Skip to main content
SpringerLink
Log in

Celiac Disease with Pure Red Cell Aplasia: An Unusual Hematologic Association in Pediatric Age Group

  • Case Report
  • Published:
Indian Journal of Hematology and Blood Transfusion Aims and scope Submit manuscript

Abstract

Anemia in Celiac disease (CD) is usually hypoproliferative, reflecting impaired absorption of essential nutrients like iron and various vitamins. We report a 2-year-old boy with Celiac disease and severe anemia due to pure red cell aplasia, diagnosed by bone marrow biopsy. This rare, unexplained extra digestive manifestation responded to gluten free diet.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

References

  1. Husby S, Koletzko S, Korponay-Szabo´ IR et al (2012) European Society for Pediatric Gastroenterology, Hepatology, and Nutrition Guidelines for the Diagnosis of Coeliac Disease. J Pediatr Gastroenterol Nutr 54:136–160

    Article  PubMed  CAS  Google Scholar 

  2. Tack GJ, Verbeek WHM, Schreurs MWJ, Mulder CJJ (2010) The spectrum of celiac disease: epidemiology, clinical aspects and treatment. Nature Rev Gastroenterol Hepatol 7:204–213

    Article  CAS  Google Scholar 

  3. Halfdanarson TR, Litzow MR, Murray JA (2007) Hematological manifestations of celiac disease. Blood 109(2):412–421

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  4. Nara N (2002) Pure red cell aplasia as an autoimmune-mediated disorder. Intern Med 41(7):507–508

    Article  PubMed  Google Scholar 

  5. Mandal AK, Mehdi I, Munshi SK, Lo TC (2004) Value of routine duodenal biopsy in diagnosing coeliac disease in patients with iron deficiency anaemia. Postgrad Med J 80:475–477

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  6. Couderc AL, Costello R, Bagnères D et al (2006) Is pure red cell aplasia a new extra digestive manifestation of celiac disease? Rev Med Intern 27(4):336–339

    Article  Google Scholar 

  7. Casadevall N, Dupuy E, Molho-Sabatier P et al (1996) Autoantibodies against erythropoietin in a patient with pure red-cell aplasia. N Engl J Med 334:630–633

    Article  PubMed  CAS  Google Scholar 

  8. Handgretinger R, Geiselhart A, Moris A et al (1999) Pure red-cell aplasia associated with clonal expansion of granular lymphocytes expressing killer-cell inhibitory receptors. N Engl J Med 340:278–284

    Article  PubMed  CAS  Google Scholar 

  9. Maiuri L, Ciacci C, Ricciardelli I et al (2003) Association between innate response to gliadin and activation of pathogenic T cells in celiac disease. Lancet 362(9377):30–37

    Article  PubMed  CAS  Google Scholar 

  10. Hue S, Mention JJ, Monteiro RC et al (2004) A direct role for NKG2D/MICA interaction in villous atrophy during celiac disease. Immunity 21(3):367–377

    Article  PubMed  Google Scholar 

  11. Tang F, Chen Z, Ciszewski C et al (2009) Cytosolic PLA2 is required for CTL-mediated immunopathology of celiac disease via NKG2D and IL-15. J Exp Med 206(3):707–719

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  12. Harper JW, Holleran SF, Ramakrishnan R, Bhagat G, Green PHR (2007) Anemia in celiac disease is multifactorial in etiology. Am J Hematol 82(11):996–1000

    Article  PubMed  Google Scholar 

  13. Scott BB, Losowsky MS (1975) Coeliac disease: a cause of various associated diseases? Lancet 2(7942):956–957

    Article  PubMed  CAS  Google Scholar 

  14. Denham Jolanda M, Hill Ivor D (2013) Celiac Disease and Autoimmunity: review and controversies. Curr Allergy Asthma Rep 13:347–353

    Article  PubMed  CAS  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pediatrics, Medical College Hospital, Govt. Housing Estate, Block-B, Flat-6, 82 Belgachia Road, Kolkata, 700037, West Bengal, India

    Sitangshu Chatterjee, Pranab Kumar Dey, Pratyay Roy & Malay Kumar Sinha

Authors
  1. Sitangshu Chatterjee
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Pranab Kumar Dey
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Pratyay Roy
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Malay Kumar Sinha
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Pranab Kumar Dey.

Electronic supplementary material

Below is the link to the electronic supplementary material.

(JPEG 1060 kb)

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Chatterjee, S., Dey, P.K., Roy, P. et al. Celiac Disease with Pure Red Cell Aplasia: An Unusual Hematologic Association in Pediatric Age Group. Indian J Hematol Blood Transfus 30 (Suppl 1), 383–385 (2014). https://doi.org/10.1007/s12288-014-0425-x

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12288-014-0425-x

Keywords

Search

Navigation