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The Effect of l-Ascorbate 1-(2-Hydroxyethyl)-4,6-Dimethyl-1,2-Dihydropyrimidin-2-One on the Regeneration of the Planarian Girardia tigrina

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Abstract

The effect of l-ascorbate 1-(2-hydroxyethyl)-4,6-dimethyl-1,2-dihydropyrimidine-2-one, a co-crystal of Xymedon with ascorbic acid, derived from pyrimidine on the regeneration process of the planarian Girardia tigrina (Girard, 1850) has been investigated. Being a co-crystal of Xymedon with ascorbic acid, the preparation is characterized by the improved properties compared to Xymedon. The new preparation falls within the group of hepatoprotectors capable of liver regeneration in response to various destructive factors. It has been shown that the new preparation at different concentration levels can inhibit planarian head regeneration. Two combinations of the test substance were used in the work: a neat form of the preparation; a mixture of the preparation with Na2CO3 to reduce the acidity of the test substance. The neat preparation showed a statistically insignificant tendency to an increase in the regeneration of G. tigrina planarians. When mixed with Na2CO3, the preparation inhibited the regeneration of G. tigrina planarians. G. tigrina planarians is a popular model for studying regeneration processes and stem cell proliferation.

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Funding

The research was supported by the Russian Science Foundation (project no. 14-50-00014).

The images of the planarians were obtained using microscopes of Interdisciplinary Center for Analytical Microscopy of Kazan Federal University.

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Authors and Affiliations

  1. Kazan Federal University, 18 Kremlevskaya str, Kazan, 420008, Russia

    Andrey Porfiriev, Ksenia Yuganova, Alexander Belyaev & Vladimir Zobov

  2. Laboratory of Biological and Chemical Researches of A.E, Arbuzov Institute of Organic and Physical Chemistry Kazan Scientific Centre Russian Academy of Sciences, 8 Arbuzova str, Kazan, 420088, Russia

    Andrey Porfiriev, Alexandra Vyshtakaliuk, Vladimir Zobov & Vyacheslav Semenov

Authors
  1. Andrey Porfiriev
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  2. Ksenia Yuganova
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  3. Alexander Belyaev
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  4. Alexandra Vyshtakaliuk
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  5. Vladimir Zobov
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  6. Vyacheslav Semenov
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Correspondence to Andrey Porfiriev.

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Porfiriev, A., Yuganova, K., Belyaev, A. et al. The Effect of l-Ascorbate 1-(2-Hydroxyethyl)-4,6-Dimethyl-1,2-Dihydropyrimidin-2-One on the Regeneration of the Planarian Girardia tigrina . BioNanoSci. 7, 570–573 (2017). https://doi.org/10.1007/s12668-017-0451-x

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  • DOI: https://doi.org/10.1007/s12668-017-0451-x

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