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Prevalence and predictors of abnormal bone mineral metabolism in recently diagnosed adult celiac patients

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Abstract

Background and Aims

This study aimed to evaluate the prevalence of low bone mineral density (BMD) in recently diagnosed adult celiac patients and to identify the factors associated with this.

Methods

We investigated 54 newly diagnosed adult celiac patients between February 2008 and April 2009. BMD was measured in all patients and its correlation with clinical and biochemical parameters was analyzed.

Results

Fifty-four (24 male) newly diagnosed celiac patients with a mean±SD age of 30.6 ± 9.3 years (range 18–50) were included. Thirty-nine (72.2 %) presented with intestinal symptoms, and the rest with extraintestinal symptoms. Low vitamin D levels were seen in 11 (20.3 %) patients and elevated iPTH (secondary hyperparathyroidism) in 12 (22.2 %) patients. Twenty-one (39 %) patients had normal BMD, 23 (43 %) had osteopenia (T-score −1 to −2.5), and 10 (18 %) patients had osteoporosis (T-score <−2.5). A statistically significant association was seen between BMD and age of onset, duration of illness, serum tTGA levels, serum vitamin D levels, and histopathological changes.

Conclusions

Low BMD is common in newly diagnosed adult celiac patients with approximately one fifth of them having osteoporosis. BMD should be measured in all newly diagnosed celiac patients and calcium and vitamin D supplementation included in the treatment regimen.

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Conflict of interest

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Authors and Affiliations

  1. Department of Gastroenterology, Postgraduate Institute of Medical Education and Research, Chandigarh, 160 012, India

    Sudheer D. Chakravarthi, Kapil Jain, Rakesh Kochhar, Usha Dutta, Chander K. Nain & Kartar Singh

  2. Department of Endocrinology, Postgraduate Institute of Medical Education and Research, Chandigarh, 160 012, India

    Sanjay K. Bhadada & Anil Bhansali

  3. Department of Radiodiagnosis and Imaging, Postgraduate Institute of Medical Education and Research, Chandigarh, 160 012, India

    Niranjan Khandelwal

Authors
  1. Sudheer D. Chakravarthi
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  2. Kapil Jain
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  3. Rakesh Kochhar
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  4. Sanjay K. Bhadada
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  5. Niranjan Khandelwal
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  6. Anil Bhansali
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  7. Usha Dutta
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  9. Kartar Singh
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Corresponding author

Correspondence to Rakesh Kochhar.

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Chakravarthi, S.D., Jain, K., Kochhar, R. et al. Prevalence and predictors of abnormal bone mineral metabolism in recently diagnosed adult celiac patients. Indian J Gastroenterol 31, 165–170 (2012). https://doi.org/10.1007/s12664-012-0216-y

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  • DOI: https://doi.org/10.1007/s12664-012-0216-y

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