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Association Between Insulin-Like Growth Factor-1 and Frailty Among Older Adults

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The journal of nutrition, health & aging

Abstract

Objectives

Frailty is a course experienced in advanced aging. Identification of a biological factor associated with frailty is required. Although serum insulin-like growth factor-1 (IGF-1) is a potential factor related with frailty, consensus has not been reached regarding this relationship. This study aimed to investigate the association between IGF-1 and frailty in older adults.

Design

Cross-sectional study.

Setting

Cohort study that was part of the “National Center for Geriatrics and Gerontology–Study of Geriatric Syndromes.”

Participants

The study participants were 4133 older adults (mean age, 71.8 ± 5.4 years).

Measurements

We assessed serum IGF-1 levels and frailty status and collected demographic variables, including cognitive function, as covariates.

Results

Frailty and pre-frailty were present in 274 subjects (7%) and 1930 subjects (47%), respectively. Subjects were divided into four groups based on quartiles of IGF-1 levels. Multinomial logistic analysis showed that the lowest group had significant odds of pre-frailty (crude model: odds ratio [OR] 1.58, 95% confidence interval [CI] 1.30–1.90, p <.001; adjusted model: OR 1.38, 95% CI 1.13–1.68, p =.002) and frailty (crude model: OR 3.42, 95% CI 2.38-4.92, p <.001; adjusted model: OR 1.54, 95% CI 1.02–2.32, p =.039), compared with the highest group.

Conclusion

Lower serum IGF-1 levels were independently related with frailty in older adults.

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Author information

Authors and Affiliations

  1. Department of Preventive Gerontology, Center for Gerontology and Social Science, National Center for Geriatrics and Gerontology, 7-430, Morioka, Obu, Aichi, 474-8511, Japan

    Takehiko Doi, H. Makizako, K. Tsutsumimoto, R. Hotta, S. Nakakubo, K. Makino & H. Shimada

  2. Japan Society for the Promotion of Science, Tokyo, Japan

    K. Tsutsumimoto

  3. National Center for Geriatrics and Gerontology, Obu, Aichi, Japan

    T. Suzuki

  4. Institute for Gerontology, J.F. Oberlin University, Tokyo, Japan

    T. Suzuki

Authors
  1. Takehiko Doi
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  2. H. Makizako
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  3. K. Tsutsumimoto
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  4. R. Hotta
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  5. S. Nakakubo
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  7. T. Suzuki
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  8. H. Shimada
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Correspondence to Takehiko Doi.

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Doi, T., Makizako, H., Tsutsumimoto, K. et al. Association Between Insulin-Like Growth Factor-1 and Frailty Among Older Adults. J Nutr Health Aging 22, 68–72 (2018). https://doi.org/10.1007/s12603-017-0916-1

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  • DOI: https://doi.org/10.1007/s12603-017-0916-1

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