Zusammenfassung
Läsionen des N. lingualis oder N. alveolaris inferior, die keine Aussicht auf eine Spontanregeneration und Wiederherstellung der sensiblen Restitution besitzen, kommen im Rahmen von Tumorresektionen, Traumen und akzidentell bei dentoalveolären oder orthognath-chirurgischen Eingriffen vor. Bei geschlossenen Nervenverletzungen ist die klinische Differenzierung einer irreversiblen Läsion und somit die Indikationsstellung zur operativen Reparatur oder Rekonstruktion nur durch Verlaufsbeobachtung möglich. Ein frühzeitiges Timing bis zur Wiederherstellungsoperation gilt als kritisch für die funktionelle neurosensorische Restitution. Der Frage, welche Größenordnung dem optimalen Zeitfenster zugemessen werden sollte, wird in einer Literaturübersicht des letzten Jahrzehnts nachgegangen. Nach Darstellung der heute verfügbaren mikroneuralen Operationstechniken werden unter Berücksichtigung der derzeitigen Datenlage Überlegungen und Wege zur Entscheidungsfindung sowie zur Operationsindikationsstellung in verschiedenen Verletzungsszenarien vorgestellt.
Abstract
Injuries of the lingual nerve (LN) or the inferior alveolar nerve (IAN) which do not have the potential for spontaneous regeneration and sensory restitution are the typical sequelae of oral cancer resection, traumatic avulsion and accidental injuries resulting from dentoalveolar or orthognathic surgical procedures. In closed injuries the irreversible nature of a lesion and the necessity to operate can be revealed only expectantly by clinical assessment of neurosensory function during a regular follow-up. A short term microneural intervention is regarded crucial for functional sensory recovery. The appropriate time slot for surgery however continues to be a controversial topic and is figured out on findings from the recent literature. After an introductory review of currently available microneural surgical techniques some thoughts and road maps for decision making as well as up to date indications for surgery related to different injury scenarios are addressed with respect to the latest data.
Literatur
Ahlgren FK, Johannessen AC, Hellem S (2003) Displaced calcium hydroxide paste causing inferior alveolar nerve paraesthesia: report of a case. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 96:734–737
Ahonen M, Tjaderhane L (2011) Endodontic-related paresthesia: a case report and literature review. J Endod 37:1460–1464
Al-Bishri A, Rosenquist J, Sunzel B (2004) On neurosensory disturbance after sagittal split osteotomy. J Oral Maxillofac Surg 62:1472–1476
AxoGen Inc. (2011) Avance nerve graft: the natural connection. http://www.Axogeninc.com
Bagheri SC, Meyer RA, Khan HA, Steed MB (2009) Microsurgical repair of peripheral trigeminal nerve injuries from maxillofacial trauma. J Oral Maxillofac Surg 67:1791–1799
Bagheri SC, Meyer RA, Cho S et al (2010) A retrospective review of microsurgical repair of 186 inferior alveolar nerve injuries. J Oral Maxillofac Surg 68(Suppl 1):e27
Bagheri SC, Meyer RA, Khan HA et al (2010) Retrospective review of microsurgical repair of 222 lingual nerve injuries. J Oral Maxillofac Surg 68:715–723
Bagheri SC, Meyer RA, Khan HA et al (2010) Microsurgical repair of the peripheral trigeminal nerve after mandibular sagittal split ramus osteotomy. J Oral Maxillofac Surg 68:2770–2782
Bagheri SC, Meyer RA (2011) Management of mandibular nerve injuries from dental implants. Atlas Oral Maxillofac Surg Clin North Am 19:47–61
Bagheri SC, Meyer RA, Cho SH et al (2012) Microsurgical repair of the inferior alveolar nerve: success rate and factors that adversely affect outcome. J Oral Maxillofac Surg 70:1978–1990
