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Vitamin D status and the risk of recurrent stroke and mortality in ischemic stroke patients: Data from a 24-month follow-up study in China

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The journal of nutrition, health & aging

Abstract

Purpose

In this study, we determined serum 25-hydroxyvitamin D [25(OH) D] levels in serum, and investigated their associations with risk of recurrent stroke and mortality in a 24-month follow up study in Chinese patients with first-ever ischemic stroke.

Methods

In this preplanned post hoc analysis, serum levels of 25(OH) D and NIH stroke scale (NIHSS) were measured at the time of admission in a cohort of patients with ischemic stroke. We used logistic regression model to assess the relationship between 25(OH) D levels and risk recurrent stroke or mortality.

Results

The follow-up rate was 98.2% in 220 stroke patients. Of 216 patients, 18.5% (95%CI: 13.3%–23.7%) patients had a stroke recurrence, and 30.1% (95% CI: 24.0%–36.2%) died. After adjustment for traditional risk factors, serum 25(OH) D levels were negatively associated with the risk of stroke recurrence (odds ratio [OR], 0.77; 95% confidence interval [CI], 0.70–0.85; P< 0.001) and negatively associated with mortality during 24 months of follow-up (OR, 0.72; 95% CI, 0.64–0.80; P< 0.001). Compared with the first quartile of serum 25(OH) D levels, the ORs for stroke recurrence and mortality were as follows: second quartile, 0.80 (95% CI, 0.63–0.93) and 0.77 (95% CI, 0.65–0.89); third quartile, 0.42 (95% CI, 0.31–0.55) and 0.39 (95% CI, 0.30–0.52); fourth quartile, 0.12 (95% CI, 0.07–0.19) and 0.10 (95% CI, 0.06–0.15), respectively.

Conclusions

Lower serum levels of 25(OH) D are independently associated with the stroke recurrence and mortality at 24 months in ischemic stroke patients.

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Authors and Affiliations

  1. Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, No.6, Tiantanxili, Dongcheng District, Beijing, 100050, China

    H. Qiu, M. Wang & Jizong Zhao

  2. China National Clinical Research Center for Neurological Diseases, Beijing, 100050, China

    H. Qiu, M. Wang, D. Mi & Jizong Zhao

  3. Beijing Key Laboratory of Translation Medicine for Cerebrovascular Diseases, Beijing, 100050, China

    H. Qiu, M. Wang, D. Mi & Jizong Zhao

  4. Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, China

    D. Mi

  5. Institute of radiation medicine, Academy of Medical Science & Peking Union Medical College, Tianjin, 300192, China

    W. Tu & Q. Liu

  6. China Rehabilitation Research Center, Beijing, 100068, China

    W. Tu

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  1. H. Qiu
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  2. M. Wang
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  4. Jizong Zhao
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Correspondence to Jizong Zhao.

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Qiu, H., Wang, M., Mi, D. et al. Vitamin D status and the risk of recurrent stroke and mortality in ischemic stroke patients: Data from a 24-month follow-up study in China. J Nutr Health Aging 21, 766–771 (2017). https://doi.org/10.1007/s12603-016-0821-z

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  • DOI: https://doi.org/10.1007/s12603-016-0821-z

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