Nano Research

, Volume 4, Issue 4, pp 405–413

In Vivo toxicity assessment of gold nanoparticles in Drosophila melanogaster

Authors

    • Italian Institute of TechnologyCenter for Bio-Molecular Nanotechnology
  • Giuseppe Vecchio
    • Italian Institute of TechnologyCenter for Bio-Molecular Nanotechnology
  • Antonio Galeone
    • Italian Institute of TechnologyCenter for Bio-Molecular Nanotechnology
  • Virgilio Brunetti
    • Italian Institute of TechnologyCenter for Bio-Molecular Nanotechnology
  • Stefania Sabella
    • Italian Institute of TechnologyCenter for Bio-Molecular Nanotechnology
  • Gabriele Maiorano
    • Italian Institute of TechnologyCenter for Bio-Molecular Nanotechnology
  • Andrea Falqui
    • Italian Institute of TechnologyCentral Research Laboratories
  • Giovanni Bertoni
    • Italian Institute of TechnologyCentral Research Laboratories
  • Roberto Cingolani
    • Italian Institute of TechnologyCenter for Bio-Molecular Nanotechnology
    • Italian Institute of TechnologyCentral Research Laboratories
Research Article

DOI: 10.1007/s12274-011-0095-z

Cite this article as:
Pompa, P.P., Vecchio, G., Galeone, A. et al. Nano Res. (2011) 4: 405. doi:10.1007/s12274-011-0095-z

Abstract

The growing use of nanomaterials in commercial goods and novel technologies is generating increasing questions about possible risks for human health and environment, due to the lack of an in-depth assessment of their potential toxicity. In this context, we investigated the effects of citrate-capped gold nanoparticles (AuNPs) on the model system Drosophila melanogaster upon ingestion. We observed a significant in vivo toxicity of AuNPs, which elicited clear adverse effects in treated organisms, such as a strong reduction of their life span and fertility, presence of DNA fragmentation, as well as a significant overexpression of the stress proteins. Transmission electron microscopy demonstrated the localization of the nanoparticles in tissues of Drosophila. The experimental evidence of high in vivo toxicity of a nanoscale material, which is widely considered to be safe and biocompatible in its bulk form, opens up important questions in many fields, including nanomedicine, material science, health, drug delivery and risk assessment.
https://static-content.springer.com/image/art%3A10.1007%2Fs12274-011-0095-z/MediaObjects/12274_2011_95_Fig1_HTML.jpg

Keywords

Nanoparticlesnanotoxicologygoldin vivo studies

Supplementary material

12274_2011_95_MOESM1_ESM.pdf (1003 kb)
Supplementary material, approximately 590 KB.

Copyright information

© Tsinghua University Press and Springer-Verlag Berlin Heidelberg 2011