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Constrained Spherical Deconvolution Tractography Reveals Cerebello-Mammillary Connections in Humans

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Abstract

According to the classical view, the cerebellum has long been confined to motor control physiology; however, it has now become evident that it exerts several non-somatic features other than the coordination of movement and is engaged also in the regulation of cognition and emotion. In a previous diffusion-weighted imaging-constrained spherical deconvolution (CSD) tractography study, we demonstrated the existence of a direct cerebellum-hippocampal pathway, thus reinforcing the hypothesis of the cerebellar role in non-motor domains. However, our understanding of limbic-cerebellar interconnectivity in humans is rather sparse, primarily due to the intrinsic limitation in the acquisition of in vivo tracing. Here, we provided tractographic evidences of connectivity patterns between the cerebellum and mammillary bodies by using whole-brain CSD tractography in 13 healthy subjects. We found both ipsilateral and contralateral connections between the mammillary bodies, cerebellar cortex, and dentate nucleus, in line with previous studies performed in rodents and primates. These pathways could improve our understanding of cerebellar role in several autonomic functions, visuospatial orientation, and memory and may shed new light on neurodegenerative diseases in which clinically relevant impairments in navigational skills or memory may become manifest at early stages.

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Acknowledgments

We thank Prof. Placido Bramanti, Science Manager of I.R.C.C.S. “Centro Neurolesi,” Messina, where the research was carried out.

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Authors and Affiliations

  1. Department of Biomedical, Dental Sciences and Morphological and Functional Images, University of Messina, 98125, Messina, Italy

    Alberto Cacciola, Demetrio Milardi, Pietro Ciolli, Daniele Bruschetta, Antonio Duca, Fabio Trimarchi, Angelo Quartarone & Giuseppe Anastasi

  2. IRCCS Centro Neurolesi “Bonino Pulejo”, S.S. 113, Via Palermo, C.da Casazza, 98124, Messina, Italy

    Demetrio Milardi, Lilla Bonanno, Silvia Marino, Margherita Russo & Angelo Quartarone

  3. Department of Clinical and Experimental Medicine, University of Messina, 98125, Messina, Italy

    Alessandro Calamuneri

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  1. Alberto Cacciola
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Cacciola, A., Milardi, D., Calamuneri, A. et al. Constrained Spherical Deconvolution Tractography Reveals Cerebello-Mammillary Connections in Humans. Cerebellum 16, 483–495 (2017). https://doi.org/10.1007/s12311-016-0830-9

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