Original Article

World Journal of Pediatrics

, Volume 5, Issue 2, pp 122-126

Pediatric reference intervals for soluble transferrin receptor and transferrin receptor-ferritin index

  • Cara Lianne OoiAffiliated withDepartment of Pediatrics, Children’s Hospital, London Health Science Centre, Schulich School of Medicine & Dentistry, University of Western Ontario
  • , Nathalie LepageAffiliated withDepartment of Pathology and Laboratory Medicine, Children’s Hospital of Eastern Ontario
  • , Ed NieuwenhuysAffiliated withSanquin Diagnostic Services
  • , Ajay Parkash SharmaAffiliated withDepartment of Pediatrics, Children’s Hospital, London Health Science Centre, Schulich School of Medicine & Dentistry, University of Western Ontario
  • , Guido FillerAffiliated withDepartment of Pediatrics, Children’s Hospital, London Health Science Centre, Schulich School of Medicine & Dentistry, University of Western Ontario Email author 

Rent the article at a discount

Rent now

* Final gross prices may vary according to local VAT.

Get Access

Abstract

Background

Recent studies showing an improved diagnosis of iron deficiency (ID) with soluble transferrin receptor (sTfR) and sTfR-ferritin index did not take into account the age-dependency of sTfR and ferritin. Moreover, there is a paucity of data on pediatric reference intervals for sTfR and sTfR-ferritin index.

Methods

A study cohort of 436 apparently healthy children was analyzed to establish reference intervals for ferritin, transferrin, sTfR and sTfR-ferritin index. To account for age-dependency, standard deviation scores (Z-scores) for these markers were calculated. The association between these parameters and C-reactive protein (CRP) was analyzed.

Results

The Z-scores of ferritin, transferrin and sTfR had a significant association with CRP, whereas the Z-score of sTfR-ferritin did not correlate with CRP. The reference intervals of these parameters were reported.

Conclusion

Among the different markers of ID, the Z-scores of sTfR, transferrin and ferritin, but not sTfR-ferritin index, associate with the inflammatory status.

Key words

C-reactive protein ferritin reference interval soluble transferrin receptor soluble transferrin receptor-ferritin index transferrin