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Influence of Standardized Extract Ginkgo biloba EGb761® Towards Quality of Life Indicators in Patients with Diabetes Mellitus Type 2

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Abstract

Cognitive impairment in patients with type 2 diabetes mellitus (DM-2) currently attracts a lot of attention due to their impact on quality of life and the effectiveness of treatment. The aim of research is to find the most effective medication which influences the cognitive functions positively. The research included 120 patients with average age of 61.22 ± 8.6 and average DM-2 duration of 10.84 ± 8.2 years. Mini Mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA test), Trail Making Test (TMT), Parts A and B, Hospital Anxiety and Depression Scale (HADS), and The Short Form-36 (SF-36) were used. It was revealed that patients with DM type 2 had cognitive dysfunction generally presented by mild cognitive impairment. Patients with DM-2 have an early manifestation of cognitive impairment. After the initial estimation of indicators, all the patients were taking standardized extract Ginkgo biloba (EGb 761®) in the dose 240 mg a day for 6 months. Estimation of all the indicators after 3 and 6 months of treatment showed significant cognitive improvement. By matching the available experimental and clinical data, we can conclude that in the setting of DM-2 EGb 761®, by producing a positive effect towards various factors which results from insulin resistance of the brain, improves functions of the brain, which manifests in improvement of main QoL indicators in DM-2.

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References

  1. Global report on diabetes. [Internet]. Apps.who.int. 2018 [cited 27 March 2018]. Available from: http://apps.who.int/iris/bitstream/10665/204871/1/9789241565257_eng.pdf.

  2. Quality of Life Assessment: an annotated bibliography [Internet]. Apps.who.int. 1994 [cited 27 March 2018]. Available from: http://apps.who.int/iris/bitstream/10665/61629/1/WHO_MNH_PSF_94.1.pdf.

  3. Bosic-Zivanovic, D., Medic-Stojanoska, M., & Kovacev-Zavisic, B. (2012). The quality of life in patients with diabetes mellitus type 2. Vojnosanitetski Pregled, 69(10), 858–863.

    Article  Google Scholar 

  4. Esin, R., Khairullin, I., Esin, O., & Abakumova, A. (2016). Quality of life in patients with type 2 diabetes mellitus. BioNanoScience, 6(4), 502–507.

    Article  Google Scholar 

  5. Folstein, M., Folstein, S., & McHugh, P. (1975). Mini-mental state. Journal of Psychiatric Research, 12(3), 189–198.

    Article  Google Scholar 

  6. MoCA Montreal—cognitive assessment [Internet]. MoCA Montreal—cognitive assessment. [cited 27 March 2018]. Available from: http://www.mocatest.org/wp-content/uploads/2015/tests-instructions/MoCA-Test-Russian_2010.pdf.

  7. Atkinson, T., & Ryan, J. (2007). The use of variants of the trail making test in serial assessment. Journal of Psychoeducational Assessment, 26(1), 42–53.

    Article  Google Scholar 

  8. Zigmond, A., & Snaith, R. (1983). The hospital anxiety and depression scale. Acta Psychiatrica Scandinavica, 67(6), 361–370.

    Article  Google Scholar 

  9. Ware, J., Snow, K., Kosinski, M., & Gandek, B. (1997). SF-36 health survey. Boston: The Health Institute, New England Medical Center.

    Google Scholar 

  10. Lim, S., Yoon, J., Kang, S., Choi, S., Cho, B., Kim, M., et al. (2011). EGb761, a Ginkgo biloba extract, is effective against atherosclerosis in vitro, and in a rat model of type 2 diabetes. PLoS One, 6(6), e20301.

    Article  Google Scholar 

  11. Silva, G. (2011). Neuroprotective action of Ginkgo biloba on the enteric nervous system of diabetic rats. World Journal of Gastroenterology, 17(7), 898.

    Article  Google Scholar 

  12. Saini, A., Taliyan, R., & Sharma, P. (2014). Protective effect and mechanism of Ginkgo biloba extract-EGb 761 on STZ-induced diabetic cardiomyopathy in rats. Pharmacognosy Magazine, 10(38), 172.

    Article  Google Scholar 

  13. Welt, K., Weiss, J., Martin, R., Hermsdorf, T., Drews, S., & Fitzl, G. (2007). Ginkgo biloba extract protects rat kidney from diabetic and hypoxic damage. Phytomedicine, 14(2–3), 196–203.

    Article  Google Scholar 

  14. Wei, Z., Wei, Z., ShanShan, X., & QiChong, X. (2013). GW24-e2480 Ginkgo biloba attenuates oxidative DNA damage of human umbilical vein endothelial cells induced by intermittent high glucose. Heart, 99(Suppl 3), A95.2–A9A96.

    Article  Google Scholar 

  15. Liu, X., Hao, W., Qin, Y., Decker, Y., Wang, X., Burkart, M., et al. (2015). Long-term treatment with Ginkgo biloba extract EGb 761 improves symptoms and pathology in a transgenic mouse model of Alzheimer’s disease. Brain, Behavior, and Immunity, 46, 121–131.

    Article  Google Scholar 

  16. Xie, H., Wang, J., Yau, L., Liu, Y., Liu, L., Han, Q., et al. (2014). Catechins and procyanidins of Ginkgo biloba show potent activities towards the inhibition of β-amyloid peptide aggregation and destabilization of preformed fibrils. Molecules, 19(4), 5119–5134.

    Article  Google Scholar 

  17. Talbot, K., Wang, H., Kazi, H., Han, L., Bakshi, K., Stucky, A., et al. (2012). Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline. Journal of Clinical Investigation, 122(4), 1316–1338.

