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The high matrix acquisition technique for imaging of atherosclerotic plaque inflammation in fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography with time-of-flight: Phantom study

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Journal of Nuclear Cardiology Aims and scope

Abstract

Background

Motion artifact and partial volume effect caused underestimation of coronary plaque inflammation. This study evaluated the high matrix acquisition technique using time-of-flight (TOF) positron emission tomography/computed tomography for imaging of atherosclerotic plaque inflammation with fluorine-18 fluorodeoxyglucose in small and moving phantoms.

Methods and Results

All images were reconstructed using a conventional algorithm without TOF (4 × 4 × 4 mm3 voxel size) and a high matrix algorithm with TOF (2 × 2 × 2 mm3 voxel size). Microsphere phantoms of 10, 7.9, 6.2, 5.0, and 4.0 mm diameters were acquired in 3-dimensional list-mode for 30 minutes. A heart phantom mimicking cardiac motion consisted of a hot spot simulating a plaque (φ 4 mm, φ 2 mm) on the outside of the left ventricle. In the microsphere and heart phantom study, visual discrimination, maximum activity, and target-to-background ratio using the high matrix algorithm with TOF were better than those using the conventional algorithm without TOF.

Conclusion

The high matrix algorithm with TOF improves detection of small targets in phantoms.

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Abbreviations

18F-FDG:

Fluorine-18 fluorodeoxyglucose

SNR:

Signal-to-noise ratio

TOF:

Time-of-flight

PVE:

Partial volume effect

LOR:

Line of response

TBR:

Target-to-background ratio

ROI:

Region-of-interest

RC:

Recovery coefficient

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Disclosure

The authors have no conflict of interest to disclose with respect to this paper.

Author information

Authors and Affiliations

  1. Clinical Imaging Center for Healthcare, Nippon Medical School, 1-12-15, Sendagi, Bunkyo, Tokyo, 113-0022, Japan

    Masaya Suda PhD, Keiichi Ishihara MD & Minoru Sakurai BS

  2. Department of Radiology, Nippon Medical School, Tokyo, Japan

    Tomonari Kiriyama MD, Yasuhiro Kobayashi MD & Shin-ichiro Kumita MD

  3. Department of Quantum Medical Technology, Kanazawa University, Kanazawa, Japan

    Masahisa Onoguchi PhD & Takayuki Shibutani MHSc

Authors
  1. Masaya Suda PhD
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  2. Tomonari Kiriyama MD
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  3. Keiichi Ishihara MD
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  4. Masahisa Onoguchi PhD
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  5. Yasuhiro Kobayashi MD
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  6. Minoru Sakurai BS
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  7. Takayuki Shibutani MHSc
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  8. Shin-ichiro Kumita MD
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Corresponding author

Correspondence to Masaya Suda PhD.

Additional information

See related editorial, doi:10.1007/s12350-016-0549-5.

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Suda, M., Kiriyama, T., Ishihara, K. et al. The high matrix acquisition technique for imaging of atherosclerotic plaque inflammation in fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography with time-of-flight: Phantom study. J. Nucl. Cardiol. 24, 1161–1170 (2017). https://doi.org/10.1007/s12350-016-0510-7

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  • DOI: https://doi.org/10.1007/s12350-016-0510-7

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