Battiston B, Tos P, Cushway TR, Geuna S (2000) Nerve repair by means of vein filled with muscle grafts I. Clinical results. Microsurgery 20:32–36
Bede SY, Ismael WK, Al-Assaf DA, Omer SS (2012) Inferior alveolar nerve injuries associated with mandibular fractures. J Craniofac Surg 23:1776–1778
Benito-Ruiz J, Navarro-Monzonis A, Piqueras A, Baena-Montilla P (1994) Invaginated vein graft as nerve conduit: an experimental study. Microsurgery 15:105–115
Boliek CA, Rieger JM, Li SY et al (2007) Establishing a reliable protocol to measure tongue sensation. J Oral Rehabil 34:433–441
Brooks DN, Weber RV, Chao JD et al (2012) Processed nerve allografts for peripheral nerve reconstruction: a multicenter study of utilization and outcomes in sensory, mixed, and motor nerve reconstructions. Microsurgery 32:1–14
Brushart TM (2011) Nerve repair. Oxford University Press, Oxford
Chang YM, Rodriguez ED, Chu YM et al (2012) Inferior alveolar nerve reconstruction with interpositional sural nerve graft: a sensible addition to one-stage mandibular reconstruction. J Plast Reconstr Aesthet Surg 65:757–762
Chiu DT, Strauch B (1990) A prospective clinical evaluation of autogenous vein grafts used as a nerve conduit for distal sensory nerve defects of 3 cm or less. Plast Reconstr Surg 86:928–934
Cornelius CP, Roser M, Ehrenfeld M (1997) Mikroneurale Wiederherstellung nach iatrogenen Lasionen des N. lingualis und des N. alveolaris inferior. Kritische Bestandsaufnahme. Mund Kiefer Gesichtschir 1:213–223
Cornelius CP, Born A, Wiethölter H, Wolburg H (2002) Vein conduits with intraluminal matrix materials for peripheral nerve repair in comparison to autogenous nerve grafting. Experimental findings. J Craniomaxillofac Surg 30(Suppl 1):232
Dellon AL, Andonian E, DeJesus RA (2007) Measuring sensibility of the trigeminal nerve. Plast Reconstr Surg 120:1546–1550
Donoff RB (1995) Surgical management of inferior alveolar nerve injuries (Part I): the case for early repair. J Oral Maxillofac Surg 53:1327–1329
Elfring TT, Boliek CA, Seikaly H et al (2012) Sensory outcomes of the anterior tongue after lingual nerve repair in oropharyngeal cancer. J Oral Rehabil 39:170–181
Erakat MS, Chuang SK, Shanti RM, Ziccardi VB (2013) Interval between injury and lingual nerve repair as a prognostic factor for success using type I collagen conduit. J Oral Maxillofac Surg 71:833–838
Fagin AP, Susarla SM, Donoff RB et al (2012) What factors are associated with functional sensory recovery following lingual nerve repair? J Oral Maxillofac Surg 70:2907–2915
Farole A, Jamal BT (2008) A bioabsorbable collagen nerve cuff (NeuraGen) for repair of lingual and inferior alveolar nerve injuries: a case series. J Oral Maxillofac Surg 66:2058–2062
Gennaro P, Gabriele G, Della Monaca M et al (2012) Mandibular nerve fascicular cross-face for sensitive recovery after mandibulectomy: a new technique. J Plast Surg Hand Surg (Epub ahead of print 13 June 2012)
Gregg JM (1995) Surgical management of inferior alveolar nerve injuries (part II): the case for delayed management. J Oral Maxillofac Surg 53:1330–1333
Grötz KA, Al-Nawas B, Aguiar EG de et al (1998) Treatment of injuries to the inferior alveolar nerve after endodontic procedures. Clin Oral Investig 2:73–76
Hadlock TA, Sundback CA, Hunter DA et al (2001) A new artificial nerve graft containing rolled Schwann cell monolayers. Microsurgery 21:96–101
Hausamen JE, Samii M, Schmidseder R (1973) Repair of the mandibular nerve by means of autologous nerve grafting after\resection of the lower jaw. J Maxillofac Surg 1:74–78
