Pediatric reference intervals for soluble transferrin receptor and transferrin receptor-ferritin index
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Recent studies showing an improved diagnosis of iron deficiency (ID) with soluble transferrin receptor (sTfR) and sTfR-ferritin index did not take into account the age-dependency of sTfR and ferritin. Moreover, there is a paucity of data on pediatric reference intervals for sTfR and sTfR-ferritin index.
A study cohort of 436 apparently healthy children was analyzed to establish reference intervals for ferritin, transferrin, sTfR and sTfR-ferritin index. To account for age-dependency, standard deviation scores (Z-scores) for these markers were calculated. The association between these parameters and C-reactive protein (CRP) was analyzed.
The Z-scores of ferritin, transferrin and sTfR had a significant association with CRP, whereas the Z-score of sTfR-ferritin did not correlate with CRP. The reference intervals of these parameters were reported.
Among the different markers of ID, the Z-scores of sTfR, transferrin and ferritin, but not sTfR-ferritin index, associate with the inflammatory status.
- Pediatric reference intervals for soluble transferrin receptor and transferrin receptor-ferritin index
World Journal of Pediatrics
Volume 5, Issue 2 , pp 122-126
- Cover Date
- Print ISSN
- Online ISSN
- SP Children’s Hospital, Zhejiang University School of Medicine
- Additional Links
- C-reactive protein
- reference interval
- soluble transferrin receptor
- soluble transferrin receptor-ferritin index
- Author Affiliations
- 1. Department of Pediatrics, Children’s Hospital, London Health Science Centre, Schulich School of Medicine & Dentistry, University of Western Ontario, 800 Commissioners Road East, London, Ontario, N6A 7W9, Canada
- 2. Department of Pathology and Laboratory Medicine, Children’s Hospital of Eastern Ontario, 401 Smyth Road, Ottawa, Canada, K1H 8L1
- 3. Sanquin Diagnostic Services, Amsterdam, The Netherlands