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Eisen-Schwefel-Protein-Biogenese: Was Mitochondrien essenziell macht

Schwerpunkt Mitochondrien

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Abstract

Mitochondria are essential for the biosynthesis of Fe/S clusters (ISC) which serve as protein cofactors in enzyme catalysis, electron transfer and sensing. The mitochondrial ISC assembly machinery consists of 17 proteins which assist maturation of both organellar and cytosolic-nuclear Fe/S proteins. Some of the latter Fe/S proteins are indispensable for protein translation and nuclear DNA synthesis and repair. Thus, mitochondria perform a critical role in central processes of gene expression.

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Authors and Affiliations

  1. Institut für Zytobiologie und Synmikro Zentrum, Universität Marburg, Max-Planck-Institut für Terrestrische Mikrobiologie, Marburg, Germany

    Roland Lill

  2. Institut für Zytobiologie, Philipps-Universität Marburg, Robert-Koch-Straße 6, D-35032, Marburg, Germany

    Roland Lill

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  1. Roland Lill
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Correspondence to Roland Lill.

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Roland Lill Chemiestudium an den Universitäten Ulm und München. 1986 Promotion an der LMU München. 1987–1989 Postdoktorand als DFG-Stipendiat, University of California, Los Angeles, USA. 1990–1996 Gruppenleiter, Institut für Physiologische Chemie der LMU München. 1996 Habilitation. Seit 1996 Professor für Zellbiologie am Fachbereich Medizin der Universität Marburg.

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Lill, R. Eisen-Schwefel-Protein-Biogenese: Was Mitochondrien essenziell macht. Biospektrum 19, 128–130 (2013). https://doi.org/10.1007/s12268-013-0279-z

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