Hausamen JE, Schmelzeisen R (1996) Current principles in microsurgical nerve repair. Br J Oral Maxillofac Surg 34:143–157
Hayashi A, Yanai A, Komuro Y et al (2004) Collateral sprouting occurs following end-to-side neurorrhaphy. Plast Reconstr Surg 114:129–137
Hillerup S, Stoltze K (2007) Lingual nerve injury II. Observations on sensory recovery after micro-neurosurgical reconstruction. Int J Oral Maxillofac Surg 36:1139–1145
Hölzle F, Riediger D, Ehrenfeld M (2012) Mikronervenchirurgie. In: Hausamen JE, Machtens E, Reuther J et al (Hrsg) Mund-, Kiefer- und Gesichtschirurgie – Operationslehre und -atlas, Kap. 23. 4. Aufl. Springer, Berlin Heidelberg New York Tokio, S 709–724
Jones RH (2010) The use of vein grafts in the repair of the inferior alveolar nerve following surgery. Aust Dent J 55:207–213
Juodzbalys G, Wang HL, Sabalys G et al (2013) Inferior alveolar nerve injury associated with implant surgery. Clin Oral Implants Res 24:183–190
Kaban LB, Upton J (1986) Cross mental nerve graft for restoration of lip sensation after inferior alveolar nerve damage: report of case. J Oral Maxillofac Surg 44:649–651
Kay SP, Wiberg M, Thornton DJ (2010) Nerves are living structures whose injury requires urgent repair. J Plast Reconstr Aesthet Surg 63:1939–1940
Kehoe S, Zhang XF, Boyd D (2012) FDA approved guidance conduits and wraps for peripheral nerve injury: a review of materials and efficacy. Injury 43:553–572
Kelleher MO, Al-Abri RK, Eleuterio ML et al (2001) The use of conventional and invaginated autologous vein grafts for nerve repair by means of entubulation. Br J Plast Surg 54:53–57
Khawaja N, Renton T (2009) Case studies on implant removal influencing the resolution of inferior alveolar nerve injury. Br Dent J 206(7):365–370. DOI 10.1038/sj.bdj.2009.258
Kim JH, Rho YS, Ahn HY, Chung CH (2008) Comparison of sensory recovery and morphologic change between sensate and nonsensate flaps in oral cavity and oropharyngeal reconstruction. Head Neck 30:1099–1104
LaBanc JP, Epker BN, Jones DL, Milam S (1987) Nerve sharing by an interpositional sural nerve graft between the great auricular and inferior alveolar nerve to restore lower lip sensation. J Oral Maxillofac Surg 45:621–627
Lopez-Lopez J, Estrugo-Devesa A, Jane-Salas E, Segura-Egea JJ (2012) Inferior alveolar nerve injury resulting from overextension of an endodontic sealer: non-surgical management using the GABA analogue pregabalin. Int Endod J 45:98–104
Lundborg G (2004) Nerve injury and repair, regeneration, reconstruction and cortical remodeling. 2. Aufl. Elsevier, Philadelphia
Mackinnon S, Dellon AL (1988) Surgery of the peripheral nerve. Thieme, New York
Mackinnon SE, Dellon AL (1990) Clinical nerve reconstruction with a bioabsorbable polyglycolic acid tube. Plast Reconstr Surg 85:419–424
Meek MF, Coert JH (2008) US Food and Drug Administration/Conformit Europe-approved absorbable nerve conduits for clinical repair of peripheral and cranial nerves. Ann Plast Surg 60:110–116
Meyer RA, Bagheri SC (2013) Microsurgical reconstruction of the trigeminal nerve. Oral Maxillofac Surg Clin North Am 25:287–302
Meyer RA, Bagheri SC (2013) Clinical evaluation of nerve injuries. In: Miloro M (Hrsg) Trigeminal nerve injuries, Kap. 10. Springer, Berlin Heidelberg New York Tokio, S 167–198
Millesi H (2000) Techniques for nerve grafting. Hand Clin16:73–91, viii
Miyamoto Y (1979) Experimental study of results of nerve suture under tension vs. nerve grafting. Plast Reconstr Surg 64:540–549
Mundinger GS, Prucz RB, Rozen SM, Tufaro AP (2012) Reconstruction of the inferior alveolar nerve with bioabsorbable polyglycolic acid nerve conduits. Plast Reconstr Surg 129:110e–117e
