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How Phenotype Guides Management of the Most Common Malignant Salivary Neoplasms of the Larynx?

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Abstract

Salivary gland carcinomas of the larynx are uncommon. Adenoid cystic carcinoma is the most prevalent type of salivary gland carcinoma in this region, although other histologies such as mucoepidermoid carcinoma and adenocarcinomas have been reported. These tumors may present with advanced-stage due to nonspecific symptoms and their relatively slow-growing nature. The index of suspicion for a non-squamous cell carcinoma entity should be high when a submucosal mass is present. An accurate diagnosis is mandatory due to the impact each biologic entity has on treatment and outcome. Data concerning treatment and outcome are scarce, but primary surgery with utmost focus on free surgical margins is the treatment of choice. The role of adjuvant radiotherapy has not been well defined, although there is an agreement that it should be considered in advanced-stage or high-grade disease. This review considers only the most common malignant salivary neoplasms of the larynx with a focus on clinical management of these tumors.

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Acknowledgements

No funding or sponsorship was received for this study or publication of this article. All named authors meet the International Committee of Medical Journal Editors (ICMJE) criteria for authorship for this manuscript, take responsibility for the integrity of the work as a whole, and have given final approval for the version to be published. This article was written by members of the International Head and Neck Scientific Group (www.IHNSG.com).

Disclosures

Fernando López, Michelle D. Williams, Alena Skálová, Henrik Hellquist, Carlos Suárez, Iain J Nixon, Juan P Rodrigo, Antonio Cardesa, Primož Strojan, Miquel Quer, Jennifer L. Hunt, Alessandra Rinaldo, and Alfio Ferlito have nothing to disclose.

Compliance with Ethics Guidelines

This article is based on previously conducted studies and does not involve any new studies of human or animal subjects performed by any of the authors.

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Data sharing is not applicable to this article as no datasets were generated or analyzed during the current study.

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Authors and Affiliations

  1. Department of Otolaryngology, Hospital Universitario Central de Asturias, Oviedo, Spain

    Fernando López & Juan P. Rodrigo

  2. Instituto Universitario de Oncología del Principado de Asturias, Instituto de Investigación Sanitaria del Principado de Asturias and CIBERONC, ISCIII, University of Oviedo, Oviedo, Spain

    Fernando López, Carlos Suárez & Juan P. Rodrigo

  3. Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA

    Michelle D. Williams

  4. Department of Pathology, Faculty of Medicine in Plzen, Charles University in Prague, Plzen, Czech Republic

    Alena Skálová

  5. Department of Biomedical Sciences and Medicine, University of Algarve, Faro, Portugal

    Henrik Hellquist

  6. Departments of Surgery and Otolaryngology, Head and Neck Surgery, Edinburgh University, Edinburgh, UK

    Iain J. Nixon

  7. Department of Anatomic Pathology, Hospital Clinic, University of Barcelona, Barcelona, Spain

    Antonio Cardesa

  8. Department of Radiation Oncology, Institute of Oncology, Ljubljana, Slovenia

    Primož Strojan

  9. Department of Otolaryngology, Hospital Santa Creu i Sant Pau, Barcelona, Spain

    Miquel Quer

  10. Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR, USA

    Jennifer L. Hunt

  11. University of Udine School of Medicine, Udine, Italy

    Alessandra Rinaldo

  12. Coordinator of the International Head and Neck Scientific Group, Padua, Italy

    Alfio Ferlito

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  1. Fernando López
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Correspondence to Fernando López.

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López, F., Williams, M.D., Skálová, A. et al. How Phenotype Guides Management of the Most Common Malignant Salivary Neoplasms of the Larynx?. Adv Ther 34, 813–825 (2017). https://doi.org/10.1007/s12325-017-0494-y

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