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Abnormal Ultrastructure of the Platelet Plasma Membrane in Systemic Lupus Erythematosus

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Abstract

Systemic lupus erythematosus (SLE) is an autoimmune disease in which the body’s immune system mistakenly attacks healthy tissue. It can affect the skin, joints, kidneys, brain, and other organs. Blood cells, including platelets, are also involved in SLE and contribute to the pathogenesis of disease. We studied ultrastructure of platelets isolated from the blood of SLE patients and found that the plasma membrane was rough and shaggy compared to the normally smooth cell surface. These changes in the membrane morphology increased with the disease severity and were more pronounced when SLE was associated with the antiphospholipid syndrome, suggesting that platelets are strongly affected by the immune reactions underlying SLE.

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References

  1. Biolard, E., Blanco, P., Nigrovic, A. (2012). Platelets: active players in the pathogenesis of arthritis and SLE. Nature, 8, 534–542.

    Google Scholar 

  2. Vikerfors, A., Johansson, A. B., Gustafsson, J. T., Jonsen, A., Leonard, D. (2013). Clinical manifestations and anti-phospholipid antibodies in 712 patients with systemic lupus erythematosus: evaluation of two diagnostic assays. Rheumatology (Oxford), 52, 501–509.

    Article  Google Scholar 

  3. Ponomarevaa, A. A., Nevzorova, T. A., Mordakhanova, E. R., Andrianova, I. A., Litvinov, R. I. (2016). Structural characterization of platelets and platelet microvesicles. Tissue Biology, 10(3), 217–226.

    Article  Google Scholar 

  4. Macchi, L., Rispal, P., Clofent-Sanchez, G., Pellegrin, J. L., Nurden, P., Leng, B., et al. (1997). Anti-platelet antibodies in patients with systemic lupus erythematosus and the primary antiphospholipid antibody syndrome: their relationship with the observed thrombocytopenia. British Journal of Haematology, 98, 336–341.

    Article  Google Scholar 

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Acknowledgments

This work was supported by the Program for Competitive Growth of Kazan Federal University.

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Authors and Affiliations

  1. Kazan Federal University, 18 Kremlyovskaya St, Kazan, 42008, Russia

    Izabella A. Andrianova, Anastasia A. Ponomareva, Elmira R. Mordakhanova & Rustem I. Litvinov

  2. Kazan Institute of Biochemistry and Biophysics, 2 Lobachevsky St, Kazan, 42008, Russia

    Anastasia A. Ponomareva

  3. Kazan State Medical University, 49 Butlerov St, Kazan, 420012, Russia

    Adelia N. Maksudova

  4. University of Pennsylvania School of Medicine, 421 Curie Blvd, Philadelphia, PA, 19104, USA

    Rustem I. Litvinov

Authors
  1. Izabella A. Andrianova
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  2. Anastasia A. Ponomareva
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  3. Elmira R. Mordakhanova
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  4. Adelia N. Maksudova
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  5. Rustem I. Litvinov
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Corresponding author

Correspondence to Rustem I. Litvinov.

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The study was approved by the Ethical Committee of Kazan State Medical University.

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Andrianova, I.A., Ponomareva, A.A., Mordakhanova, E.R. et al. Abnormal Ultrastructure of the Platelet Plasma Membrane in Systemic Lupus Erythematosus. BioNanoSci. 6, 361–363 (2016). https://doi.org/10.1007/s12668-016-0239-4

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  • DOI: https://doi.org/10.1007/s12668-016-0239-4

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