Nijhuis TH, Bodar CW, Neck JW van et al (2013) Natural conduits for bridging a 15-mm nerve defect: comparison of the vein supported by muscle and bone marrow stromal cells with a nerve autograft. J Plast Reconstr Aesthet Surg 66:251–259
O’Connell DA, Reiger J, Dziegielewski PT et al (2009) Effect of lingual and hypoglossal nerve reconstruction on swallowing function in head and neck surgery: prospective functional outcomes study. J Otolaryngol Head Neck Surg 38:246–254
Pogrel MA, Maghen A (2001) The use of autogenous vein grafts for inferior alveolar and lingual nerve reconstruction. J Oral Maxillofac Surg 59:985–988, discussion: 988–993
Pogrel MA (2002) The results of microneurosurgery of the inferior alveolar and lingual nerve. J Oral Maxillofac Surg 60:485–489
Riedl O, Frey M (2013) Anatomy of the sural nerve: cadaver study and literature review. Plast Reconstr Surg 131:802–810
Risitano G, Cavallaro G, Merrino T et al (2002) Clinical results and thoughts on sensory nerve repair by autologous vein graft in emergency hand reconstruction. Chir Main 21:194–197
Robinson P, Smith KG (1996) A study on the efficacy of late lingual nerve repair. J Oral Maxillofac Surg 34:96–103
Robinson PP, Loescher AR, Smith KG (2000) A prospective, quantitative study on the clinical outcome of lingual nerve repair. Br J Oral Maxillofac Surg 38:255–263
Robinson PP, Loescher AR, Yates JM, Smith KG (2004) Current management of damage to the inferior alveolar and lingual nerves as a result of removal of third molars. Br J Oral Maxillofac Surg 42:285–292
Rodrigues MC, Rodrigues AA Jr, Glover LE et al (2012) Peripheral nerve repair with cultured Schwann cells: getting closer to the clinics. Sci World J: Article ID 413091
Rutner TW, Ziccardi VB, Janal MN (2005) Long-term outcome assessment for lingual nerve microsurgery. J Oral Maxillofac Surg 63:1145–1149
Schmelzle R (1985) Ergebnisse der chirurgischen Therapie der Verletzungen der Nn. alveolaris inferior, lingualis und facialis. Fortschr Kiefer Gesichtschir 30:59–61
Schultze-Mosgau S, Erbe M, Rudolph D et al (1999) Prospective study on post-traumatic and postoperative sensory disturbances of the inferior alveolar nerve and infraorbital nerve in mandibular and midfacial fractures. J Craniomaxillofac Surg 27:86–93
Scrivani SJ, Moses M, Donoff RB, Kaban LB (2000) Taste perception after lingual nerve repair. J Oral Maxillofac Surg 58:3–5, discussion:5–6
Seo K, Inada Y, Terumitsu M et al (2013) Protracted delay in taste sensation recovery after surgical lingual nerve repair: a case report. J Med Case Rep 7:77
Shanti RM, Viccardi VB (2011) Use of decellularized nerve allograft for inferior alveolar nerve reconstruction. J Oral Maxillofac Surg 69:550–553
Strauch B, Ferder M, Lovelle-Allen S et al (1996) Determining the maximal length of a vein conduit used as an interposition graft for nerve regeneration. J Reconstr Microsurg 12:521–527
Strauch B, Rodriguez DM, Diaz J et al (2001) Autologous Schwann cells drive regeneration through a 6-cm autogenous venous nerve conduit. J Reconstr Microsurg 17:589–595, discussion: 586–587
Strauss ER, Ziccardi VB, Janal MN (2006) Outcome assessment of inferior alveolar nerve microsurgery: a retrospective review. J Oral Maxillofac Surg 64:1767–1770
Sulaiman W, Gordon T (2013) Neurobiology of peripheral nerve injury, regeneration, and functional recovery: from bench top research to bedside application. Ochsner J 13:100–108
Susarla SM, Lam NP, Donoff RB et al (2005) A comparison of patient satisfaction and objective assessment of neurosensory function after trigeminal nerve repair. J Oral Maxillofac Surg 63:1138–1144
