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Encapsulation of Functional Lipophilic Food and Drug Biocomponents

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Abstract

Lipophilic biocomponents pose a real challenge to food and drug researchers because they have weak solubility in water and cannot be easily included into the food and drug matrix. Biomaterials with new functional properties, i.e. biodegradable, biocompatible and stimulus responsive, have been tested for the purpose of improving the solubility and bioavailability of lipophilic components in recent years. Also, high-performance micro- and nanotechnologies were involved. These were used to prepare microcapsules and nanocarriers with multiple applications in food industry and pharmacy. The micro- and nano-encapsulation of lipophilic components is used to increase and maintain solubility in physiological fluids or the food matrix, to improve bioavailability and to protect the bioactive compounds against the aggression of some factors such as pH, enzymes, temperature, light and oxygen. The microcapsule and nanocarrier delivery systems guarantee the controlled and targeted delivery of bioactive molecules, thus increasing the therapeutic potential of drugs, along with food safety and security. The purpose of this review is to synthesize the newest information about the lipophilic biocomponents’ encapsulation. The first part of the paper is devoted to data on the solubility and bioavailability of lipophilic components used for food and drug formulations. The second part deals with the main methods of lipophilic compounds encapsulation, evincing the preparation of nanoparticles with applicability in the food and drug industry.

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Acknowledgments

Project COST FA 1001—The application of innovative fundamental food-structure-property relationships to the design of foods for health, wellness and pleasure. The work of Cristian Dima was supported by Project SOP HRD—PERFORM/159/1.5/S/138963.

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  1. Faculty of Sciences and Environment, 111 Domneasca St., 800201, Galaţi, Romania

    Ştefan Dima

  2. Faculty of Food Science and Engineering, 111 Domneasca St., 800201, Galaţi, Romania

    Cristian Dima & Gabriela Iordăchescu

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  1. Ştefan Dima
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  2. Cristian Dima
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Correspondence to Gabriela Iordăchescu.

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Dima, Ş., Dima, C. & Iordăchescu, G. Encapsulation of Functional Lipophilic Food and Drug Biocomponents. Food Eng Rev 7, 417–438 (2015). https://doi.org/10.1007/s12393-015-9115-1

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