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Hypocalcemia secondary to hypomagnesemia in a patient with Crohn’s disease

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Abstract

A 42-year-old female with Crohn’s disease who had previously undergone multiple surgical interventions developed marked hypocalcemia, which could not be resolved with calcium administration. Markedly reduced serum magnesium levels were also observed. After intravenous magnesium administration, serum calcium levels rapidly normalized. In addition, the plasma levels of intact parathyroid hormone increased immediately after magnesium administration. These data strongly suggest that hypocalcemia resulted from disturbance of appropriate parathyroid hormone secretion caused by hypomagnesemia. After introduction of infliximab therapy, her abdominal symptoms and endoscopic findings improved, and serum calcium and magnesium levels stabilized within the normal range without magnesium administration.

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Disclosures

Conflict of Interest:

Akane Mukai, Shuji Yamamoto, and Kazuyoshi Matsumura declare that they have no conflict of interest.

Human/Animal Rights:

All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, as revised in 2008(5).

Informed Consent:

Informed consent was obtained from the patient for being included in the study.

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Authors and Affiliations

  1. Department of Gastroenterology, Shiga Medical Center for Adults, 5-4-30 Moriyama, Moriyama, Shiga, 524-8524, Japan

    Akane Mukai, Shuji Yamamoto & Kazuyoshi Matsumura

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  1. Akane Mukai
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  2. Shuji Yamamoto
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  3. Kazuyoshi Matsumura
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Correspondence to Shuji Yamamoto.

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Mukai, A., Yamamoto, S. & Matsumura, K. Hypocalcemia secondary to hypomagnesemia in a patient with Crohn’s disease. Clin J Gastroenterol 8, 22–25 (2015). https://doi.org/10.1007/s12328-014-0544-9

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  • DOI: https://doi.org/10.1007/s12328-014-0544-9

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