed  Google Scholar 

  12. Mnejjaa M, Hammamia B, Bougachaa L, Chakrouna A, Charfeddinea I, Khabirb A, Boudaourab T, Ghorbel A (2010) Occult lymph node metastasis in laryngeal squamous cell carcinoma: therapeutic and prognostic impact, European Annals of Otorhinolaryngology. Head and Neck diseases 127:173–176

    Google Scholar 

  13. Bohannon IA, Desmond RA, Clemons L, Scott Magnuson J, Carroll WR, Rosenthal EL (2010) Management of the N0 neck in recurrent laryngeal squamous cell carcinoma. Laryngoscope 120:58–61

    Article  PubMed  Google Scholar 

  14. Pennings RJE, Marres HAM, den Heeten A Efficacy of diagnostic upper node evaluation during (salvage) laryngectomy for supraglottic carcinoma. Head & Neck. doi:10.1002/hedFebruary2009

  15. Lawson G, Matar N, Nollevaux MC, Jamart J, Krug B, Delos M, Remacle M, Borght TV (2010) Reliability of sentinel node technique in the treatment of N0 supraglottic laryngeal cancer. Laryngoscope 120(11):2213–2217

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Surgical Oncology, Regional Cancer Center, Thiruvanathapuram, India

    Elizabeth Mathew Iype,  Santhosh Kumar N, Sreekanth S. Kumar, Bipin T. Varghese & Jaya C. Jose

Authors
  1. Elizabeth Mathew Iype
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Santhosh Kumar N
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Sreekanth S. Kumar
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Bipin T. Varghese
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Jaya C. Jose
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Santhosh Kumar N.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Iype, E.M., Santhosh Kumar N, Kumar, S.S. et al. Clinicopathological Factors of Cervical Nodal Metastasis and the Concept of Selective Lateral Neck Dissection in the Surgical Management of Carcinoma Larynx and Hypopharynx and Its Outcome. Indian J Surg Oncol 9, 24–27 (2018). https://doi.org/10.1007/s13193-017-0666-x

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s13193-017-0666-x

Keywords

Search

Navigation