    Article  Google Scholar 

  18. Blazquez, E., Velazquez, E., Hurtado-Carneiro, V., Ruiz-Albusac, J. (2014). Insulin in the brain: its pathophysiological implications for states related with central insulin resistance, type 2 diabetes and Alzheimer’s disease. Frontiers in Endocrinology, 5.

  19. Derakhshan, F., & Toth, C. (2013). Insulin and the brain. Current Diabetes Reviews, 9(2), 102–116.

    Google Scholar 

  20. Cong, W., Tao, R., Tian, J., Zhao, J., Liu, Q., & Ye, F. (2011). EGb761, an extract of Ginkgo biloba leaves, reduces insulin resistance in a high-fat-fed mouse model. Acta Pharmaceutica Sinica B, 1(1), 14–20.

    Article  Google Scholar 

  21. EGb 761 prevented palmitate-induced insulin resistance in L6 myotubes via the inhibition of stress kinases, NF-[kappa]B, and PK [theta] | American Diabetes Association [Internet]. Professional.diabetes.org. 2007 [cited 30 March 2018]. Available from: https://professional.diabetes.org/abstract/egb-761-prevented-palmitate-induced-insulin-resistance-l6-myotubes-inhibition-stress.

  22. Kudolo, G., Wang, W., Javors, M., & Blodgett, J. (2006). The effect of the ingestion of Ginkgo biloba extract (EGb 761) on the pharmacokinetics of metformin in non-diabetic and type 2 diabetic subjects—a double blind placebo-controlled, crossover study. Clinical Nutrition, 25(4), 606–616.

    Article  Google Scholar 

  23. Zhang, Y., Zhao, Y., Pan, F., & Zhang, P. (2016). EGb761 attenuates depressive-like behaviours induced by long-term light deprivation in C57BL/6J mice through inhibition of NF-κB-IL-6 signalling pathway. Central European Journal of Immunology, 4, 350–357.

    Article  Google Scholar 

  24. Rojas, P., Serrano-García, N., Medina-Campos, O., Pedraza-Chaverri, J., Ögren, S., & Rojas, C. (2011). Antidepressant-like effect of a Ginkgo biloba extract (EGb761) in the mouse forced swimming test: role of oxidative stress. Neurochemistry International, 59(5), 628–636.

    Article  Google Scholar 

  25. Yeh, K., Wu, C., Tai, M., & Tsai, Y. (2011). Ginkgo biloba extract enhances noncontact erection in rats: the role of dopamine in the paraventricular nucleus and the mesolimbic system. Neuroscience, 189, 199–206.

    Article  Google Scholar 

  26. Kehr, J., Yoshitake, S., Ijiri, S., Koch, E., Nöldner, M., & Yoshitake, T. (2012). Ginkgo biloba leaf extract (EGb 761®) and its specific acylated flavonol constituents increase dopamine and acetylcholine levels in the rat medial prefrontal cortex: possible implications for the cognitive enhancing properties of EGb 761®. International Psychogeriatrics, 24(S1), S25–S34.

    Article  Google Scholar 

  27. Preuss, U., Bachinskaya, N., Kaschel, R., Wong, J., Hoerr, R., & Gavrilova, S. (2013). 1689—Ginkgo biloba extract EGb 761 in mild cognitive impairment with neuropsychiatric symptoms: a randomized placebo-controlled trial. European Psychiatry, 28, 1.

    Article  Google Scholar 

  28. Gavrilova, S., Preuss, U., Wong, J., Hoerr, R., Kaschel, R., & Bachinskaya, N. (2014). Efficacy and safety of Ginkgo biloba extract EGb 761®in mild cognitive impairment with neuropsychiatric symptoms: a randomized, placebo-controlled, double-blind, multi-center trial. International Journal of Geriatric Psychiatry, 29(10), 1087–1095.

    Article  Google Scholar 

  29. Hoerr, R., Nacu, A. (2016). Neuropsychiatric symptoms in dementia and the effects of Ginkgo biloba extract EGb 761® treatment: Additional results from a 24-week randomized, placebo-controlled trial. Open Access Journal of Clinical Trials, 1.

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Funding

The reported study was supported by the program of competitive growth of Kazan Federal University.

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Authors and Affiliations

  1. Laboratory of Clinical Linguistics, Kazan Federal University, 2 Tatarstan str., Kazan, Russia, 420008

    Radiy Esin, Oleg Esin & Ilshat Khayrullin

  2. Department of Neurology and Manual Therapy, Kazan State Medical Academy, 11 Mushtari str., Kazan, Russia, 4200124

    Radiy Esin

  3. Department of Fundamental Basis of Clinical Medicine, Kazan Federal University, 56 K.Marks str., Kazan, Russia, 420012

    Radiy Esin & Oleg Esin

  4. Department of Russian Language and Applied Linguistics, Kazan Federal University, 2 Tatarstan str., Kazan, Russia, 420008

    Radiy Esin & Oleg Esin

Authors
  1. Radiy Esin
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  2. Oleg Esin
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Correspondence to Radiy Esin.

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Esin, R., Esin, O. & Khayrullin, I. Influence of Standardized Extract Ginkgo biloba EGb761® Towards Quality of Life Indicators in Patients with Diabetes Mellitus Type 2. BioNanoSci. 8, 916–923 (2018). https://doi.org/10.1007/s12668-018-0550-3

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  • DOI: https://doi.org/10.1007/s12668-018-0550-3

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