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Longitudinal systolic strain of the bilayered ventricular septum during the first 72 hours of life in preterm infants

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Abstract

Background

Quantitative evaluation of right ventricular myocardial performance in preterm infants remains a challenge because of the limitations of conventional echocardiographic measurement and the complex geometry of the right ventricle (RV). Serial assessment of peak longitudinal systolic strain on the right and left sides of the ventricular septum (VS), RV, and left ventricle (LV) during the transitional period in preterm infants using two-dimensional speckle-tracking echocardiography is reported.

Methods

In 21 preterm infants (33 ± 2 gestational weeks, 1,913 ± 218 g birth weight) without mechanical ventilation, inotropic agents, or symptomatic patent ductus arteriosus (PDA), longitudinal strain (LS) was measured on both sides of the VS, RV free wall, and LV, along with conventional echocardiography at 1, 3, 6, 9, 12, 24, 48, and 72 h after birth. Correlations and factors associated with echocardiographic measurements were analyzed.

Result

LS was maintained on the four analyzed regions during the first 72 h of life despite significant hemodynamic changes, including a decrease in pulmonary artery pressure and PDA closure. LS was significantly larger on the left side of the VS than on the right side of the VS at 1, 48, and 72 h after birth.

Conclusions

Preterm infants showed stable LS on both sides of the VS, the RV free wall, and the LV despite significant hemodynamic changes during the first 72 h of life. These results suggest that the right and left sides of the VS respond differently to the complex cardiopulmonary transitions from fetal to neonatal life in preterm infants.

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Acknowledgment

This study was approved by the institutional review board of Iwate Medical University (H25-63).

Conflict of interest

Yurie Nasu, Kotaro Oyama, Satoshi Nakano, Atsushi Matsumoto, Wataru Soda, Shin Takahashi, and Shoichi Chida declare that they have no conflict of interest.

Human rights statement and informed consent

All procedures followed were in accordance with the ethical standards of the institutional review board of Iwate Medical University and with the Helsinki Declaration of 1975, as revised in 2000. Informed consent was obtained from the parents of all subjects prior to enrolment.

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Authors and Affiliations

  1. Department of Pediatrics, Iwate Medical University School of Medicine, 19-1 Uchimaru, Morioka, Iwate, 020-8505, Japan

    Yurie Nasu, Kotaro Oyama, Satoshi Nakano, Atsushi Matsumoto, Wataru Soda, Shin Takahashi & Shoichi Chida

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  1. Yurie Nasu
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  2. Kotaro Oyama
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  3. Satoshi Nakano
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Correspondence to Yurie Nasu.

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Nasu, Y., Oyama, K., Nakano, S. et al. Longitudinal systolic strain of the bilayered ventricular septum during the first 72 hours of life in preterm infants . J Echocardiogr 13, 90–99 (2015). https://doi.org/10.1007/s12574-015-0250-8

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  • DOI: https://doi.org/10.1007/s12574-015-0250-8

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