Skip to main content
SpringerLink
Log in

Measurement of MBF by PET is ready for prime time as an integral part of clinical reports in diagnosis and risk assessment of patients with known or suspected CAD

For prime time not yet: Need impact and certainty

  • Debate Article
  • Published:
Journal of Nuclear Cardiology Aims and scope

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Schelbert HR. Anatomy and physiology of coronary blood flow. J Nucl Cardiol 2010;17:545-54.

    Article  PubMed  PubMed Central  Google Scholar 

  2. Herzog BA, Husmann L, Valenta I, Gaemperli O, Siegrist PT, Tay FM, et al. Long-term prognostic value of 13N-ammonia myocardial perfusion positron emission tomography added value of coronary flow reserve. J Am Coll Cardiol 2009;54:150-6. doi:10.1016/j.jacc.2009.02.069.

    Article  PubMed  Google Scholar 

  3. Fukushima K, Javadi MS, Higuchi T, Lautamaki R, Merrill J, Nekolla SG, et al. Prediction of short-term cardiovascular events using quantification of global myocardial flow reserve in patients referred for clinical 82Rb PET perfusion imaging. J Nucl Med 2011;52:726-32. doi:10.2967/jnumed.110.081828.

    Article  PubMed  Google Scholar 

  4. Murthy VL, Naya M, Foster CR, Hainer J, Gaber M, Di Carli G, et al. Improved cardiac risk assessment with noninvasive measures of coronary flow reserve. Circulation 2011;124:2215-24. doi:10.1161/CIRCULATIONAHA.111.050427.

    Article  PubMed  PubMed Central  Google Scholar 

  5. Ziadi MC, Dekemp RA, Williams KA, Guo A, Chow BJ, Renaud JM, et al. Impaired myocardial flow reserve on rubidium-82 positron emission tomography imaging predicts adverse outcomes in patients assessed for myocardial ischemia. J Am Coll Cardiol 2011;58:740-8. doi:10.1016/j.jacc.2011.01.065.

    Article  PubMed  Google Scholar 

  6. Hendel RC, Berman DS, Di Carli MF, Heidenreich PA, Henkin RE, Pellikka PA, et al. ACCF/ASNC/ACR/AHA/ASE/SCCT/SCMR/SNM 2009 appropriate use criteria for cardiac radionuclide imaging: A report of the American College of Cardiology Foundation Appropriate Use Criteria Task Force, the American Society of Nuclear Cardiology, the American College of Radiology, the American Heart Association, the American Society of Echocardiography, the Society of Cardiovascular Computed Tomography, the Society for Cardiovascular Magnetic Resonance, and the Society of Nuclear Medicine. J Am Coll Cardiol 2009;53:2201-29.

    Article  PubMed  Google Scholar 

  7. Taqueti VR, Hachamovitch R, Murthy VL, Naya M, Foster CR, Hainer J, et al. Global coronary flow reserve is associated with adverse cardiovascular events independently of luminal angiographic severity and modifies the effect of early revascularization. Circulation 2015;131:19-27. doi:10.1161/CIRCULATIONAHA.114.011939.

    Article  PubMed  Google Scholar 

  8. Bateman TM, Case JA. Variability in normal myocardial blood flow measurements: Physiologic, methodologic, or protocol related? J Nucl Cardiol 2015;22:85-8. doi:10.1007/s12350-014-0007-1.

    Article  PubMed  Google Scholar 

  9. Bateman TM, Lance Gould K, Di-Carli MF. Proceedings of the Cardiac PET Summit, 12 May 2014, Baltimore, MD: 3: Quantitation of myocardial blood flow. J Nucl Cardiol 2015;22:571-8. doi:10.1007/s12350-015-0127-2.

    Article  PubMed  Google Scholar 

  10. Senneff MJ, Geltman EM, Bergmann SR. Noninvasive delineation of the effects of moderate aging on myocardial perfusion. J Nucl Med 1991;32:2037-42.

    CAS  PubMed  Google Scholar 

  11. Czernin J, Muller P, Chan S, Brunken RC, Porenta G, Krivokapich J, et al. Influence of age and hemodynamics on myocardial blood flow and flow reserve. Circulation 1993;88:62-9.

    Article  CAS  PubMed  Google Scholar 

  12. Uren NG, Camici PG, Melin JA, Bol A, de Bruyne B, Radvan J, et al. Effect of aging on myocardial perfusion reserve. J Nucl Med 1995;36:2032-6.

    CAS  PubMed  Google Scholar 

  13. Sunderland JJ, Pan XB, Declerck J, Menda Y. Dependency of cardiac rubidium-82 imaging quantitative measures on age, gender, vascular territory, and software in a cardiovascular normal population. J Nucl Cardiol 2015;22:72-84. doi:10.1007/s12350-014-9920-6.

    Article  PubMed  Google Scholar 

  14. Ziadi MC, Dekemp RA, Williams K, Guo A, Renaud JM, Chow BJ, et al. Does quantification of myocardial flow reserve using rubidium-82 positron emission tomography facilitate detection of multivessel coronary artery disease? J Nucl Cardiol 2012;19:670-80. doi:10.1007/s12350-011-9506-5.

    Article  PubMed  Google Scholar 

  15. Kofoed KF, Czernin J, Johnson J, Kobashigawa J, Phelps ME, Laks H, et al. Effects of cardiac allograft vasculopathy on myocardial blood flow, vasodilatory capacity, and coronary vasomotion. Circulation 1997;95:600-6.

    Article  CAS  PubMed  Google Scholar 

  16. Tio RA, Dabeshlim A, Siebelink HM, de Sutter J, Hillege HL, Zeebregts CJ, et al. Comparison between the prognostic value of left ventricular function and myocardial perfusion reserve in patients with ischemic heart disease. J Nucl Med 2009;50:214-9.

    Article  PubMed  Google Scholar 

  17. Takashio S, Yamamuro M, Izumiya Y, Sugiyama S, Kojima S, Yamamoto E, et al. Coronary microvascular dysfunction and diastolic load correlate with cardiac troponin T release measured by a highly sensitive assay in patients with nonischemic heart failure. J Am Coll Cardiol 2013;62:632-40.

    Article  CAS  PubMed  Google Scholar 

  18. CMS. Decision memo for positron emission tomography (FDG) for solid tumors (CAG-00181R4).

  19. Hachamovitch R. Does ischemia burden in stable coronary artery disease effectively identify revascularization candidates? Ischemia burden in stable coronary artery disease effectively identifies revascularization candidates. Circ Cardiovasc Imaging 2015;8:discussion 8.

  20. Reynolds HR, Picard MH, Hochman JS. Does ischemia burden in stable coronary artery disease effectively identify revascularization candidates? Ischemia burden in stable coronary artery disease does not effectively identify revascularization candidates. Circ Cardiovasc Imaging 2015;8:discussion 9.

Download references

Author information

Authors and Affiliations

  1. Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, University of California at Los Angeles, 650 Charles E Young Drive South, Los Angeles, CA, 90095, USA

    Heinrich Schelbert MD, PhD

Authors
  1. Heinrich Schelbert MD, PhD
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Heinrich Schelbert MD, PhD.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Schelbert, H. Measurement of MBF by PET is ready for prime time as an integral part of clinical reports in diagnosis and risk assessment of patients with known or suspected CAD. J. Nucl. Cardiol. 25, 153–156 (2018). https://doi.org/10.1007/s12350-016-0423-5

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12350-016-0423-5

Keywords

Search

Navigation