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Multilayered regulations of RIG-I in the anti-viral signaling pathway

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Abstract

RIG-I is a cytosolic receptor recognizing virus-specific RNA structures and initiates an antiviral signaling that induces the production of interferons and proinflammatory cytokines. Because inappropriate RIG-I signaling affects either viral clearance or immune toxicity, multiple regulations of RIG-I have been investigated since its discovery as the viral RNA detector. In this review, we describe the recent progress in research on the regulation of RIG-I activity or abundance. Specifically, we focus on the mechanism that modulates RIG-I-dependent antiviral response through post-translational modifications of or protein-protein interactions with RIG-I.

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Authors and Affiliations

  1. Department of Life Sciences, Pohang University of Science and Technology, Pohang, 37673, Republic of Korea

    Nari Kim, Hesung Now, Nhung T. H. Nguyen & Joo-Yeon Yoo

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  1. Nari Kim
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  2. Hesung Now
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  3. Nhung T. H. Nguyen
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Correspondence to Nari Kim or Joo-Yeon Yoo.

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Kim, N., Now, H., Nguyen, N.T.H. et al. Multilayered regulations of RIG-I in the anti-viral signaling pathway. J Microbiol. 54, 583–587 (2016). https://doi.org/10.1007/s12275-016-6322-2

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  • DOI: https://doi.org/10.1007/s12275-016-6322-2

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