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Chemical constituents from the fruiting bodies of Cryptoporus volvatus

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Abstract

New drimane-type sesquiterpene cryptoporol A (1), cryptoporic acid derivative 6′-cryptoporic acid E methyl ester (2), and pseudouridine derivative cryptoporine A (3), as well as a known ergosterol 5α,8α-epidioxy-22E-ergosta-6,22-dien-3β-ol (4), were isolated from a 90 % alcohol extract of the fruiting bodies of Cryptoporus volvatus. The structures of these compounds were established by spectroscopic analysis and circular dichroism. 5α,8α-epidioxy-22E-ergosta-6,22-dien-3β-ol (4) exhibited antiviral activity against porcine reproductive and respiratory syndrome virus, and all compounds showed weak antioxidant activities.

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Acknowledgments

This work was financially supported by the National Mega-Project for Innovative Drugs (2012ZX09301-002-001; 2011ZX09307-002-01), Young Scientist Funding from Beijing Natural Science Foundation (No. 7154225), and the program for Innovative Research Team in IMPLAD.

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Authors and Affiliations

  1. Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, 100193, People’s Republic of China

    Junchi Wang, Guangzhi Li, Na Lv, Li Gao, Li Cao, Liangang Shen & Jianyong Si

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  1. Junchi Wang
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  2. Guangzhi Li
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  3. Na Lv
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  4. Li Gao
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  5. Li Cao
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  7. Jianyong Si
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Correspondence to Jianyong Si.

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Wang, J., Li, G., Lv, N. et al. Chemical constituents from the fruiting bodies of Cryptoporus volvatus . Arch. Pharm. Res. 39, 747–754 (2016). https://doi.org/10.1007/s12272-016-0754-4

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