Susarla SM, Kaban LB, Donoff RB, Dodson TB (2007) Functional sensory recovery after trigeminal nerve repair. J Oral Maxillofac Surg 65:60–65
Susarla SM, Kaban LB, Donoff RB, Dodson TB (2007) Does early repair of lingual nerve injuries improve functional sensory recovery? J Oral Maxillofac Surg 65:1070–1076
Tang JB (1995) Vein conduits with interposition of nerve tissue for peripheral nerve defects. J Reconstr Microsurg 11:21–26
Tay AB, Poon CY, Teh LY (2008) Immediate repair of transected inferior alveolar nerves in sagittal split osteotomies. J Oral Maxillofac Surg 66:2476–2481
Terzis J, Faibisoff B, Williams H (1975) The nerve gap: suture under tension vs. graft. Plast Reconstr Surg 56:166–170
Thurmüller P, Dodson TB, Kaban LB (2001) Nerve injuries associated with facial trauma: natural history, management, and outcomes of repair. Oral Maxillofac Surg Clin North Am 13:283–293
Tos P, Battiston B, Ciclamini D et al (2012) Primary repair of crush nerve injuries by means of biological tubulization with muscle-vein-combined grafts. Microsurgery 32:358–363
Urken ML, Weinberg H, Vickery C, Biller HF (1990) The neurofasciocutaneous radial forearm flap in head and neck reconstruction: a preliminary report. Laryngoscope 100:161–173
Weber RA, Breidenbach WC, Brown RE et al (2000) A randomized prospective study of polyglycolic acid conduits for digital nerve reconstruction in humans. Plast Reconstr Surg 106:1036–1045
Wessberg GA, Wolford LM, Epker BN (1982) Simultaneous inferior alveolar nerve graft and osseous reconstruction of the mandible. J Oral Maxillofac Surg 40:384–390
Westermark A, Bystedt H, Konow L von (1998) Inferior alveolar nerve function after mandibular osteotomies. Br J Oral Maxillofac Surg 36:425–428
Whitlock EL, Tuffaha SH, Luciano JP et al (2009) Processed allografts and type I collagen conduits for repair of peripheral nerve gaps. Muscle Nerve 39:787–799
Wolford LM, Rodrigues DB (2011) Autogenous grafts/allografts/conduits for bridging peripheral trigeminal nerve gaps. Atlas Oral Maxillofac Surg Clin North Am 19:91–107
Zhang F, Blain B, Beck J et al (2002) Autogenous venous graft with one-stage prepared Schwann cells as a conduit for repair of long segmental nerve defects. J Reconstr Microsurg 18:295–300
Ziccardi VB, Steinberg MJ (2005) Timing of trigeminal nerve microsurgery: a review of the literature. J Oral Maxillofac Surg 65:1341–1345
Ziccardi VB (2011) Microsurgical techniques for repair of the inferior alveolar lingual nerves. Atlas Oral Maxillofac Surg Clin North Am 19:79–90
Zuniga JR, Chen N, Phillips CL (1997) Chemosensory and somatosensory regeneration after lingual nerve repair in humans. J Oral Maxillofac Surg 55:2–13
Zuniga JR (2001) Surgical management of trigeminal neuropathic pain. Atlas Oral Maxillofac Surg Clin North Am 9:59–75
Zuniga JR, Zenn MR (2001) Principles of microsurgery. Oral Maxillofac Clin North Am 13:331–342
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Interessenkonflikt. C.P. Cornelius gibt an, dass kein Interessenkonflikt besteht. Das vorliegende Manuskript enthält keine Studien an Menschen oder Tieren.
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Cornelius, C. Reparatur- und Rekonstruktionsverfahren der Nn. lingualis und alveolaris inferior. MKG-Chirurg 6, 184–204 (2013). https://doi.org/10.1007/s12285-012-0334-7
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DOI: https://doi.org/10.1007/s12285-012-0334-7
Schlüsselwörter
- Sensible mandibuläre Trigeminusäste
- Mikroneurale Interventionen
- Funktionelle Restitution und kritische Zeitgrenzen
- Erfolgsaussichten
- OP-Indikationsstellung