Skip to main content
SpringerLink
Log in

Relationship between cord blood atherogenic index and birth weight in preeclampsia

  • Original Article
  • Published:
Mediterranean Journal of Nutrition and Metabolism

Abstract

The present study was designed to analyze cord blood atherogenic index (AI) in newborns of normal pregnant and preeclamptic subjects and to correlate them with birth weight and maternal AI. The study consisted of 50 healthy pregnant women (Group I: controls) and 50 women with preeclampsia. Ten milliliter cord blood was collected from placental end of umbilical cord and 5 ml of maternal venous sample was drawn from antecubital vein at the time of delivery. Serum was separated by centrifugation and Apo A-I and Apo B levels were analyzed by immunoturbidimetric Immunoassay kits. AI was calculated as ratio of Apo B to Apo A-I. Apo B levels were significantly elevated in Group II in both cord blood and maternal blood as compared to Group I (p < 0.001). Apo A-I levels were lower in maternal blood and higher in cord blood of group II. In maternal blood, AI was higher in Group II as compared to Group I (p < 0.001). In group I, a significant positive correlation was observed between cord blood AI and birth weight and values being higher in males. In group II, a significant negative correlation observed between cord blood AI and birth weight was higher in females.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

Similar content being viewed by others

References

  1. Stock MJ, Met Calfe J (1994) Maternal physiology during gestation. Raven Press, New York, pp 947–983

  2. Radunovic N, Kuczynski E, Rosen T (2000) Plasma apolipoprotein A-I and B concentrations in growth-retarded fetuses. A link between low birth weight and adult atherosclerosis. J Clin Endocrinol Metab 85:85–88

    Article  CAS  Google Scholar 

  3. McConathy WJ, Lane DM (1980) Studies on the apolipoproteins and lipoproteins in camel serum. Pediatr Res 14:757–761

    Article  CAS  Google Scholar 

  4. Barker DPJ, Marlyn CN, Osmond C, Hales CN, Fall CHD (1993) Growth in utero and serum cholesterol concentrations in adult life. Br Med J 307:1524–1527

    Article  CAS  Google Scholar 

  5. Yavuz T, Yavuz O, Oz demier I, Afsar Y (2006) Cord blood lipoprotein profile after magnesium sulfate treatment in preeclamptic patients. Acta Paediatr 95:1224–1227

    Article  Google Scholar 

  6. Labour C, Shepherd J, Rossewea M (1990) Immunological assays of apolipoproteins in plasma: methods and instrumentation. Clin Chem 36:561–567

    Google Scholar 

  7. Albers JJ, Marcovina SM, Kennedy H (1992) International federation of clinical chemistry and standardization projector measurement of apolipoproteins A-I and Apo B-II. Evaluation and selection, of candidate reference materials. Clin Chem 38:658–662

    CAS  Google Scholar 

  8. Dati F (1989) Estimation of apolipoproteins by immune-turbidimetric method. Lab Med 13:87–89

    Google Scholar 

  9. Belo L, Caslake M, Gaffney D, Santos SA, Peveira LL, Quintanihs A (2002) Changes in LDL size and HDL concentration in normal and preeclamptic pregnancies. Atherosclerosis 162:425–432

    Article  CAS  Google Scholar 

  10. Hubel CA, Lyall F, Weiss Feld I, Gandley RE, Roberts JM (1998) Small low density lipoprotein and vascular cell adhesion molecule-1 are increased in association with hyperlipidemia in preeclampsia. Metabolism 47:1281–1288

    Article  CAS  Google Scholar 

  11. Bayham G, Kocyigit Y, Atamer A, Atamer Y, Akkus Z (2005) Potential atherogenic role of lipids, lipoprotein (a) and lipid peroxidation in preeclampsia. Atherosclerosis 21:1–6

    Google Scholar 

  12. Wang J, Trudinger B (2000) Is an atherogenic lipoprotein profile in the fetus a prerequisite for placental vascular disease? BJOG 107:508–513

    Article  CAS  Google Scholar 

  13. Ortega RM, Gaspar MJ, Cantero M (1996) Influence of maternal serum lipids and maternal diet during the third trimester of pregnancy on umbilical cord blood lipids in two populations of Spanish newborns. Int J Vitam Nutr Res 66:250–257

    CAS  Google Scholar 

  14. Rodie VA, Caslake MJ, Stewart F, Satter M, Ramsay JE, Greer IA et al (2004) Fetal cord plasma lipoprotein status in uncomplicated human pregnancies and in pregnancies complicated by preeclampsia and intrauterine growth restriction. Atherosclerosis 176:181–187

    Article  CAS  Google Scholar 

  15. Kharb S, Kaur R, Singh V, Sangwan K (2010) Birth weight and cord blood lipoproteins and apolipoprotein levels in Indian new borns. Int J Prev Med 1:29–33

    Google Scholar 

  16. Kaur R, Singh V, Sangwan K, Kharb S (2007) Lipoprotein, apolipoprotein levels and thyroid function tests in cord blood and healthy young adults. In: Proceedings of 34th ABICON, New Delhi, December 2007

Download references

Conflict of interest

None.

Author information

Authors and Affiliations

  1. Department of Biochemistry, Pt. B.D. Sharma PGIMS, Rohtak, 124001, Haryana, India

    Simmi Kharb

  2. Department of Obstetrics and Gynecology, Pt. B.D. Sharma PGIMS, Rohtak, 124001, Haryana, India

    Smiti Nanda & Anudeep Batra

  3. H. No. 1447, Sector-I, Rohtak, 124001, Haryana, India

    Simmi Kharb

Authors
  1. Simmi Kharb
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Smiti Nanda
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Anudeep Batra
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Simmi Kharb.

About this article

Cite this article

Kharb, S., Nanda, S. & Batra, A. Relationship between cord blood atherogenic index and birth weight in preeclampsia. Mediterr J Nutr Metab 6, 59–61 (2013). https://doi.org/10.1007/s12349-012-0106-y

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12349-012-0106-y

Keywords

Search

Navigation