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Quantitative and qualitative analysis and interpretation of CT perfusion imaging

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Journal of Nuclear Cardiology Aims and scope

Abstract

Coronary artery disease (CAD) remains the leading cause of death in the United States. Rest and stress myocardial perfusion imaging has an important role in the non-invasive risk stratification of patients with CAD. However, diagnostic accuracies have been limited, which has led to the development of several myocardial perfusion imaging techniques. Among them, myocardial computed tomography perfusion imaging (CTP) is especially interesting as it has the unique capability of providing anatomic- as well as coronary stenosis-related functional data when combined with computed tomography angiography (CTA). The primary aim of this article is to review the qualitative, semi-quantitative, and quantitative analysis approaches to CTP imaging. In doing so, we will describe the image data required for each analysis and discuss the advantages and disadvantages of each approach.

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Author information

Authors and Affiliations

  1. Division of Cardiology, Department of Medicine, Johns Hopkins University, 600 N. Wolfe Street, Carnegie Building 565C, Baltimore, MD, 21287, USA

    Carolina Valdiviezo MD, Marietta Ambrose MD, Vishal Mehra MD, Albert C. Lardo PhD, Joao A. C. Lima MD & Richard T. George MD

  2. Division of Nuclear Medicine, Russell Morgan Department of Radiology, Johns Hopkins University, Baltimore, MD, USA

    Joao A. C. Lima MD

  3. Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA

    Albert C. Lardo PhD

Authors
  1. Carolina Valdiviezo MD
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  2. Marietta Ambrose MD
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  3. Vishal Mehra MD
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  4. Albert C. Lardo PhD
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  5. Joao A. C. Lima MD
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  6. Richard T. George MD
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Corresponding author

Correspondence to Richard T. George MD.

Additional information

Drs George, Lima, and Lardo receive research funding from Toshiba Medical Systems. Drs George and Lima receive research funding and serve on the advisory board of Astellas Pharma US, Inc. The terms of these arrangements are managed by Johns Hopkins University in accordance with its conflict of interest policies.

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Valdiviezo, C., Ambrose, M., Mehra, V. et al. Quantitative and qualitative analysis and interpretation of CT perfusion imaging. J. Nucl. Cardiol. 17, 1091–1100 (2010). https://doi.org/10.1007/s12350-010-9291-6

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  • DOI: https://doi.org/10.1007/s12350-010-9291-6

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