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CRISPR in der biotechnologischen Forschung und Entwicklung

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  • Genomeditierung
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Abstract

The discovery of programmable double-stranded DNA specific nucleases derived from the prokaryotic immunity systems CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) has opened a new era of genome editing and its applications in industrial biotechnology. Simple reprogramming of the DNA-specificity of CRISPR nucleases by RNAs allows the engineering of novel eukaryotic screening or producer cells through gene knock-out, chromosomal deletion and the regulation of gene expression.

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Authors and Affiliations

  1. B.R.A.I.N Aktiengesellschaft, BioActives & Performance Biologicals, Darmstädter Straße 34-36, D-64673, Zwingenberg, Deutschland

    Ümit Pul, Jörg Mampel, Christian Zurek & Michael Krohn

Authors
  1. Ümit Pul
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  2. Jörg Mampel
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  3. Christian Zurek
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  4. Michael Krohn
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Correspondence to Ümit Pul.

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Pul, Ü., Mampel, J., Zurek, C. et al. CRISPR in der biotechnologischen Forschung und Entwicklung. Biospektrum 22, 62–64 (2016). https://doi.org/10.1007/s12268-016-0659-2

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  • DOI: https://doi.org/10.1007/s12268-016-0659-2

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