Abstract
There is no consensus guidelines for treating duodenal variceal bleeding, which is a rare and life-threatening complication of portal hypertension. Here we report an exceedingly unusual case in a 9-year-old boy who had developed left-sided portal hypertension after surgical treatment for pancreatoblastoma followed by a duodenal variceal bleeding with massive melena, severe anemia (hemoglobin 4.5 g/dL) and hypovolemic shock. Emergency partial splenic arterial embolization (PSE) provided a reduction of variceal bleeding and improved blood pressure. Endoscopic injection sclerotherapy (EIS) was subsequently performed and stopped the duodenal variceal bleeding without the complication of portal vein thrombosis caused by injected sclerosant under hepatopetal flow. Our case demonstrates that emergency combined therapy with PSE and EIS can be considered as the therapeutic option for the management of left-sided portal hypertension-induced ectopic variceal bleedings in order to avoid the complication of portal embolization by EIS and provide effective hematostasis.
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References
Köklü S, Coban S, Yüksel O, et al. Left-sided portal hypertension. Dig Dis Sci. 2007;52:1141–9.
Little AG, Moossa AR. Gastrointestinal hemorrhage from left-sided portal hypertension. An unappreciated complication of pancreatitis. Am J Surg. 1981;141:153–8.
Li ZY, Li B, Wu YL, et al. Acute pancreatitis associated left-sided portal hypertension with severe gastrointestinal bleeding treated by transcatheter splenic artery embolization: a case report and literature review. J Zhejiang Univ Sci B. 2013;14:549–54.
Manenti A. Splenic vein obstruction secondary to pancreatic carcinoma. Acta Chir Belg. 1981;80:245–8.
Köklü S, Yüksel O, Arhan M, et al. Report of 24 left-sided portal hypertension cases: a single-center prospective cohort study. Dig Dis Sci. 2005;50:976–82.
Zargar SA, Javid G, Khan BA, et al. Endoscopic ligation compared with sclerotherapy for bleeding esophageal varices in children with extrahepatic portal venous obstruction. Hepatology. 2002;36:666–72.
Rivet C, Robles-Medranda C, Dumortier J, et al. Endoscopic treatment of gastroesophageal varices in young infants with cyanoacrylate glue: a pilot study. Gastrointest Endosc. 2009;69:1034–8.
Stiegmann GV, Goff JS, Michaletz-Onody PA, et al. Endoscopic sclerotherapy as compared with endoscopic ligation for bleeding esophageal varices. N Engl J Med. 1992;326:1527–32.
Garcia-Tsao G, Bosch J. Management of varices and variceal hemorrhage in cirrhosis. N Engl J Med. 2010;362:823–32.
Gertsch P, Blumgart LH. Cure of a bleeding duodenal varix by sclerotherapy. Br J Surg. 1988;75:717.
Yeh YY, Hou MC, Lin HC, et al. Case report: successful obliteration of a bleeding duodenal varix using endoscopic ligation. J Gastroenterol Hepatol. 1998;13:591–3.
Kochar N, Tripathi D, McAvoy NC, et al. Bleeding ectopic varices in cirrhosis: the role of transjugular intrahepatic portosystemic stent shunts. Aliment Pharmacol Ther. 2008;28:294–303.
Norton ID, Andrews JC, Kamath PS. Management of ectopic varices. Hepatology. 1998;28(4):1154–8.
Tajiri T, Yoshida H, Obara K, et al. General rules for recording endoscopic findings of esophagogastric varices. Dig Endosc. 2010;22:1–9 (2nd edition).
Korula J, Yellin A, Kanel GC, et al. Portal vein thrombosis complicating endoscopic variceal sclerotherapy. Convincing further evidence. Dig Dis Sci. 1991;36:1164–7.
Watanabe N, Toyonaga A, Kojima S, et al. Current status of ectopic varices in Japan: results of a survey by the Japan society for portal hypertension. Hepatol Res. 2010;40:763–76.
Sonomura T, Horihata K, Yamahara K, et al. Ruptured duodenal varices successfully treated with balloon-occluded retrograde transvenous obliteration: usefulness of microcatheters. Am J Roentgenol. 2003;181:725–7.
Mitsunaga T, Yoshida H, Kouchi K, et al. Pediatric gastroesophageal varices: treatment strategy and long-term results. J Pediatr Surg. 2006;41:1980–3.
Ota K, Okazaki M, Higashihara H, et al. Combination of transileocolic vein obliteration and balloon-occluded retrograde transvenous obliteration is effective for ruptured duodenal varices. J Gastroenterol. 1999;34:694–9.
Ou HY, Huang TL, Chen TY, et al. Emergency splenic arterial embolization for massive variceal bleeding in liver recipient with left-sided portal hypertension. Liver Transpl. 2005;11:1136–9.
McDermott VG, England RE, Newman GE. Case report: bleeding gastric varices secondary to splenic vein thrombosis successfully treated by splenic artery embolization. Br J Radiol. 1995;68:928–30.
Meisheri IV, Kothari PR, Kumar A, et al. Splenic artery embolization for portal hypertension in children. Afr J Paediatr Surg. 2010;7:86–91.
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The authors declare that they have no conflict of interest.
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All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, as revised in 2008(5).
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Informed consent was obtained from the patient and their legal guardians to be included in the study.
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Sunakawa, H., Tokuhara, D., Yamamoto, A. et al. Successful emergency combined therapy with partial splenic arterial embolization and endoscopic injection therapy against a bleeding duodenal varix in a child. Clin J Gastroenterol 8, 138–142 (2015). https://doi.org/10.1007/s12328-015-0563-1
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DOI: https://doi.org/10.1007/s12328-015-0563-1