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The Appraisement of Antioxidant and Oxidant Status in Women Undergoing Surgical Menopause

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Abstract

The present study was undertaken to study the impact of surgical menopause on oxidant and antioxidant status in relation to estrogen levels after 3 months of surgery. Total 130 women who had undergone total hysterectomy (TH) with or without bilateral salpingo-oophorectomy (BSO) were included in this study. The oxidant status was assessed by measuring plasma levels of malondialdehyde and antioxidant status was assessed by measuring superoxide dismutase, catalase, glutathione, glutathione peroxidase, estrogen, and Vitamin A, E and C levels. The malondialdehyde level was significantly increased (p < 0.05) in all women who underwent TH with or without BSO. Significant increased levels of superoxide dismutase were observed in women who underwent TH with BSO. The blood glutathione levels were significantly decreased in women after TH only but significantly increased in women who had undergone TH with BSO. The levels of estrogen, vitamin E and vitamin C were significantly decreased in women who underwent TH with BSO. The catalase, GPx and vitamin A did not differ significantly in all groups. The result suggests that surgical menopause is associated with oxidative stress which reiterates the fact that ovaries retain some function even after menopause.

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Acknowledgments

The authors wish to acknowledge Council of Scientific and Industrial Research, New Delhi for funding the study vide letter no: 27(0200)/09/EMR-II and Professor and Head, Department of Obstetrics and Gynaecology, Government Medical College and Hospital, Sector-32, Chandigarh for helping in successful completion of the project.

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Authors and Affiliations

  1. Department of Biotechnology, GGDSD College, Sec32-C, Chandigarh, India

    Avneet Kaur

  2. Genetic Centre, Government Medical College and Hospital, Sector-32, Chandigarh, 160031, India

    Pooja Negi & Gurjit Kaur

  3. Department of Obstetrics and Gynaecology, Government Multi Specialty Hospital, Sector-16, Chandigarh, India

    Veena Sarna

  4. Department of Biochemistry, Post Graduate Institute of Medical Education and Research, Sector-12, Chandigarh, India

    Rajendra Prasad

  5. Department of Psychiatry, Government Medical College and Hospital, Sector-32, Chandigarh, India

    Bir S. Chavan

  6. Department of Physiology, Government Medical College and Hospital, Sector-32, Chandigarh, India

    Anita Malhotra & Gurjit Kaur

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  1. Avneet Kaur
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Correspondence to Gurjit Kaur.

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Kaur, A., Negi, P., Sarna, V. et al. The Appraisement of Antioxidant and Oxidant Status in Women Undergoing Surgical Menopause. Ind J Clin Biochem 32, 179–185 (2017). https://doi.org/10.1007/s12291-016-0591-8

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  • DOI: https://doi.org/10.1007/s12291-016-0591-8

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