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Outcome of Cyclosporine Monotherapy in Patients of Aplastic Anemia: Experience of a Tertiary Care Hospital in Eastern India

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Abstract

Introduction

Immune suppression is a crucial pillar for treatment of aplastic anemia. Cyclosporine monotherapy is an easily available, affordable therapeutic option with good safety profile.

Methods and Materials

This prospective study was conducted over a period of 2 years from June 2012 to July 2014. The diagnosis and response to treatment of aplastic anemia was established as per published criteria. Follow up was done at 3 and 6 months in order to assess the response.

Results

57 patients of acquired aplastic anemia with median age of 37 years (6 to 81 years) were included in the study. 35 (62 %) cases were severe aplastic anemai, 16 (28 %) non severe aplastic anemia and 6 (10 %) were very severe aplastic anemia. At 3 months overall response rate (OR) was 7 (14 %) and at 6 months the OR rate of 11 (19.6 %) was achieved. Transiently raised creatinine, liver function abnormality and gum hypertrophy were the main side effects observed in this cohort.

Conclusion

Oral cyclosporine monotherapy at dose of 5 mg/kg/day is a relatively safe treatment option for resource poor patients with aplastic anemia.

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Authors Contribution

Contributor

Concept

Study design

Data collection

Statistical analysis

Literature overview

Discussion

Fund generation

Prakas Kumar Mandal

Yes

Yes

Yes

Yes

Yes

Yes

Nil

Suvraneel Baul

Yes

Yes

Yes

Yes

Yes

Yes

Nil

Tuphan Kanti Dolai

Yes

Yes

–

–

–

Yes

Nil

Rajib De

Yes

Yes

–

–

–

Yes

Nil

Prantar Chakrabarti

Yes

Yes

–

–

Yes

Yes

Nil

Author information

Authors and Affiliations

  1. Department of Hematology, Nilratan Sircar Medical College, 8C/1/N, Roy Para Road, Kolkata, WB, 700050, India

    Prakas Kumar Mandal, Suvraneel Baul, Tuphan Kanti Dolai, Rajib De & Prantar Chakrabarti

Authors
  1. Prakas Kumar Mandal
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  2. Suvraneel Baul
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  3. Tuphan Kanti Dolai
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  4. Rajib De
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  5. Prantar Chakrabarti
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Corresponding author

Correspondence to Prakas Kumar Mandal.

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Conflict of interest

The authors have declared no competing interests.

Informed Consent

Informed consent was obtained from all individual participants included in the study.

Ethical Approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional research committee.

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Mandal, P.K., Baul, S., Dolai, T.K. et al. Outcome of Cyclosporine Monotherapy in Patients of Aplastic Anemia: Experience of a Tertiary Care Hospital in Eastern India. Indian J Hematol Blood Transfus 33, 144–147 (2017). https://doi.org/10.1007/s12288-016-0706-7

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  • DOI: https://doi.org/10.1007/s12288-016-0706-7

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